Browse > Article
http://dx.doi.org/10.3345/kjp.2010.53.8.779

Multimodal neuroimaging in presurgical evaluation of childhood epilepsy  

Jung, Da-Eun (Department of Pediatrics, Ajou University School of Medicine)
Lee, Joon-Soo (Department of Pediatrics, Pediatric Epilepsy Clinic, Severance Children's Hospital, Brain Research Institute, Yonsei University College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.53, no.8, 2010 , pp. 779-785 More about this Journal
Abstract
In pre-surgical evaluation of pediatric epilepsy, the combined use of multiple imaging modalities for precise localization of the epileptogenic focus is a worthwhile endeavor. Advanced neuroimaging by high field Magnetic resonance imaging (MRI), diffusion tensor images, and MR spectroscopy have the potential to identify subtle lesions. $^{18}F$-FDG positron emission tomography and single photon emission tomography provide visualization of metabolic alterations of the brain in the ictal and interictal states. These techniques may have localizing value for patients which exhibit normal MRI scans. Functional MRI is helpful for non-invasively identifying areas of eloquent cortex. These advances are improving our ability to noninvasively detect epileptogenic foci which have gone undetected in the past and whose accurate localization is crucial for a favorable outcome following surgical resection.
Keywords
Multimodal neuroimaging; Childhood epilepsy; Surgery;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Okumura A, Fukatsu H, Kato K, Ikuta T, Watanabe K. Diffusion tensor imaging in frontal lobe epilepsy. Pediatr Neurol 2004;31:203-6.   DOI   ScienceOn
2 Gaillard WD. Functional MR imaging of language, memory, and sensorimotor cortex. Neuroimaging Clin N Am 2004;14:471-85.   DOI   ScienceOn
3 Lee SK, Lee SY, Yun CH, Lee HY, Lee JS, Lee DS. Ictal SPECT in neocortical epilepsies: clinical usefulness and factors affecting the pattern of hyperperfusion. Neuroradiology 2006;48:678-84.   DOI   ScienceOn
4 Aasly J, Silfvenius H, Aas TC, Sonnewald U, Olivecrona M, Juul R, et al. Proton magnetic resonance spectroscopy of brain biopsies from patients with intractable epilepsy. Epilepsy Res 1999;35:211-7.   DOI   ScienceOn
5 Sundgren PC, Dong Q, Gomez-Hassan D, Mukherji SK, Maly P, Welsh R. Diffusion tensor imaging of the brain: review of clinical applications. Neuroradiology 2004;46:339-50.   DOI   ScienceOn
6 Wehner T, Luders H. Role of Neuroimaging in the presurgical evaluation of epilepsy. J Clin Neurol 2008;4 1-16.   DOI   ScienceOn
7 Knake S, Triantafyllou C, Wald LL, Wiggins G, Kirk GP, Larsson PG, et al. 3T phased array MRI improves the presurgical evaluation in focal epilepsies: a prospective study. Neurology 2005;65:1026-31.   DOI   ScienceOn
8 Henry TR, Babb TL, Engel J, Jr, Mazziotta JC, Phelps ME, Crandall PH. Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy. Ann Neurol 1994;36:925-7.   DOI   ScienceOn
9 Cornford EM, Gee MN, Swartz BE, Mandelkern MA, Blahd WH, Landaw EM, et al. Dynamic [18F]fluorodeoxyglucose positron emission tomography and hypometabolic zones in seizures: reduced capillary influx. Ann Neurol 1998;43:801-8.   DOI   ScienceOn
10 Choi JY, Kim SJ, Hong SB, Seo DW, Hong SC, Kim BT, et al. Extratemporal hypometabolism on FDG PET in temporal lobe epilepsy as a predictor of seizure outcome after temporal lobectomy. Eur J Nucl Med Mol Imaging 2003;30:581-7.   DOI   ScienceOn
11 Kim JT, Bai SJ, Choi KO, Lee YJ, Park HJ, Kim DS, et al. Comparison of various imaging modalities in localization of epileptogenic lesion using epilepsy surgery outcome in pediatric patients. Seizure 2009;18:504-10.   DOI   ScienceOn
12 Kuzniecky R, Palmer C, Hugg J, Martin R, Sawrie S, Morawetz R, et al. Magnetic resonance spectroscopic imaging in temporal lobe epilepsy: neuronal dysfunction or cell loss? Arch Neurol 2001;58:2048-53.   DOI   ScienceOn
13 Kuzniecky R, Hugg J, Hetherington H, Martin R, Faught E, Morawetz R, et al. Predictive value of 1H MRSI for outcome in temporal lobectomy. Neurology 1999;53:694-8.   DOI
14 Goffin K, Dedeurwaerdere S, Van Laere K, Van Paesschen W. Neuronuclear assessment of patients with epilepsy. Semin Nucl Med 2008;38:227-39.   DOI   ScienceOn
15 Van Paesschen W. Ictal SPECT. Epilepsia 2004;45 Suppl 4:35-40.
16 O'Brien TJ, So EL, Mullan BP, Hauser MF, Brinkmann BH, Bohnen NI, et al. Subtraction ictal SPECT co-registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus. Neurology 1998;50:445-54.   DOI   ScienceOn
17 Hammers A, Koepp MJ, Richardson MP, Hurlemann R, Brooks DJ, Duncan JS. Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients. Brain 2003;126:1300-18.   DOI   ScienceOn
18 Vinton AB, Carne R, Hicks RJ, Desmond PM, Kilpatrick C, Kaye AH, et al. The extent of resection of FDG-PET hypometabolism relates to outcome of temporal lobectomy. Brain 2007;130:548-60.   DOI   ScienceOn
19 Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Mangner TJ, et al. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 2003;60:960-8.   DOI   ScienceOn
20 Kagawa K, Chugani DC, Asano E, Juhasz C, Muzik O, Shah A, et al. Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]Methyl-L-Tryptophan positron emission tomography (PET). J Child Neurol 2005;20:429-38.   DOI   ScienceOn
21 Yun CH, Lee SK, Lee SY, Kim KK, Jeong SW, Chung CK. Prognostic factors in neocortical epilepsy surgery: multivariate analysis. Epilepsia 2006;47:574-9.   DOI   ScienceOn
22 Muzik O, Chugani DC, Shen C, de Silva EA, Shah J, Shah A, et al. Objective method for localization of cortical asymmetries using positron emission tomography to aid surgical resection of epileptic foci. Comput Aided Surg 1998;3:74-82.   DOI   ScienceOn
23 Won HJ, Chang KH, Cheon JE, Kim HD, Lee DS, Han MH, et al. Comparison of MR imaging with PET and ictal SPECT in 118 patients with intractable epilepsy. AJNR Am J Neuroradiol 1999;20:593-9.
24 Muzik O, de Silva EA, Juhasz C, Chugani DC, Shah J, Nagy F, et al. Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology 2000;54:171-9.   DOI   ScienceOn
25 Zijlmans M, de Kort GA, Witkamp TD, Huiskamp GM, Seppenwoolde JH, van Huffelen AC, et al. 3T versus 1.5T phased-array MRI in the presurgical work-up of patients with partial epilepsy of uncertain focus. J Magn Reson Imaging 2009;30:256-62.   DOI   ScienceOn
26 Foldvary N, Lee N, Hanson MW, Coleman RE, Hulette CM, Friedman AH, et al. Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy. Epilepsia 1999;40:26-9.   DOI   ScienceOn
27 Ruggieri PM, Najn IM. MR imaging in epilepsy. Neurol Clin 2001;19:477-89.   DOI   ScienceOn
28 Salamon N, Kung J, Shaw SJ, Koo J, Koh S, Wu JY, et al. FDG-PET/ MRI coregistration improves detection of cortical dysplasia in patients with epilepsy. Neurology 2008;71:1594-601.   DOI   ScienceOn
29 Barkovich AJ, Kuzniecky RI. Neuroimaging of focal malformations of cortical development. J Clin Neurophysiol 1996;13:481-94.   DOI   ScienceOn
30 Widdess-Walsh P, Diehl B, Najm I. Neuroimaging of focal cortical dysplasia. J Neuroimaging 2006;16:185-96.   DOI   ScienceOn
31 Lori NF, Akbudak E, Shimony JS, Cull TS, Snyder AZ, Guillory RK, et al. Diffusion tensor fiber tracking of human brain connectivity: aquisition methods, reliability analysis and biological results. NMR Biomed 2002;15:494-515.   DOI   ScienceOn
32 De Coene B, Hajnal JV, Gatehouse P, Longmore DB, White SJ, Oatridge A, et al. MR of the brain using fluid-attenuated inversion recovery (FLAIR) pulse sequences. AJNR Am J Neuroradiol 1992;13:1555-64.
33 Wyllie E, Comair YG, Kotagal P, Bulacio J, Bingaman W, Ruggieri P. Seizure outcome after epilepsy surgery in children and adolescents. Ann Neurol 1998;44:740-8.   DOI   ScienceOn
34 Li LM, Fish DR, Sisodiya SM, Shorvon SD, Alsanjari N, Stevens JM. High resolution magnetic resonance imaging in adults with partial or secondary generalised epilepsy attending a tertiary referral unit. J Neurol Neurosurg Psychiatry 1995;59:384-7.   DOI   ScienceOn
35 Rabin ML, Narayan VM, Kimberg DY, Casasanto DJ, Glosser G, Tracy JI, et al. Functional MRI predicts post-surgical memory following temporal lobectomy. Brain 2004;127:2286-98.   DOI   ScienceOn
36 Gaillard WD, Balsamo L, Xu B, Grandin CB, Braniecki SH, Papero PH, et al. Language dominance in partial epilepsy patients identified with an fMRI reading task. Neurology 2002;59:256-65.   DOI   ScienceOn
37 Yetkin FZ, Mueller WM, Morris GL, McAuliffe TL, Ulmer JL, Cox RW, et al. Functional MR activation correlated with intraoperative cortical mapping. AJNR Am J Neuroradiol 1997;18:1311-5.
38 Sabsevitz DS, Swanson SJ, Hammeke TA, Spanaki MV, Possing ET, Morris GL 3rd, et al. Use of preoperative functional neuroimaging to predict language deficits from epilepsy surgery. Neurology 2003;60:1788-92.   DOI   ScienceOn
39 Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S. Fiber tract-based atlas of human white matter anatomy. Radiology 2004;230:77-87.   DOI   ScienceOn
40 Lee SK, Kim DI, Mori S, Kim J, Kim HD, Heo K, et al. Diffusion tensor MRI visualizes decreased subcortical fiber connectivity in focal cortical dysplasia. Neuroimage 2004;22:1826-29.   DOI   ScienceOn
41 Jack CR Jr, Thompson RM, Butts RK, Sharbrough FW, Kelly PJ, Hanson DP, et al. Sensory motor cortex: correlation of presurgical mapping with functional MR imaging and invasive cortical mapping. Radiology 1994;190:85-92.
42 Rao SM, Binder JR, Bandettini PA, Hammeke TA, Yetkin FZ, Jesmanowicz A, et al. Functional magnetic resonance imaging of complex human movements. Neurology 1993;43:2311-8.   DOI   ScienceOn
43 Hammeke TA, Yetkin FZ, Mueller WM, Morris GL, Haughton VM, Rao SM, et al. Functional magnetic resonance imaging of somatosensory stimulation. Neurosurgery 1994;35:677-81.   DOI   ScienceOn
44 Arfanakis K, Hermann BP, Rogers BP, Carew JD, Seidenberg M, Meyerand ME. Diffusion tensor MRI in temporal lobe epilepsy. Magn Reson Imaging 2002;20:511-9.   DOI   ScienceOn
45 Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637-48.
46 Rugg-Gunn FJ, Eriksson SH, Symms MR, Barker GJ, Duncan JS. Diffusion tensor imaging of cryptogenic and acquired partial epilepsies. Brain 2001;124:627-36.   DOI   ScienceOn
47 Rugg-Gunn FJ, Eriksson SH, Symms MR, Barker GJ, Thom M, Harkness W, et al. Diffusion tensor imaging in refractory epilepsy. Lancet 2002;359:1748-51.   DOI   ScienceOn