Browse > Article
http://dx.doi.org/10.3345/kjp.2009.52.1.50

The outcomes of retinopathy of prematurity in relation to duration of low dose oxygen therapy  

Lee, Pil Sang (Department of Pediatrics, Daegu Fatima Hospital)
Choe, Jae Won (Department of Pediatrics, Daegu Fatima Hospital)
Lee, Sang Geel (Department of Pediatrics, Daegu Fatima Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.1, 2009 , pp. 50-55 More about this Journal
Abstract
Purpose : This study aimed to determine the influence of low-dose oxygen ($FiO_2$ <25%) therapy through nasal cannulae on the progress and prognosis of retinopathy of prematurity (ROP) as well as methods of preventing ROP. Methods : Our subjects comprised premature infants (gestation period <37 weeks; birth weight <1,750 g) born in Daegu Fatima Hospital between February 1, 2001 and January 31, 2006. We retrospectively reviewed and analyzed the medical records of 273 patients who were available for eye examination and follow up over 6 months. Results : The factors maximally influencing the occurrence of ROP were low gestation age and low birth weight. We observed that the incidence of ROP increased with the increasing duration of low-dose oxygen therapy. ROP onset was delayed during ongoing oxygen therapy; however, rapid progression of ROP occurred after the discontinuation of oxygen therapy among premature infants up to the prethreshold stage. Conclusion : To prevent of occurrence of severe ROP and its rapid progression, the period of low-dose oxygen therapy needs to be shortened. Moreover, frequent eye examinations should be performed after the discontinuation of oxygen therapy.
Keywords
Retinopathy of prematurity; Risk factors; Low dose oxygen therapy; Lung disease; Chronic;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wagner RS. Increased incidence and severity of retinopathy of prematurity in developing nations. J Pediatr Ophthalmol Strabismus 2003;40:208-12
2 Patz A, Eastham A, Higginbotham DH, Kleh T. Oxygen studies in retrolental fibroplasia II. The production of the microscopic changes of retrolental fibroplasia in experimental animals. Am J Ophthalmol 1953;36:1511-22   PUBMED   ScienceOn
3 Kinsey VE. Etiology of retrolental fibroplasia: preliminary report of a cooperative study of retrolental fibroplasia. Am J Ophthalmol 1955;40:166-74   PUBMED   ScienceOn
4 Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-9   PUBMED   ScienceOn
5 Maheshwari R, Kumar H, Paul VK, Singh M, Deorari AK, Tiwari HK. Incidence and risk factors of retinopathy of prematurity in a tertiary care newborn unit in New Delhi. Natl Med J India 1996;9:211-4   ScienceOn
6 Cho YU, Koo BS. Incidence and Risk Factors in Retinopathy of Prematurity. J Korean Ophthamol Soc 1993;34:851-9
7 Palmer EA, Flynn JT, Hardy RJ, Phelps DL, Phillips CL, Schaffer DB, et al. Incidence and early course of retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmology 1991;98:1628-40   PUBMED   ScienceOn
8 Hussain N, Clive J, Bhandari V. Current incidence of retinopathy of prematurity, 1989-1997. Pediatrics 1999;104:e26   DOI   PUBMED   ScienceOn
9 Smith LE. IGF-1 and retinopathy of prematurity in the preterm infant. Biol Neonate 2005;88:237-44   DOI   PUBMED   ScienceOn
10 Roth AM. Retinal vascular development in premature infants. Am J Ophthalmol 1977;84:636-40   PUBMED   ScienceOn
11 Good WV, Hardy RJ, Dobson V, Palmer EA, Phelps DL, Quintos M, et al. Early Treatment of Retinopathy of Prematurity Cooperative Group. The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study. Pediatrics 2005;116:15- 23   DOI   PUBMED   ScienceOn
12 The International Committee for the classification of the Late Stages of Retinopathy of Prematurity. An international classification of retinopathy of prematurity. II. The classification of retinal detachment. Arch Ophthalmol 1987;105:906-12   PUBMED   ScienceOn
13 Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, et al. National Institutes of Child Health and Human Development Neonatal Research Network. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics 2005;116:1353-60   DOI   ScienceOn
14 Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity. Snellen acuity and structural outcome at 5½ years after randomization. Arch Ophthalmol 1996;114:417-24   PUBMED   ScienceOn
15 Kim TI, Sohn JH, Yoon YH, Kim KS, Pi SY. Postnatal risk factors of retinopathy of prematurity. J Korean Ophthalmol Soc 2000;41:1229-35
16 Seiberth V, Linderkamp O. Risk factors in retinopathy of prematurity. a multivariate statistical analysis. Ophthalmologica 2000;214:131-5   DOI   ScienceOn
17 Naiman J, Green WR, Patz A. Retrolental fibroplasia in hypoxic newborn. Am J Ophthalmol 1979;88:55-8   PUBMED   ScienceOn
18 Gibson DL, Sheps SB, Schechter MT, Wiggins S, McCormic AQ. Retinopathy of prematurity: a new epidemic? Pediatrics 1989;83:486-92   PUBMED   ScienceOn
19 Silverman WA. A cautionary tale about supplemental oxygen: the albatross of neonatal medicine. Pediatrics 2004;113:394-6   DOI   PUBMED   ScienceOn
20 Flynn JT, Bancalari E, Bawol R, Goldberg R, Cassady J, Schiffman J, et al. Retinopathy of prematurity. A randomized, prospective trial of transcutaneous oxygen monitoring. Ophthalmology 1987;94:630-8   DOI   PUBMED
21 Ahn BS, Oh SY. Risk factors of retinopathy of prematurity. J Korean Ophthalmol Soc 1999;40:757-64   DOI   ScienceOn
22 Kinsey VE, Arnold HJ, Kalina RE, Stern L, Stahlman M, Driscoll JM Jr, et al. PaO2 level and retrolental fibroplasia. a report of the cooperative study. Pediatrics 1977;60:655-68   PUBMED   ScienceOn
23 Simons BD, Flynn JT. Retinopathy of prematurity and associated factors. Int Ophthalmol Clin 1999;39:29-48   PUBMED
24 Pierce EA, Foley ED, Smith LE. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol 1996;114;1219-28   PUBMED   ScienceOn
25 Terry TL. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens. I. Priliminary reports. Am J Opthalmol 1942;25:203-4
26 Repka MX, Hudak ML, Parsa CF, Tielsch JM. Calf lung surfactant extract prophylaxis and retinopathy of prematurity. Ophthalmology 1992;99:531-6   PUBMED   ScienceOn
27 Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia- initiated angiogenesis. Nature 1992;359:843-5   DOI   ScienceOn
28 Hellstrom A, Perruzzi C, Ju M, Engstrom E, Hard AL, Liu JL, et al. Low IGF-1 suppresses VEGF survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci USA 2001;98: 5804-8   DOI   ScienceOn
29 Adamkin DH, Shott RJ, Cook LN, Andrews BF. Nonhyperoxic retrorental fibroplasia. Pediatrics 1977;60:828-30   PUBMED   ScienceOn
30 Lineham JD, Smith RM, Dahlenburg GW, King RA, Haslam RR, Stuart MC, et al. Circulating insulin-like growth factor I levels in newborn premature and full-term infants followed longitudinally. Early Hum Dev 1986;13:37-46   DOI   ScienceOn