Browse > Article

Unprovoked seizures in children with complex febrile convulsion; short-term outcome  

Choi, Ji Yeon (Department of Pediatrics, College of Medicine, Konyang University)
Cheon, Eun Jung (Department of Pediatrics, College of Medicine, Konyang University)
Lee, Young Hyuk (Department of Pediatrics, College of Medicine, Konyang University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.8, 2007 , pp. 757-760 More about this Journal
Abstract
Purpose : Febrile convulsions (FC) were considered to be a benign seizure syndrome that is distinct from epilepsy. But it is thought that children with complex features i.e., partial or prolonged seizures or multiple episodes of FC would bear a higher risk of developing unprovoked seizures. The aim of this study is to look into the relative significance of each criteria that define complex febrile convulsions (CFC) as a predictor of subsequent epilepsy. Methods : All children were retrospectively identified for a febrile seizure through pediatric departments of the Konyang University Hospital. Information was collected from medical records and interviews with parents. Patients with abnormal neurological examinations at presentation were excluded. Results : This study was performed from March 2000 to December 2003. Sixty-three out of 314 children (20.0%) with febrile convulsion fulfilled the criteria for CFC and forty-four children of them have been followed for 12 months or more. Ten of these (23.2%) had unprovoked seizures for 14-62 months (median $34.2{\pm}11.6$ months). The patients with partial FC showed a trend toward a higher risk (57.1%) of developing epilepsy than the patients with multiple or prolonged febrile convulsions (26.7%, 24.1% respectively). Conclusion : We found that the partial feature of febrile convulsion is associated with subsequent epilepsy.
Keywords
Complex febrile convulsion; Epilepsy;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. N Engl J Med 1987;316:493-8
2 Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976; 295:1029-3   DOI   ScienceOn
3 Lee WL. Long-term outcome of children with febrile seizures. Ann Acad Med Singapore 1989;18:32-4
4 Consensus Development Panel. Febrile seizure; long termmanagement of children with fever associated seizures. Pediatrics 1980;66:1009-12
5 Gunduz Z, Yavuz I, Koparal M, Kumankas S, Saraymen R. Serum and cerebrospinal fluid zinc levels in children with febrile convulsions. Acta Pediatr Japoni 1996;38:237-41   DOI
6 Annergers JF, Hauser WA, Elveback LR, Kurland LT. The risk of epilepsy following febrile convulsions. Neurology 1979;29:297-303   DOI
7 al-Eissa YA, al Omair AO, al Herbish AS, al-Jarallah AA, Familusi JB. Antecedents and outcome of simple and complex febrile convulsions among Saudi children. Dev Med Child Neurol 1992;34:1085-90   DOI   ScienceOn
8 Berg AT, Shinnar S. Unprovoked seizures in children with febrile seizures: short-term outcome. Neurology 1996;47:562-68   DOI   ScienceOn
9 Kramer U, Nevo Y, Neufeld MY, Fatal A, Leitner Y, Harel S. Epidemiology of epilepsy in childhood: a cohort of 440 consecutive patients. Pediatr Neurol 1998;18:46-50   DOI   ScienceOn
10 Hamati-Haddad A, Abou-Khalil B. Epilepsy diagnosis and localization in patients with antecedent childhood febrile convulsions. Neurology 1998;50:917-22   DOI   ScienceOn
11 Nelson KB, Elenberg JH. Prognosis in children with febrile seizures. Pediatrics 1978;61:720-27
12 Tsuboi T, Endo S. Febrile convulsions followed by nonfebrile convulsions. A clinical, electroencephalographic and follow-up study. Neuropediatrie 1977;8:209-23   DOI
13 Daniel Sapir, Yael Leitner, Shaul Harel, Uri Kramer. Un-provoked seizures after complex febrile convulsions. Brain and development 2000;2:484-6
14 Park HJ. The influence of low serum sodium levels on the the risk of the recurrence of febrile convulsions. J Korean Child Neurol Soc. 1998;5:265-70
15 Camfield PR, Camfield CS, Gorden K, Dooley JM. Prevention of recurrent febrile seizures. J Pediatr 1995;126:929-30   DOI   ScienceOn
16 Verity CM, Golding J. Risk of epilepsy after febrile convulsions: a national cohort study. Br Med J 1991;303:1373-6   DOI   ScienceOn
17 Maher J, McLachlan RS. Febrile convulsions Is seizure duration the most important predictor of temporal lobe epilepsy. Brain 1995;118:1521-8   DOI   ScienceOn
18 Camfield P, Camfield C, Gordon K, Dooley J. What types of epilepsy are preceded by febrile seizures? A population based study of children. Dev Med Child Neurol 1994;36:887-92   DOI   ScienceOn
19 Lee JS, Park SH, Coe CJ, Kim SH. Pathogenesis and correlations of serum and cerebrospinal fluid zinc levels in febrile convulsions. J Korean Child Neurol Soc. 1999;7:205-13