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http://dx.doi.org/10.3345/kjp.2018.07199

Scabies mimicking graft versus host disease in a hematopoietic cell transplant recipient  

Kim, Dongsub (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Choi, Soo-Han (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine)
Lee, Dong Youn (Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Juyoun (Department of Pediatrics, Samsung Medical Center)
Cho, Eunjoo (Department of Pediatrics, Samsung Medical Center)
Yoo, Keon Hee (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Koo, Hong Hoe (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Yae-Jean (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.61, no.11, 2018 , pp. 371-373 More about this Journal
Abstract
Scabies is a highly contagious skin infestation caused by the mite, Sarcoptes scabiei var. hominis. Complex responses to scabies mites in the innate, humoral, and cellular immune systems can cause skin inflammation and pruritus. Diagnosis can be challenging because scabies resembles other common skin conditions. We report the first Korean case of scabies in a hematopoietic cell transplant (HCT) recipient, initially suspected of skin graft versus host disease (GVHD). A T-cell acute lymphocytic leukemia patient underwent a sibling-matched allogeneic HCT and developed pruritus after cell engraftment. Treatment for GVHD did not improve the symptoms. He was diagnosed with scabies 30 days after the onset of symptoms.
Keywords
Scabies; Graft versus host disease; Hematopoietic cell transplant;
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1 Park H, Lee C, Park S, Kwon H, Kweon SS. Scabies among elderly Korean patients with histories of leprosy. Am J Trop Med Hyg 2016;95:75-6.   DOI
2 Ahn YS, Lim HS. Occupational infectious diseases among Korean health care workers compensated with Industrial Accident Compensation Insurance from 1998 to 2004. Ind Health 2008;46:448-54.   DOI
3 Smith DR, Choi JW, Yu DS, Ki M, Oh CH, Yamagata Z. Skin disease among staff in a large Korean nursing home. Tohoku J Exp Med 2002;198:175-80.   DOI
4 Peterson CM, Eichenfield LF. Scabies. Pediatr Ann 1996;25:97-100.   DOI
5 Wang CX, Anadkat MJ, Musiek AC. Dermatologic conditions of the early post-transplant period in hematopoietic stem cell transplant recipients. Am J Clin Dermatol 2018 Oct 8 [Epub]. https://doi.org/10.1007/s40257-018-0391-4.
6 Walton SF, Beroukas D, Roberts-Thomson P, Currie BJ. New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. Br J Dermatol 2008;158:1247-55.   DOI
7 Bhat SA, Mounsey KE, Liu X, Walton SF. Host immune responses to the itch mite, Sarcoptes scabiei, in humans. Parasit Vectors 2017;10:385.   DOI
8 Roberts LJ, Huffam SE, Walton SF, Currie BJ. Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J Infect 2005;50:375-81.   DOI
9 Barnes L, McCallister RE, Lucky AW. Crusted (Norwegian) scabies. Occurrence in a child undergoing a bone marrow transplant. Arch Dermatol 1987;123:95-7.   DOI
10 Vyas P, Kinsey SE, Goldstone AH. Scabies infestation following autologous bone marrow transplantation. Leuk Lymphoma 1990;3:73-4.   DOI
11 Cheng VC, Yuen KY, Wong SS, Woo PC, Ho PL, Lee R, et al. Immunorestitution diseases in patients not infected with HIV. Eur J Clin Microbiol Infect Dis 2001;20:402-6.
12 Ortega-Loayza AG, McCall CO, Nunley JR. Crusted scabies and multiple dosages of ivermectin. J Drugs Dermatol 2013;12:584-5.
13 Romani L, Whitfeld MJ, Koroivueta J, Kama M, Wand H, Tikoduadua L, et al. Mass drug administration for scabies control in a population with endemic disease. N Engl J Med 2015;373:2305-13.   DOI
14 Chosidow O. Clinical practices. Scabies. N Engl J Med 2006;354:1718-27.   DOI