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http://dx.doi.org/10.3345/kjp.2010.53.2.152

Clinical characteristics of vitamin D deficiency rickets in infants and preschool children  

Huh, Kyoung (Department of Pediatrics, Inje University College of Medicine)
Woo, Mi Kyeong (Department of Pediatrics, Inje University College of Medicine)
Yoon, Jung Rim (Department of Pediatrics, Inje University College of Medicine)
Shim, Gyu Hong (Department of Pediatrics, Inje University College of Medicine)
Chey, Myoung Jae (Department of Pediatrics, Inje University College of Medicine)
Park, Mi Jung (Department of Pediatrics, Inje University College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.53, no.2, 2010 , pp. 152-157 More about this Journal
Abstract
Purpose : Vitamin D deficiency rickets is a significant public health problem that results from insufficient exposure to sunlight and inadequate vitamin D supplementation. The purpose of this study is to identify the clinical characteristics of vitamin D deficiency rickets in infants. Methods : Data of 35 infants diagnosed as vitamin D deficiency rickets at Sanggye-Paik Hospital, Seoul, Korea, from March 2007 to May 2009 were reviewed. Children with plasma 25-hydroxyvitamin D levels <15 ng/mL and 15-30 ng/mL were considered to have vitamin D deficiency and vitamin D insufficiency, respectively. Results : Thirty-five infants (22 boys, 13 girls) were diagnosed with rickets. Mean age at diagnosis was $7.4{\pm}7.1$ months (range: 0.1-29.8 months). Eighteen infants (51%) were vitamin D deficient and seventeen infants (49%) were insufficient. Twenty-eight of all (80%) diagnosed as subclinical rickets. Twenty-nine infants (83%) were below the age of 12months. Twenty infants (57%) had breastfed and ten infants (29%) had iron deficiency anemia. Nine of breastfed infants (45%) were vitamin D deficient and ten of their mothers were vitamin D insufficient. Overall, radiographic evidence of rickets was present in 93% of the cases. Radiographic sign of rickets was evident even in vitamin D insufficient state. Conclusion : It is important for the clinician to screen for subclinical vitamin D deficiency rickets in inadequately supplemented infants by pairing 25-hydroxyvitamin D levels with wrist radiographs. A nationwide epidemiological study of vitamin D deficiency rickets must be conducted and evidence-based national guidelines must be defined to prevent rickets.
Keywords
Vitamin D deficiency; Rickets; Infant;
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Times Cited By KSCI : 2  (Citation Analysis)
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