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http://dx.doi.org/10.3345/kjp.2008.51.5.523

Transforming growth factor-β gene promoter polymorphism : its association with renal involvement in Henoch-Schölein Purpura in childhood  

Lee, Seung Ho (Department of Pediatrics, Wonju College of Medicine, Yonsei University)
Jee, Hwa Young (Department of Pediatrics, Wonju College of Medicine, Yonsei University)
Kim, Hwang Min (Department of Pediatrics, Wonju College of Medicine, Yonsei University)
Yeh, Byung Il (Department of Biochemistry, Wonju College of Medicine, Yonsei University)
Publication Information
Clinical and Experimental Pediatrics / v.51, no.5, 2008 , pp. 523-527 More about this Journal
Abstract
Purpose : Several cytokines play important roles in the inflammatory process of Henoch-$Sch\ddot{o}lein$ Purpura (HSP). It is likely that transforming growth $factor-{\beta}$ ($TGF-{\beta}$) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether $TGF-{\beta}$ promoter polymorphism is associated with the renal involvement of childhood HSP. Methods : Thirty-four patients younger than 15 years, who had been diagnosed with HSP, as well as 27 controls, were examined. Patients and controls were genotyped for $TGF-{\beta}$ C-509T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results : The T allelic frequencies in patients and controls showed no difference (45% vs. 48.8%). No allele or genotype differences between the group of HSP group and control group were observed. The frequencies of $TGF-{\beta}$ 509 genotypes TT, TC, and CC were no different between patients and controls (26% vs. 22%). The TT genotype of polymorphism of the $TGF-{\beta}$ C-509T gene had no relation to the susceptibility of children to HSP and renal involvement in HSP. Conclusion : $TGF-{\beta}$ T allele may not be related to the susceptibility of children to HSP. The TT genotype of polymorphism of the $TGF-{\beta}$ C 509T gene does not appear to have an influence on renal involvement in childhood HSP.
Keywords
Henoch-$Sch\ddot{o}lein$ Purpura; $TGF-{\beta}$ polymorphism; Renal involvement;
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