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http://dx.doi.org/10.3345/kjp.2009.52.1.99

Usefulness of DTI-based three dimensional corticospinal tractography in children with hemiplegic cerebral palsy  

Yeo, Ji Hyun (Department of Pediatrics, the Department of Physical Medicine College of Medicine, Yeungnam Univeristy)
Son, Su Min (Department of Pediatrics, the Department of Rehabilitation College of Medicine, Yeungnam Univeristy)
Lee, Eun Sil (Department of Pediatrics, the Department of Physical Medicine College of Medicine, Yeungnam Univeristy)
Moon, Han Ku (Department of Pediatrics, the Department of Physical Medicine College of Medicine, Yeungnam Univeristy)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.1, 2009 , pp. 99-104 More about this Journal
Abstract
Purpose : Magnetic resonance diffusion tensor imaging-based three-dimensional fiber tractography (DTI-FT) is a new method which demonstrates the orientation and integrity of white matter fibers in vivo. However, clinical application on children with cerebral palsy is still under investigation. We present various abnormal patterns of DTI-FT findings and accordance rate with clinical findings in children with hemiplegic cerebral palsy, to recognize the use fulness of DTI-FT. Methods : The thirteen children with hemiplegic cerebral palsy evaluated at Yeungnam University hospital from March, 2003 to August, 2007 were enrolled in this study and underwent magnetic resonance DTI-FT of the corticospinal tracts. Two regions of interest (ROI) were applied and the termination criteria were fractional anisotropy ${\geq}0.3$, angle ${\leq}70^{\circ}$. Results : The patterns and distribution of abnormal DTI-based corticospinal tractographic findings were interruption(10 cases, 76.9%), reduction of fiber volume (8 cases, 61.5%), agenesis of corticospinal tract (3 cases, 23.1%), transcallosal fiber (2 cases, 15.4%) and, aberrant corticospinal tracts (4 cases, 30.8%). Abnormal DTI-based corticospinal tractographic findings were in accordance with the clinical findings of cerebral palsy in 84.6% of the enrolled patients. Conclusion : Our results suggest that DTI-FT would be a use ful modality in the assessment of the corticospinal tract abnormalities in children with hemiplegic cerebral palsy.
Keywords
Cerebral palsy; Diffusion tensor MR imaging; Fiber tractography; Corticospinal tract;
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1 Bax M, Goldstein M, Rosenbaum P, Leviton A, Paneth N, Dan B, et al. Proposed definition and classification of cerebral palsy, April 2005.; Executive Committee for the Definition of Cerebral Palsy. Dev Med Child Neurol 2005;47:571-6   DOI   ScienceOn
2 Neil J, Miller J, Mukherjee P, Huppi PS. Diffusion tensor imaging of normal and injured developing human brain-a technical review. NMR Biomed 2002;15:543-52   DOI   ScienceOn
3 Hoon AH, Lawrie WT, Melhem ER, Reinhardt EM, van Zijl PCM, Solaiyappan M, et al. Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways. Neurology 2002;59:752-6   DOI   PUBMED   ScienceOn
4 Glenn OA, Henry RG, Berman JI, Chang PC, Miller SP, Vigneron DB, et al. DTI-based three-dimensional tractography detects differences in the pyramidal tracts of infants and children with congenital hemiparesis. J Magn. Reson. Imaging 2003;18:641-8   DOI   ScienceOn
5 Son SM, Ahn YH, Sakong J, Moon HK, Ahn SH, Lee H, et al. Diffusion tensor imaging demonstrates focal lesions of the corticospinal tract in hemiparetic patients with cerebral palsy. Neurosci Lett 2007;420:34-8   DOI   ScienceOn
6 Kunimatsu A, Aoki S, Masutani Y, Abe O, Hayashi N, Mori H, et al. The optimal trackability threshold of fractional anisotropy for diffusion tensor tractography of the corticospinal tract. Magn Reson Med Sci 2004;3:11-7   DOI   ScienceOn
7 Mukherjee P, Miller JH, Shimony JS, Conturo TE, Lee BC, Almli CR, et al. Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging. Radiology 2001;221:349-58   DOI   ScienceOn
8 Mamata H, Mamata Y, Westin CF, Shenton ME, Kikinis R, Jolesz FA, et al. High resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy. AJNR 2002;23:67-75   ScienceOn
9 Pierpaoli C, Basser PJ. Toward a quantitative assessment of diffusion anisotrophy. MRM 1996;36:893-906
10 Han BS, Ahn SH, Jang SH. Cortical reorganization demonstrated by diffusion tensor tractography analyzed using functional MRI activation. Neuro Rehabilitation 2008;23:171- 4   ScienceOn
11 Truwit CL, Barkovich AJ, Kock TK, Ferriero DM. Cerebral palsy: MR findings in 40 patients. AJNR 1992;13:67-78   ScienceOn
12 Glenn OA, Ludeman NA, Berman JI, Wu YW, Lu Y, Bartha AI, et al. Diffusion tensor MR imaging tractography of the pyramidal tracts correlates with clinical motor function in children with congenital hemiparesis. AJNR 2007;28:1796-802   DOI   ScienceOn
13 Taudrof K, Melchoir JC, Pedersen H. CT findings in spastic cerebral palsy: Clinical, etiological and prognostic aspects. Neuropediatrics 1984;15:120-4   DOI   PUBMED
14 Bydder GM, Rutherford MA. Diffusion-weighted imaging of the brain in neonates and infants. Magn Reson Imaging Clin N Am 2001;9:83-98   PUBMED   ScienceOn
15 Huang H, Zhang J, Wakana S, Zhang W, Ren T, Richards LJ, et al. White and gray matter development in human fetal, newborn and pediatric brains. Neuroimage 2006;33:27-38   DOI   ScienceOn
16 Lee SK, Kim DI, Kim JN, Kim DJ, Kim HD, Kim DS, et al. Diffuion-tensor MR imaging and fiber tractography: a new method of describing aberrant fiber connections in developmental CNS anomalies. Radiographics 2005;25:53-68   DOI   ScienceOn
17 Mori S, Crain BJ, Chacko VP, van Zijl PCM. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999;45:265-9   DOI   ScienceOn
18 Schaefer PW, Grant PE, Gonzalez RG. Diffusion-weighted MR imaging of the brain. Radiology 2000;217:331-45   PUBMED   ScienceOn
19 Le TH, Mukherjee P, Henry RG, Berman JI, Ware M, Manley GT. Diffusion tensor imaging with three-dimensional fiber tractography of traumatic axonal shearing injury: an imaging correlate for the posterior callosal "disconnection" syndrome: case report. Neurosurgery 2005;56:189   PUBMED
20 Jang SH, Ahn SH, Cho YW. Transcallosal fibers from the corticospinal tract in adults with brain injury. Yeungnam Univ J Med 2007:24 Suppl:S424-9
21 Fan GG, Yu B, Quan SM, Sun BH, Guo QY. Potential of diffusion tensor MRI in the assessment of periventricular leukomalacia. Clin Radiol 2006;61:358-64   DOI   ScienceOn
22 Okada T, Miki Y, Fushimi Y, Hanakawa T, Kanagaki M, Yamamoto A, et al. Diffusion-tensor fiber tractography: intraindividual comparison of 3.0-T and 1.5-T MR imaging. Radiology 2006;238:668-78   DOI   ScienceOn
23 Ment LR, Bada HS, Barnes P, Grant PE, Hirtz D, Papile LA, et al. Practice parameter: neuroimaging of the neonate (report of the Quality Standards Subcommittee of the American Academy of Neurology an Practice Committee of the Child Neurology Society). Neurology 2002;58:1726-38   PUBMED   ScienceOn