Browse > Article

Serum ghrelin and leptin concentrations in children with cancer : comparisons with normal children  

Park, So Hyun (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Jung, Min Ho (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Chung, Nac Gyun (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Suh, Byung-Kyu (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Lee, Byung Churl (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.9, 2007 , pp. 905-911 More about this Journal
Abstract
Purpose : Ghrelin, being secreted from the stomach, stimulates growth hormone secretion and controls energy homeostasis by increasing appetite. Leptin, being secreted from the adipocytes, controls weight and energy homeostasis by decreasing appetite. Leptin concentration is reported to increase after childhood cancer therapy. This study was aimed to compare ghrelin and leptin concentrations in normal children and children who received cancer therapy. Methods : We enrolled forty-three patients who were diagnosed with cancer and received radiotherapy or chemotherapy during Dec. 2004 through Dec. 2005 in St. Marys hospital and Kangnam St. Marys hospital. Forty-five healthy children were selected as a control group whose age, gender, weight and height were similar to those of cancer group. The serum leptin and ghrelin concentrations were also measured by radioimmunoassay. Results : The cancer group showed higher BMI and leptin concentrations. The control group showed higher concentrations of ghrelin. Both control and cancer groups revealed positive correlations between leptin concentrations and BMI. Ghrelin concentrations in the control group showed negative correlations with age, height, weight and BMI but no significant correlation was found in the cancer group. All the parameters in the group treated with chemotherapy only were not different from those in the group treated with chemotherapy and irradiation. But the level of ghrelin in the acute myeloid leukemia group was much higher than those in the acute lymphoblastic leukemia group. Conclusion : Patients with pediatric cancer treatment have presented higher BMI and leptin concentrations but lower ghrelin concentrations than those in healthy children. Because of the relatively short duration and cross sectional method of the study, however, further long term and prospective study will be required in the future.
Keywords
Cancer; Ghrelin; Leptin; Acute myeloid leukemia; Acute lymphoblastic leukemia;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Jarfelt M, Lannering B, Bosaeus I, Johannsson G, Bjarnason R. Body composition in young adult survivors of childhood acute lymphoblastic leukaemia. Eur J Endocrinol 2005;153: 81-9   DOI   ScienceOn
2 Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000; 85:4908-11   DOI
3 Davies JH, Evans BA, Jones E, Evans WD, Jenney ME, Gregory JW. Osteopenia, excess adiposity and hyperleptinaemia during 2 years of treatment for childhood acute lymphoblastic leukaemia without cranial irradiation. Clin Endocrinol (Oxf) 2004;60:358-65   DOI   ScienceOn
4 Jo DS, Lee JU, Kim SY, Kim SJ, Kang CW, Hwang PH, et al. J Korean Soc Pediatr Endocrinol 2004;9:179-85
5 Volante M, Allia E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002;87:1300-8   DOI
6 Hattori N, Saito T, Yagyu T, Jiang BH, Kitagawa K, Inagaki C. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab 2001;86:4284-91   DOI
7 Konopleva M, Mikhail A, Estrov Z, Zhao S, Harris D, Sanchez- Williams G, et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999;93:1668-76
8 Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001;145:669-73   DOI   ScienceOn
9 Corbetta S, Peracchi M, Cappiello V, Lania A, Lauri E, Vago L, et al. Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab 2003;88:3117-20   DOI
10 Bhatia S, Landier W, Robison LL. Late effects of childhood cancer therapy. In DeVita VT, Hellman S, Rosenberg SA, editors. Progress in oncology 2002. Boston: Jones and Bartlett Publishers 2002:171-201
11 Whatmore AJ, Hall CM, Jones J, Westwood M, Clayton PE. Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf) 2003;59:649-54   DOI   ScienceOn
12 Brennan BM, Rahim A, Blum WF, Adams JA, Eden OB, Shalet SM. Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity? Clin Endocrinol (Oxf) 1999;50:163-9   DOI   ScienceOn
13 Muszynska-Roslan K, Krawczuk-Rybak M, Topczewska M, Sawicka-Zukowska M. Relationship between body mass index and leptin levels in children treated for acute lymphoblastic leukemia during and after maintenance therapy. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12:91-5
14 Martinez-Fuentes AJ, Moreno-Fernandez J, Vazquez-Martinez R, Duran-Prado M, de la Riva A, Tena-Sempere M, et al. Ghrelin is produced by and directly activates corticotrope cells from adrenocorticotropin-secreting adenomas. J Clin Endocrinol Metab 2006;91:2225-31   DOI
15 Otero M, Nogueiras R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O. Chronic inflammation modulates ghrelin levels in humans and rats. Rheumatology (Oxford) 2004;43:306-10   DOI   ScienceOn
16 Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001;50:707-9   DOI   ScienceOn
17 Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60   DOI   ScienceOn
18 Kourti M, Tragiannidis A, Makedou A, Papageorgiou T, Rousso I, Athanassiadou F. Metabolic syndrome in children and adolescents with acute lymphoblastic leukemia after the completion of chemotherapy. J Pediatr Hematol Oncol 2005; 27:499-501   DOI   ScienceOn
19 Mann DR, Johnson AO, Gimpel T, Castracane VD. Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans. J Clin Endocrinol Metab 2003;88:3339-45   DOI
20 Camurdan MO, Bideci A. Demirel F, Cinaz P. Serum ghrelin, IGF-1 and IGFBP-3 levels in children with normal variant short stature. Endocr J 2006;53:479-84   DOI   ScienceOn
21 Bunt JC, Salbe AD, Tschop MH, DelParigi A, Daychild P, Tataranni PA. Cross-sectional and prospective relationships of fasting plasma ghrelin concentrations with anthropometric measures in Pima Indian children. J Clin Endocrinol Metab 2003;88:3756-61   DOI
22 De Vriese C, Gregoire F, De Neef P, Robberecht P, Delporte C. Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation. Endocrinology 2005;146:1514-22   DOI   ScienceOn
23 Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics. CA Cancer J Clin 2003;53:5-26   DOI   ScienceOn
24 Nishi Y, Isomoto H, Ueno H, Ohnita K, Wen CY, Takeshima F, et al. Plasma leptin and ghrelin concentrations in patients with Crohns disease. World J Gastroenterol 2005;11:7314-7   DOI
25 Tsiotra PC, Pappa V, Koukourava A, Economopoulos T, Tsigos C, Raptis SA. Expression of leptin receptors in mononuclear cells from myelodysplastic syndromes and acute myeloid leukemias. Acta Haematol 2005;114:71-7   DOI   ScienceOn
26 Flier JS. Clinical review 94: Whats in a name? In search of leptins physiologic role. J Clin Endocrinol Metab 1998;83: 1407-13   DOI