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http://dx.doi.org/10.3345/kjp.2009.52.6.713

Facial palsy as the presenting symptom of acute myeloid leukemia in children: Three cases with stem cell transplantations  

Baek, Hee Jo (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
Han, Dong Kyun (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
Kim, Young Ok (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
Choi, Ic Sun (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
Hwang, Tai Ju (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
Kook, Hoon (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.6, 2009 , pp. 713-716 More about this Journal
Abstract
Facial palsy as the presenting symptom of leukemia is very rare, especially in acute myeloid leukemia. A review of the medical literature identified reports on 8 children with AML who had facial paralysis as the presenting sign. Whole brain irradiation (WBI) has been applied in most cases. We present the cases of 3 such children. Achieving a remission without WBI, the patients underwent stem cell transplantations (SCTs). Two patients remain event-free 52 months and 62 months after allotransplants. Facial palsy was the harbinger of leukemic relapse in one case after autotransplant. This patient is disease-free 59 months after unrelated SCT rescue. Facial palsy persisted in 2 cases. Allogeneic SCT without WBI may be an effective therapy in patients presenting with facial palsy. A brief review of the literature is presented here.
Keywords
Facial palsy; Acute myeloid leukemia; Whole brain irradiation; Stem cell transplantation; Children;
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