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Isolation rate of 4 type virus of acute gastroenteritis in full-term neonates during neonatal period  

Moon, Soo Kyoung (Department of Pediatrics, School of Medicine, Eulji University)
Lee, Jae In (Seoul Research Institute of Public Health & Environment)
Yoon, Hye Sun (Department of Pediatrics, School of Medicine, Eulji University)
Ahn, Young Min (Department of Pediatrics, School of Medicine, Eulji University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.9, 2007 , pp. 855-861 More about this Journal
Abstract
Purpose : The most common causes of acute viral gastroenteritis in newborn period are rotavirus, astrovirus, norovirus and enteric adenovirus. This study was designed to investigate the clinical characteristics, clinical symptoms, isolation rate and distribution of these viruses in full-term neonates during neonatal period. We also studied the influence on the viral isolation rate by postnatal care place and feeding type. Methods : We evaluated 112 healthy full-term neonates who were admitted to Eulji hospital, presenting with symptoms of acute viral gastroenteritis from September 2004 to August 2005. Epidemiologic, clinical and laboratory data were reviewed. Enzyme-linked immunosorbent assay (ELISA) for rotavirus, astrovirus and norovirus and RT-PCR for enteric adenovirus were performed in study subjects.Results : The mean age at the admission was $11.4{\pm}5.4days$, mean weight loss was $5.9{\pm}5.1%$, mean hospitalization duration was $6.3{\pm}3.4days$. Moderate and severe weight loss were expressed in 51.7% and metabolic acidosis was in 13.4%. The percent of living in postnatal care facility (PCF) was 74.1 % and the percent of mixed feeding was 64.3%. Isolation rate of virus was 33%. The most prevalent virus was rotavirus (59.5%), followed by astrovirus (29.7%) and norovirus (10.8%). There was no differences in virus isolation rate by postnatal care place and by feeding type. The rotavirus was main virus in both home group and PCF group. But astrovirus was more detected in PCF and norovirus was more detected in home (P<0.05). According to monthly distribution of virus, acute viral gastroenteritis in newborn period was concentrated in September to December. Conclusion : The isolation rate of 4 type viruses was 33% and rotavirus was the leading cause of acute gastroenteritis during neonatal period. There was no differences in clinical characteristics on each viral groups.
Keywords
Virus; Gastroenteritis; Neonate;
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1 Clark B, Mckendrick M. A review of viral gastroenteritis. Curr Opin Infect Dis 2004;17:461-9   DOI   ScienceOn
2 Seo JK, Sim JG. Overview of rotavirus infections in Korea. Pediatr Int 2000;42:406-10   DOI   ScienceOn
3 Rotbart HA, Levin MJ, Yolken RH, Manchester DK, Jantzen J. An outbreak of rotavirus-associated neonatal necrotizing enterocolitis. J Pediatr 1983;103:454-9   DOI
4 Remington JS, Klein JO. Infectious disease of the fetus and newborn infant. 5th ed. Philadelphia: WB Saunders CO, 2001;1187-95
5 Weinberg RJ, Tipton G, Klish WJ, Brown MR. Effect of breast-feeding on morbidity in rotavirus gastroenteritis. Pediatrics 1984;74:250-3
6 Korea National Institute of Health. Rotavirus in postnatal care facility. Commun Dis Mon Rep 2003;14:284
7 Chen SM, Ni YH, Chen HL, Chang MH. Microbial etiology of acute gastroenteritis in hospitalized children in Taiwan. J Formos Med Assoc 2006;105:964-70   DOI   ScienceOn
8 Golding J, Emmett PM, Rogers IS. Gastroenteritis, diarrhoea and breast feeding. Early Hum Dev 1997;49 Suppl:83-103   DOI   ScienceOn
9 Totterdell BM, Chrystie IL, Banatvala JE. Rotavirus infection in a maternity unit. Arch Dis Child 1976;51:924-8   DOI   ScienceOn
10 So KJ, Lee MH, Ma SH, Kim BC, Yang JM. Rotavirus P and G genotypes circulating in Kyungsangnamdo, Korea, during 2000-2001. Korean J Pediatr Inf 2004;11:59-72
11 Wilhelmi I, Roman E, Snchez-Fauquier A. Viruses causing gasroenteritis. Clin Microbiol Infect 2003;9:247-62   DOI   ScienceOn
12 Bishop RF, Davidson GP, Holmes IH, Ruck BJ. Virus particles in epithelial cells of duodenal mucosa from children with acute non bacterial gastroenteritis. Lancet 1973;2:1281-3
13 Haffejee IE. Neonatal rotavirus infections. Rev Inf Dis 1991; 13:957-62   DOI
14 Dewey KG, Heinig MJ, Nommsen-Rivers LA. Differences in morbidity between breast-fed and formula-fed infants. J Pediatr 1995;126:696-702   DOI   ScienceOn
15 Korea Center for Disease Control and Prevention. Laboratory surveillance on acute gastroenteritis. Commun Dis Mon Rep 2007;18:2-9
16 Bishop RF, Cameron DJ, Veenstra AA, Barnes GL. Diarrhea and rotavirus infection associated with differing regimens for postnatal care of newborn babies. J Clin Microbiol 1979; 9:525-9
17 Ambrozová H, Schramlová J. Viral gastroenteritis in children. Klin Mikrobiol Infekc Lek 2005;11:83-91
18 Walter JE, Mitchell DK. Astrovirus infection in children. Curr Opin Infect Dis 2003;16:247-53   DOI   ScienceOn
19 Tufvesson B, Polberger S, Svanberg L, Sveger T. A prospective study of rotavirus infections in neonatal and maternity wards. Acta Paediatr Scand 1986;75:211-5   DOI
20 Moon KR. Rotavirus. J Korean Pediatr Soc 1993;36:1339-42
21 Dearlove J, Latham P, Dearlove B, Pearl K, Thomson A, Lewis IG. Clinical range of neonatal rotavirus gastroenteritis. Br Med J 1983;286:1473-5   DOI
22 Lee SY, Kim HJ, Kim MY, Kim WD, Lee DS, Kim DK, et al. The difference between clinical manifestations and feeding or delivery methods in healthy full-term neonates and those with nosocomial rotaviral infection. J Korean Pediatr Soc 2003;46:454-8
23 Scariati PD, Grummer-Strawn LM, Fein SB. A longitudinal analysis of infant morbidity and the extent of breastfeeding in the United States. Pediatrics 1997;99:E5
24 Chung JK, Song HJ, Kim SH, Seo JJ, Kee HY, Kim ES, et al. study of viral diarrhea in Gwangju area during 2000- 2002. J Bacteriol Virol 2006;36:195-203   과학기술학회마을   DOI
25 Totterdell BM Rotavirus infection in human neonates. JAMA 1978;173:527-30
26 Gaggero A, O'Ryan M, Noel JS, Glass RI, Monroe SS, Mamani N, et al. Prevalence of astrovirus infection among Chilean children with acute gastroenteritis. J Clin Microbiol 1998;36:3691-3.
27 Lopman B, Vennema H, Kohli E, Pothier P, Sanchez A. Negredo A, et al. Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant. Lancet 2004;363:682-8   DOI   ScienceOn
28 Park MK, Park JO, Kim CH. Compasion of clinical manifestations of rotaviral gastroenteritis between neonates and infants. Korean J Pediatr Gastroenterol Nutr 2006;9:153-61
29 Hogan R, Martinez J. Breastfeeding as an intervention within diarrheal diseases control programs: WHO/CDD activities. Int J Gynaecol Obstet 1990;31:115-9   DOI   ScienceOn
30 Berman RE, Kliegman RM, Jenson HB. Nelson text book of pediatrics. 17th ed. Philadelphia: Saunders, 2004;1081-3
31 Kramer MS, Chalmers B, Hodnett ED, Sevkovskaya Z, Dzikovich I, Shapiro S, et al. Promotion of Breastfeeding Intervention Trial (PROBIT): a randomized trial in the Republic of Belarus. JAMA 2001;285:413-20   DOI   ScienceOn