Browse > Article
http://dx.doi.org/10.3345/kjp.2009.52.10.1082

Recent concepts on vitamin D in children and adolescents  

Yang, Hye Ran (Committee on Nutrition, Korean Pediatric Society, Department of Pediatrics, Seoul National University College of Medicine Seoul National University Bundang Hospital)
Seo, Jeong Wan (Department of Pediatrics, Ewha Womans University School of Medicine)
Kim, Yong Joo (Department of Pediatrics, Hanyang University College of Medicine)
Kim, Jae Young (Department of Pediatrics, Chungnam National University School of Medicine)
Ryoo, Eell (Department of Pediatrics, Gachon University, Gil Hospital, Incheon KSCH Pediatric Clinic)
Sim, Jae Geon (KSCH Pediatric Clinic)
Yom, Hye Won (Departments of Pediatrics, Seoul Metropolitan Dong-bu Hospital)
Chang, Ju Young (Department of Pediatrics, Seoul National University College of Medicine, Seoul Metropolitan Boramae Hospital)
Jung, Ji A (Department of Nutritional Science, Maeil Daires Co.,)
Choi, Kwang Hae (Department of Pediatrics, Youngnam University College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.10, 2009 , pp. 1082-1089 More about this Journal
Abstract
Vitamin D is an important fat-soluble vitamin that functions as a prohormone and affects bone mineralization and calcium homeostasis. Vitamin D deficiency causesboth musculoskeletal manifestations, including rickets, and extra-musculoskeletal symptoms. Because vitamin D is naturally present in only some foods, intake of daily foods cannot meet the dietary reference intake for vitamin D. Sunlight is the main source of vitamin D in humans therefore, the lack of sunlight can easily cause vitamin D deficiency in children and adolescents. Vitamin D deficiency can be diagnosed on the basis ofits typical clinical manifestation, laboratory tests, and radiologic findings. Detection of vitamin D deficiency in children or adolescents necessitates the simultaneous administration of vitamin D and calcium supplements. To prevent vitamin D deficiency, 200 IU of daily vitamin D intake is recommended in infants, and 400 IU of daily vitamin D intake is recommended in Korean children and adolescents.
Keywords
Vitamin D; Rickets; Deficiency; Children; Adolescents;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 ALa-Houbala M. 25-(OH)D levels during breast-feeding with or without maternal or infantile supplementation of vitamin D. J Pediatr Gastroenterol Nutr 1985;4:220-6   DOI   PUBMED
2 Roth HJ, Zahn I, Alkier R, Schmidt H. Validation of the first automated chemiluminescence protein-binding assay for the detection of 25-hydroxycalciferol. Clin Lab 2001;47:357-65   PUBMED   ScienceOn
3 Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25- hydroxyvitamin D. J Am Coll Nutr 2003; 22:142-6   DOI   PUBMED   ScienceOn
4 Wagner CL, Greer FR; American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics 2008; 122:1142-52   DOI   ScienceOn
5 Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth- cohort study. Lancet 2001;358:1500-3   DOI   ScienceOn
6 Williams B, Williams AJ, Anderson ST. Vitamin D deficiency and insufficiency in children with tuberculosis. Pediatr Infect Dis J 2008;27:941-2   DOI   ScienceOn
7 Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med 2009;179:765-71   DOI   ScienceOn
8 Gordon CM, Williams AL, Feldman HA, May J, Sinclair L, Vasquez A, et al. Treatment of hypovitaminosis D in infants and toddlers. J Clin Endocrinol Metab 2008;93:2716-21   DOI   ScienceOn
9 Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr 2007;85:6-18   DOI   ScienceOn
10 Weaver CM. Vitamin D, calcium homeostasis, and skeleton accretion in children. J Bone Miner Res 2007;22 Suppl 2: V45-9   DOI   ScienceOn
11 Abrams SA, Griffin IJ, Hawthorne KM, Chen Z, Gunn SK, Wilde M, et al. Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. J Bone Miner Res 2005;20:945-53   DOI   ScienceOn
12 Stearns G. Early experiences with vitamin D in the nutrition of infants and children: a retrospect. Nutr Rev 1954;12:193-6   DOI   PUBMED   ScienceOn
13 임현숙, 김을상, 안홍석, 김혜영. 영양섭취기준의 새로운 패러다임: 미국/캐나다의 Dietary Reference Intakes (DRIs) -영아기, 임신기 및 수유기의 미국/캐나다 DRIs 검토. 한국영양학회지 2004;37: 596-602
14 Berwick M, Armstrong BK, Ben-Porat L, Fine J, Kricker A, Eberle C, et al. Sun exposure and mortality from melanoma. J Natl Cancer Inst 2005;97:195-9   DOI   PUBMED   ScienceOn
15 Yanoff LB, Parikh SJ, Spitalnik A, Denkinger B, Sebring NG, Slaughter P, McHugh T, etc, The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clin Endocrinol (Oxf) 2006;64:523-9   DOI   ScienceOn
16 Greer FR. 25-Hydroxyvitamin D: functional outcomes in infants and young children. Am J Clin Nutr 2008;88:529S-33S   ScienceOn
17 Poskitt EM, Cole TJ, Lawson DE. Diet, sunlight, and 25- hydroxy vitamin D in healthy children and adults. Br Med J 1979;1:221-3   DOI   PUBMED
18 Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135:317-22   DOI   PUBMED   ScienceOn
19 Huh SY, Gordon CM. Vitamin D deficiency in children and adolescents: epidemiology, impact and treatment. Rev Endocr Metab Disord 2008;9:161-70   DOI   ScienceOn
20 Binkley N, Krueger D, Cowgill CS, Plum L, Lake E, Hansen KE et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab 2004;89:3152-7   DOI   ScienceOn
21 Lee JM, Smith JR, Philipp BL, Chen TC, Mathieu J, Holick MF. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr 2007;46:42-4   DOI   ScienceOn
22 Ladhani S, Srinivasan L, Buchanan C, Allgrove J. Presentation of vitamin D deficiency. Arch Dis Child 2004;89:781-4   DOI   ScienceOn
23 Hollis BW, Horst RL. The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going. J Steroid Biochem Mol Biol 2007;103:473-6   DOI   ScienceOn
24 Berry JL, Davies M, Mee AP. Vitamin D metabolism, rickets, and osteomalacia. Semin Musculoskelet Radiol 2002;6:173-82   DOI   PUBMED   ScienceOn
25 Wagner CL, Husley TC, Fanning D, Ebeling M, Hollis BW. High dose vitamin D3 supplementation in a cohort of breast- feeding mothers and their infants: a six-month follow-up pilot study. Breastfeed Med 2006;1:59-60   DOI
26 Villamor E, Kupka R, Fawzi WW. Vitamins. In Nutrition in Pediatrics. Basic Science and Clinical Applications. Third edition. Walker WA, Watkins JB, and Duggan C, eds. BC Decker Inc, Hamilton, 2003;111-33
27 Holick MF.  McCollum Award Lecture, 1994: vitamin-D new horizons for the 21st century. Am J Clin Nutr 1994;60:619- 30   DOI   PUBMED   ScienceOn
28 Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev 2008;13:6-20
29 Sharma OP. Hypercalcemia in granulomatous disorders: a clinical review. Curr Opin Pulm Med 2000;6:442-7   DOI   PUBMED   ScienceOn
30 Greer FR, Krebs NF, American Academy of Pediatrics, Committee on Nutrition. Optimizing bone health and calcium intakes of infants, children, and adolescents. Pediatrics 2006; 117:578-85   DOI   ScienceOn
31 Bowman SA. Beverage choiceof young feemale; changes and impact on nutrient intakes. J Am Diet Assoc. 2002;102:1234   DOI   PUBMED   ScienceOn
32 Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, Abraham A, et al. High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol 2009; 46:183-9   DOI   ScienceOn
33 Munns C, Zacharin MR, Rodda CP, Batch JA, Morley R, Cranswick NE, et al.; Paediatric Endocrine Group; Paediatric Bone Australasia. Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. Med J Aust 2006;185:268-72   PUBMED
34 Willis CM, Laing EM, Hall DB, Hausman DB, Lewis RD. A prospective analysis of plasma 25-hydroxyvitamin D concentrations in white and black prepubertal female in the southeastern United States. Am J Clin Nutr 2007;85:124-30   DOI   ScienceOn
35 Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serym 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006;296:2832-8   DOI
36 Davies M, Berry JL, Mee AP. Bone disorders associated with gastrointestinal and hepatobiliary disease. In: Feldman D, Pike JW, Glorieux FH, editors. Vitamin D. San Diego, CA: Elsevier, 2005;1293-311
37 Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab 2002;13:100-5   DOI   ScienceOn
38 Institute of medicine, food and nutrition board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1997;250-87
39 Hatum S, Ozkan B, Orbak Z. Vitamin D-deficiency rickets in early infancy. J Nitr 2005;135:279-82   DOI   ScienceOn
40 Prentice A, Goldberg GR, Schoenmakers I. Vitamin D across the lifecycle: physiology and biomarkers. Am J Clin Nutr 2008;88:500S-6S   DOI   ScienceOn
41 Lamberg-Allardt CJ, Viljakainen HT. 25-Hydroxyvitamin D and functional outcomes in adolescents. Am J Clin Nutr 2008; 88:534S-6S   DOI   ScienceOn
42 Thacher TD, Fischer PR, Strand MA, Pettifor JM. Nutritional rickets around the world: causes and future directions. Am Trop Pediatr 2006;26:1-16   DOI   ScienceOn
43 Ladhani S, Srinivasan L, Buchanan C, Allgrove J. Presentation of vitamin D deficiency. Arch Dis Child 2004;89:781-4   DOI   ScienceOn
44 Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008; 122:398-417   DOI   ScienceOn
45 Markestad T, Aksnes L, Ulstein M, Aarskog D. 25-Hydroxyvitamin D and 1,25-dihydroxyvitamin D of D2 and D3 origin in maternal and umbilical cord serum after vitamin D2 supplementation in human pregnancy. Am J Clin Nutr 1984; 40:1057-63   ScienceOn
46 Smith EL, Walworth NC, Holick MF. Effect of 1 alpha,25- dihydroxyvitamin D3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions. J Invest Dermatol 1986;86: 709-14   DOI   ScienceOn
47 Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest 2006;116:2062-72   DOI   ScienceOn