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http://dx.doi.org/10.3345/kjp.2009.52.12.1377

Analysis of gonadotropin-releasing hormone (GnRH) test results in girls with precocious puberty  

Choi, Jung Yun (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Kang, Hyun-Ju (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Cho, Won Kyoung (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Cho, Kyoung Soon (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Park, So Hyun (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Hahn, Seung Hoon (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Jung, Min Ho (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Seo, Byung Kyu (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Lee, Byung Churl (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.12, 2009 , pp. 1377-1382 More about this Journal
Abstract
Purpose:The gonadotropin-releasing hormone (GnRH) test results of girls with precocious puberty were analyzed to determine whether this test can efficiently and clearly differentiate between central precocious puberty (CPP) and other disorders. Methods:Clinical and laboratory data of 54 girls with precocious pubertal signs were reviewed. Intravenous GnRH test was performed with blood samples obtained at 0, 30, 60, and 90 minutes. A peak luteinizing hormone (LH) level of ${\geq}5.0IU/L$ was indicative of CPP. Results:Of the 40 girls with CPP, 36 (90.0%), 3 (7.5%), and 1 (2.5%) showed peak LH levels at 30, 60, and 90 minutes, respectively. A percentage of girls whose peak LH ${\geq}5.0IU/L$ up to 30, 60, and 90 minutes was 92.5%, 100%, and 100%, respectively. The peak LH/follicle stimulating hormone (FSH) ratio of girls with CPP was 0.89${\pm}$0.49 and was <1 in 16 of the 40 girls (40.0%). Girls with peak LH/FSH ratio of >1.0 showed higher chronological age (CA) ($8.3{\pm}0.6$ vs. $7.7{\pm}1.0$ years, P=0.033), bone age (BA) ($10.9{\pm}0.8$ vs. $9.7{\pm}1.1$ years, P=0.001), and BA-CA difference ($2.6{\pm}0.7$ vs. $2.0{\pm}0.7$ years, P=0.009) than those of girls with peak LH/FSH ratio of ${\leq}1.0$. Higher percentage of girls with peak LH/FSH ratio of >1.0 showed advanced breast development (${\geq}TannerIII$) (93.7% vs. 41.7%, P=0.001). Conclusion:LH levels after 30 and 60 minutes of intravenous GnRH administration are the most useful for diagnosing CPP in girls.
Keywords
Precocious puberty; Gonadotropin-releasing hormone test;
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