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http://dx.doi.org/10.3345/kjp.2010.53.7.735

Renal fibrosis  

Cho, Min-Hyun (Department of Pediatrics, Kyungpook National University School of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.53, no.7, 2010 , pp. 735-740 More about this Journal
Abstract
Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease. Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components. This pathologic result usually originates from both underlying complicated cellular activities such as epithelial-to-mesenchymal transition, fibroblast activation, monocyte/macrophage infiltration, and cellular apoptosis and the activation of signaling molecules such as transforming growth factor beta and angiotensin II. However, because the pathogenesis of renal fibrosis is extremely complicated and our knowledge regarding this condition is still limited, further studies are needed.
Keywords
Fibrosis; Glomerulosclerosis; Kidney disease;
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