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http://dx.doi.org/10.3345/kjp.2016.59.4.183

Correlation of B-type natriuretic peptide levels and echocardiographic parameters in preterm infants with patent ductus arteriosus  

Jeong, Hyun Ah (Department of Pediatrics, Korea University College of Medicine)
Shin, Jeonghee (Department of Pediatrics, Korea University College of Medicine)
Kim, Eunji (Department of Pediatrics, Korea University College of Medicine)
Lee, Eun Hee (Department of Pediatrics, Korea University College of Medicine)
Choi, Byung Min (Department of Pediatrics, Korea University College of Medicine)
Son, Chang Sung (Department of Pediatrics, Korea University College of Medicine)
Lee, Joo Won (Department of Pediatrics, Korea University College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.59, no.4, 2016 , pp. 183-189 More about this Journal
Abstract
Purpose: This study aimed to evaluate the correlation, according to postnatal age, between plasma B-type natriuretic peptide (BNP) levels and echocardiographic parameters for the assessment of patent ductus arteriosus (PDA) in preterm infants with respiratory distress. Methods: We enrolled 42 preterm infants with respiratory distress who underwent serial echocardiographic evaluation with simultaneous plasma BNP measurements until ductal closure. The correlations between BNP levels and the following 4 representative echocardiographic parameters were studied: diameter of the ductus arteriosus (DA), ratio of the left atrial diameter to the aortic diameter (LA/Ao), ratio of the PDA diameter to the infant's left pulmonary artery diameter (PDA/LPA), and the antegrade diastolic flow of LPA (DFLPA). Results: BNP levels were significantly correlated to the magnitude of the ductal shunt, comprising the DA diameter, PDA/LPA ratio, LA/Ao ratio, and antegrade DFLPA for the overall study period. The earliest significant correlation, starting from postnatal day 2, was observed between the LA/Ao ratio and BNP levels. The PDA/LPA ratio and the antegrade DFLPA showed significant correlations with BNP levels postnatal day 3 onward, and with the DA diameter, postnatal day 5 onward. Conclusion: BNP levels and echocardiographic parameters showed a positive correlation, but the significance of the correlations differed according to the postnatal age, especially during the first few days of life.
Keywords
Patent ductus arteriosus; B-type natriuretic peptide; Echocardiography; Premature infant;
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Times Cited By KSCI : 1  (Citation Analysis)
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