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http://dx.doi.org/10.3345/kjp.2009.52.3.389

A case of antiepileptic drug hypersensitivity syndrome by lamotrigine mimicking infectious mononucleosis and atypical Kawasaki disease  

Yoo, Su Jung (Department of Pediatrics, Soonchunhyang University)
Park, Ihl Sung (Department of Pediatrics, Soonchunhyang University)
Suh, Eun Sook (Department of Pediatrics, Soonchunhyang University)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.3, 2009 , pp. 389-391 More about this Journal
Abstract
Antiepileptic drug hypersensitivity syndrome (AHS), a delayed immunological reaction, is a relatively rare side effect of antiepileptic drugs and is usually overlooked. An array of symptoms can occur one to eight weeks after treatment with an antiepileptic drug. Symptoms may be as simple as a fever, skin rash, or lymphadenopathy, but may eventually involve internal organs and cause fatal outcomes. Additionally, because the symptoms resemble the features of various arrays of diseases and the reported mortality rate is approximately 10%, the importance of early diagnosis and ability to differentiate AHS from other diseases cannot be overemphasized. We report a case of a 14-year-old girl with AHS caused by lamotrigine, which mimicked atypical Kawasaki disease and infectious mononucleosis.
Keywords
Lamotrigine; Antiepileptic hypersensitivity syndrome;
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