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http://dx.doi.org/10.3345/kjp.2011.54.9.385

Candida tropicalis arthritis of the elbow in a patient with Ewing's sarcoma that successfully responded to itraconazole  

Kim, Seung-Youn (Department of Pediatrics, Korean Cancer Center Hospital)
Lim, Jung-Sub (Department of Pediatrics, Korean Cancer Center Hospital)
Kim, Dong-Hwan (Department of Pediatrics, Korean Cancer Center Hospital)
Lee, Hyeon-Jeong (Department of Pediatrics, Korean Cancer Center Hospital)
Cho, Joong-Bum (Department of Pediatrics, Korean Cancer Center Hospital)
Lee, Jun-Ah (Department of Pediatrics, Korean Cancer Center Hospital)
Kim, Dong-Ho (Department of Pediatrics, Korean Cancer Center Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.54, no.9, 2011 , pp. 385-388 More about this Journal
Abstract
Fungal infections are rarely responsible for arthritis. Few cases of fungal arthritis have been reported, even in immunocompromised hosts susceptible to low-virulence organisms. Herein, the authors report the first case of Candida tropicalis arthritis in a child with a solid tumor. A 13-year-old boy with Ewing's sarcoma developed arthritis in his elbow during the neutropenic period after chemotherapy. Despite treatment with broad-spectrum antibiotics, his condition did not improve and serial blood cultures failed to reveal any causative organisms. After surgical drainage, culture of the joint fluid revealed the presence of C. tropicalis. Itraconazole treatment was started and after 3 months of therapy, the patient completely recovered full elbow function.
Keywords
Candida tropicalis; Arthritis; Sarcoma; Itraconazole; Neutropenia; Child;
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