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http://dx.doi.org/10.3345/kjp.2018.06849

Transfusion practice in neonates  

Kim, Do-Hyun (Department of Pediatrics, Dongguk University Ilsan Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.61, no.9, 2018 , pp. 265-270 More about this Journal
Abstract
Neonates, especially extremely low birth weight infants, are among the groups of patients undergoing transfusion frequently. Since they are exposed to higher specific transfusion risks compared to the patients of other age groups, there are many special aspects that must be considered for transfusion therapy in neonates. The transfusion risks in neonates include adverse outcomes specific for preterm infants as well as increased metabolic, immunologic, and infectious complications. To reduce the risks of transfusion-transmitted cytomegalovirus infection and transfusion-associated graft-versus-host disease, leukoreduced and irradiated cellular blood products should be used for all neonates. This review summarizes the risks of neonatal transfusion therapy, specific methods to reduce risk, and current trends and practices of red blood cell and platelet transfusions in neonates, to facilitate decision-making for neonatal transfusion.
Keywords
Neonates; Transfusion; Red blood cell; Platelet;
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1 Valieva OA, Strandjord TP, Mayock DE, Juul SE. Effects of transfusions in extremely low birth weight infants: a retrospective study. J Pediatr 2009;155:331-37.e1.   DOI
2 Zhang Z, Huang X, Lu H. Association between red blood cell transfusion and bronchopulmonary dysplasia in preterm infants. Sci Rep 2014;4:4340.
3 Korhonen P, Tammela O, Koivisto AM, Laippala P, Ikonen S. Frequency and risk factors in bronchopulmonary dysplasia in a cohort of very low birth weight infants. Early Hum Dev 1999;54:245-58.   DOI
4 Mally P, Golombek SG, Mishra R, Nigam S, Mohandas K, Depalhma H, et al. Association of necrotizing enterocolitis with elective packed red blood cell transfusions in stable, growing, premature neonates. Am J Perinatol 2006;23:451-8.   DOI
5 Josephson CD, Wesolowski A, Bao G, Sola-Visner MC, Dudell G, Castillejo MI, et al. Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? J Pediatr 2010;157:972-8.e1-3.   DOI
6 Blau J, Calo JM, Dozor D, Sutton M, Alpan G, La Gamma EF. Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion. J Pediatr 2011;158:403-9.   DOI
7 Marin T, Moore J, Kosmetatos N, Roback JD, Weiss P, Higgins M, et al. Red blood cell transfusion-related necrotizing enterocolitis in verylow-birthweight infants: a near-infrared spectroscopy investigation. Transfusion 2013;53:2650-8.   DOI
8 Baer VL, Lambert DK, Henry E, Snow GL, Christensen RD. Red blood cell transfusion of preterm neonates with a Grade 1 intraventricular hemorrhage is associated with extension to a Grade 3 or 4 hemorrhage. Transfusion 2011;51:1933-9.   DOI
9 Christensen RD, Baer VL, Lambert DK, Ilstrup SJ, Eggert LD, Henry E. Association, among very-low-birthweight neonates, between red blood cell transfusions in the week after birth and severe intraventricular hemorrhage. Transfusion 2014;54:104-8.   DOI
10 Inder TE, Clemett RS, Austin NC, Graham P, Darlow BA. High iron status in very low birth weight infants is associated with an increased risk of retinopathy of prematurity. J Pediatr 1997;131:541-4.   DOI
11 Dani C, Reali MF, Bertini G, Martelli E, Pezzati M, Rubaltelli FF. The role of blood transfusions and iron intake on retinopathy of prematurity. Early Hum Dev 2001;62:57-63.   DOI
12 Galal SA. Therapeutic techniques. Selection of blood components for neonatal transfusion. NeoReviews 2005;6:c351-5.   DOI
13 Dos Santos AM, Trindade CE. Red blood cell transfusions on the neonate. NeoReviews 2011;12:c13-9.   DOI
14 Bell EF, Strauss RG, Widness JA, Mahoney LT, Mock DM, Seward VJ, et al. Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 2005;115:1685-91.   DOI
15 El-Dib M, Narang S, Lee E, Massaro AN, Aly H. Red blood cell transfusion, feeding and necrotizing enterocolitis in preterm infants. J Perinatol 2011;31:183-7.   DOI
16 Christensen RD. Associations between "early" red blood cell transfusion and severe intraventricular hemorrhage, and between "late" red blood cell transfusion and necrotizing enterocolitis. Semin Perinatol 2012;36:283-9.   DOI
17 Fergusson D, Hebert PC, Lee SK, Walker CR, Barrington KJ, Joseph L, et al. Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants. JAMA 2003;289:1950-6.   DOI
18 Korea Centers for Disease Control and Prevention. Korean society of blood transfusion. Transfusion Guideline. 4th ed. Cheongju (Korea):Korea Centers for Disease Control and Prevention, 2016.
19 Spinella PC, Dressler A, Tucci M, Carroll CL, Rosen RS, Hume H, et al. Survey of transfusion policies at US and Canadian children's hospitals in 2008 and 2009. Transfusion 2010;50:2328-35.   DOI
20 Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA, et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006;149:301-7.   DOI
21 Whyte RK, Kirpalani H, Asztalos EV, Andersen C, Blajchman M, Heddle N, et al. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics 2009;123:207-13.   DOI
22 Whyte R, Kirpalani H. Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev 2011;(11):CD000512.
23 Ekhaguere OA, Morriss FH Jr, Bell EF, Prakash N, Widness JA. Predictive factors and practice trends in red blood cell transfusions for very-low-birth-weight infants. Pediatr Res 2016;79:736-41.   DOI
24 Murray NA, Howarth LJ, McCloy MP, Letsky EA, Roberts IA. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med 2002;12:35-41.   DOI
25 Korean Society of Neonatology. Manual of neonatal care. 3rd ed. Seoul (Korea): Korean Society of Neonatology, 2014:303.
26 Hensch LA, Indrikovs AJ, Shattuck KE. Transfusion in extremely lowbirth-weight premature neonates: current practices trends, risks, and early interventions to decrease the need for transfusion. NeoReviews 2015;16:c287-96.   DOI
27 Fergusson DA, Hebert P, Hogan DL, LeBel L, Rouvinez-Bouali N, Smyth JA, et al. Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial. JAMA 2012;308:1443-51.   DOI
28 Muthukumar P, Venkatesh V, Curley A, Kahan BC, Choo L, Ballard S, et al. Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions. Transfus Med 2012;22:338-43.   DOI
29 Borges JP, dos Santos AM, da Cunha DH, Mimica AF, Guinsburg R, Kopelman BI. Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants. Vox Sang 2013;104:207-13.   DOI
30 Korean Society of Neonatology. Manual of neonatal care. 3rd ed. Seoul (Korea): Korean Society of Neonatology, 2014:315.
31 Delaney M, Mayock D, Knezevic A, Norby-Slycord C, Kleine E, Patel R, et al. Postnatal cytomegalovirus infection: a pilot comparative effectiveness study of transfusion safety using leukoreduced-only transfusion strategy. Transfusion 2016;56:1945-50.   DOI
32 Cooke RW, Drury JA, Yoxall CW, James C. Blood transfusion and chronic lung disease in preterm infants. Eur J Pediatr 1997;156:47-50.
33 Maier RF, Sonntag J, Walka MM, Liu G, Metze BC, Obladen M. Changing practices of red blood cell transfusions in infants with birth weights less than 1000 g. J Pediatr 2000;136:220-4.   DOI
34 Fasano RM, Said M, Luban NL. Blood component therapy for the neonate. In: Martin RJ, Fanaroff AV, Walsh MC, editors. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. 10th ed. Philadelphia (PA): Elsevier Saunders, 2015:1344-61.
35 Goodstein MH, Locke RG, Wlodarczyk D, Goldsmith LS, Rubenstein SD, Herman JH. Comparison of two preservation solutions for erythrocyte transfusions in newborn infants. J Pediatr 1993;123:783-8.   DOI
36 U.S. Food and Drug Administration. Fatalities reported to FDA following blood collection and transfusion: annual summary for fiscal year 2012 [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; [cited 2018 May 15]. Available from: http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/ReportaProblem/TransfusionDonationFatalities/ucm346639.htm.
37 Ohto H, Anderson KC. Posttransfusion graft-versus-host disease in Japanese newborns. Transfusion 1996;36:117-23.   DOI
38 Linden JV, Pisciotto PT. Transfusion-associated graft-versus-host disease and blood irradiation. Transfus Med Rev 1992;6:116-23.   DOI
39 Fasano R, Luban NL. Blood component therapy. Pediatr Clin North Am 2008;55:421-45, ix.   DOI
40 Josephson CD, Caliendo AM, Easley KA, Knezevic A, Shenvi N, Hinkes MT, et al. Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study. JAMA Pediatr 2014;168:1054-62.   DOI
41 Strauss RG. Optimal prevention of transfusion-transmitted cytomegalovirus (TTCMV) infection by modern leukocyte reduction alone: CMV sero/antibody-negative donors needed only for leukocyte products. Transfusion 2016;56:1921-4.   DOI
42 Patel RM, Josephson CD. Neonatal transfusion. In: Gleason CA, Juul SE, editors. Avery's of the newborn. 10th ed. Philadelphia (PA): Elsevier Saunders, 2018:1180-6.