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http://dx.doi.org/10.3345/kjp.2008.51.7.722

The relationship between adiponectin, leptin, insulin, insulin-like growth factor and IGF binding protein-3 in cord blood and neonatal anthropometric parameters  

Cho, Hai Jung (Department of Pediatrics, College of Medicine, Hallym University)
Kim, Ji Young (Department of Pediatrics, College of Medicine, Hallym University)
Kim, Me Jin (Department of Pediatrics, College of Medicine, Hallym University)
Hwang, Il Tae (Department of Pediatrics, College of Medicine, Hallym University)
Lee, Hae Ran (Department of Pediatrics, College of Medicine, Hallym University)
Publication Information
Clinical and Experimental Pediatrics / v.51, no.7, 2008 , pp. 722-728 More about this Journal
Abstract
Purpose : This study was designed to examine the effects of adiponectin, leptin, insulin, insulin-like growth factor (IGF)-I and IGF binding protein (BP)-3 levels in cord blood on weight, length, and adiposity at birth in healthy term infants. In addition, we evaluated the mechanism to change the hormone levels in appropriate for gestational age (AGA) during the first month. Methods : We collected cord blood from 200 term neonates (109 males, 91 females) with no perinatal problems, and measured the hormone levels and anthropometric parameters including weight, length, and skin-fold thickness. Term neonates were divided into 3 groups as follows: birth weight appropriate for gestational age (AGA) (n=132), birth weight less for gestational age (SGA) (n=29), and birth weight more for gestational age (LGA) (n=39). Venous blood samples of 15 fullterm healthy neonates were obtained at 3, 7, and 30 d after birth. Results : The adiponectin, insulin, and IGF-I levels were significantly lower in the SGA group than in the AGA and LGA groups. The leptin levels were significantly higher in the LGA group than in the AGA and SGA groups. Cord blood adiponectin, leptin, insulin, IGF-I, and IGFBP-3 levels correlated significantly and positively with birth weight and the sum of the skin-fold thickness. A significant positive correlation was observed between adiponectin, leptin, and IGF-I levels and birth weight. Adiponectin level correlated significantly with that leptin level (r=0.191, P=0.038), but not with insulin, IGF-I and IGFBP-3 levels. IGF-I levels were higher in females than in males. At 7 d after birth, the leptin level decreased along with physiologic weight loss, and then increased. IGF-I, also decreased at 3 d, significantly increased 1 month later. Conclusion : We suggest that adiponectin, leptin, insulin, IGF-I, and IGFBP-3 play an important role in regulating fetal growth. Adiponectin may be involved in regulating fetal growth through mechanisms different from those mediated by insulin or IGF-I. High levels of IGF-I in female neonates indicates a gender difference which serves as evidence for in utero sexual dimorphism. It is likely that IGF-I has a more important role than that of hormones in postnatal growth.
Keywords
Adiponectin; Leptin; Insulin; IGF-I; IGFBP-3; Fetal growth;
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1 Orbak Z, Darcan S, Coker M, Goksen D. Maternal and fetal serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), leptin levels and early postnatal growth in infants born asymmetrically small for gestational age. J Pediatr Endocrinol Metab 2001;14:1119-27
2 Kajantie E, Hytinantti T, Hovi P, Andersson S. Cord plasma adiponectin: a 20-fold rise between 24 weeks gestation and term. J Clin Endocrinol Metab 2004;89:4031-6   DOI
3 Picaud JC, Rigo J, Nyamugabo K, Milet J, Senterre J. Evaluation of dual-energy X -ray absorptiometry for bodycomposition assessment in piglets and term human neonates. Am J Clin Nutr 1996;63:157-63   DOI
4 Koistinen HA, Koivisto VA, Andersson S, Karonen SL, Kontula K, Oksanen L, et al. Leptin concentration in cord blood correlates with intrauterine growth. J Clin Endocrinol Metab 1997;82:3328-30   DOI
5 Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adiposespecific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83   DOI   ScienceOn
6 Yannakoulia M, Yiannakouris N, Bluher S, Matalas AL, Klimis-Zacas D, Mantzoros CS. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab 2003; 88:1730-6   DOI
7 Gluckman PD. Clinical review 68: The endocrine regulation of fetal growth in late gestation: the role of insulin-like growth factors. J Clin Endocrinol Metab 1995;80:1047-50   DOI
8 Tsai PJ, Yu CH, Hsu SP, Lee YH, Chiou CH, Hsu YW et al. Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. Clin Endocrinol (Oxf) 2004;61:88-93   DOI   ScienceOn
9 Lofqvist C, Andersson E, Gelander L, Rosberg S, Blum WF, Albertsson Wikland K Reference values for IGF-I throughout childhood and adolescence: a model that accounts simultaneously for the effect of gender, age, and puberty. J Clin Endocrinol Metab 2001;86:5870-6   DOI
10 Schubring C, Siebler T, Kratzsch J, Englaro P, Blum WF, Triep K, et al. Leptin serum concentrations in healthy neonates within the first week of life: relation to insulin and growth hormone levels, skinfold thickness, body mass index and weight. Clin Endocrinol (Oxf) 1999;51:199-204   DOI
11 White DR, Widdowson EM, Woodard HQ, Dickerson JW. The composition of body tissues (II). Fetus to young adult. Br J Radiol 1991;64:149-59   DOI   ScienceOn
12 Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 1999;103:1175-82   DOI   ScienceOn
13 Fowden AL. The role of insulin in prenatal growth. J Dev Physiol 1989;12:173-82
14 Boulton TJ, Dunlop M, Court JM. The growth and development of fat cells in infancy. Pediatr Res 1978;12:908-11   DOI   ScienceOn
15 Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-53   DOI   ScienceOn
16 Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 2003;26:2442-50   DOI   ScienceOn
17 Shimabukuro M, Higa N, Asahi T, Oshiro Y, Takasu N, Tagawa T, et al. Hypoadiponectinemia is closely linked to endothelial dysfunction in man. J Clin Endocrinol Metab 2003;88:3236-40   DOI
18 Hassink SG, de Lancey E, Sheslow DV, Smith-Kirwin SM, O'Connor DM, Considine RV, et al. Placental leptin: an important new growth factor in intrauterine and neonatal development? Pediatrics 1997;100:E1   DOI   ScienceOn
19 Ong KK, Ahmed ML, Sherriff A, Woods KA, Watts A, Golding J, et al. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. ALSP AC study team. Avon longitudinal study of pregnancy and childhood. J Clin Endocrinol Metab 1999;84:1145-8   DOI
20 Yamauchi T, KamonJ, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-6   DOI   ScienceOn
21 Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 2002;51:2734-41   DOI   ScienceOn
22 Forsum E, Sadurskis A. Growth, body composition and breast milk intake of Swedish infants during early life. Early Hum Dev 1986;14:121-9   DOI   ScienceOn
23 Geary MP, Pringle PJ, Rodeck CH, Kingdom JC, Hindmarsh PC. Sexual dimorphism in the growth hormone and Insulinlike growth factor axis at birth. J Clin Endocrinol Metab 2005;88:3708-14   DOI
24 Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, et al. Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab 2003;88:2014-8   DOI
25 Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002;87:4652-6   DOI
26 Goran MI, Kaskoun M, Shuman WP. Intra-abdominal adipose tissue in young children. Int JObes Relat Metab Disord 1995;19:279-83
27 Haggarty P. Placental regulation of fatty acid delivery and its effect on fetal growth-a review. Placenta 2002;23 Suppl A:S28-38   DOI   ScienceOn
28 Kotani Y, Yokota I, Kitamura S, Matsuda J, Naito E, Naito E, et al. Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birth weight. Clin Endocrinol (Oxf) 2004;61:418-23   DOI   ScienceOn
29 Harrington TA, Thomas EL, Modi N, Frost G, Coutts GA, Bell JD. Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants. Lipids 2002; 37:95-100   DOI   ScienceOn
30 Soriguer Escofet FJ, Esteva de Antonio I, Tinahones FJ, Pareja A. Adipose tissue fatty acids and size and number of fat cells from birth to 9 years of age--a cross-sectional study in 96 boys. Metabolism 1996:45:1395-401   DOI   ScienceOn