Browse > Article

A case of childhood relapsing/remitting multiple sclerosis and interferon β-1b treatment in a Korean patient  

Kim, Hyun Seok (Department of Pediatrics, College of Medicine, Sungkyunkwan University Masan Samsung Hospital)
Lee, Won Deok (Department of Pediatrics, College of Medicine, Sungkyunkwan University Masan Samsung Hospital)
Lee, Jun Hwa (Department of Pediatrics, College of Medicine, Sungkyunkwan University Masan Samsung Hospital)
Cho, Kyung Lae (Department of Pediatrics, College of Medicine, Sungkyunkwan University Masan Samsung Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.6, 2007 , pp. 580-584 More about this Journal
Abstract
Multiple sclerosis (MS) is a demyelinating disorder that affects discrete areas of the CNS, including the optic nerves, in a quite variable relapsing-remitting fashion over a prolonged period of time. Although MS is usually considered to be a disease that affects peoples in early to middle adulthood, children do develop multiple sclerosis. The frequency of MS onset before the age of 15 years is 2.7-5% of all cases, while MS onset during infancy and early childhood was observed to be 0.2-0.7% of all cases. We report here on a Korean case of a relapsing-remitting MS female child who was treated with four rounds of intravenous methylpredinsolone pulse therapy and preventive Interferon-$\beta$-1b ($Betaferon^{(R)}$).
Keywords
Multiple Sclerosis; Optic neuritis; Interferon-${\beta}$-1b ($Betaferon^{(R)}$);
Citations & Related Records
연도 인용수 순위
  • Reference
1 Hillert J, Olerup O. Multiple sclerosis is associated with genes within or close to the HLA DR-DQ subregion on a normal DR115, DQ6, DW2 haplotype. Neurology 1993;43: 163-8   DOI
2 Rose AS, Ellison GW, Meyers LW, Tourtellotte WW. Criteria for clinical diagnosis of multiple sclerosis. Neurology 1976;26:20-2   DOI
3 Freedman MS, Thompson EJ, Deisenhammer F, Giovannoni F, Grimsley G, Keir G, et al. Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis. Arch Neurol 2005;62:865-70   DOI   ScienceOn
4 Adams AB, Tyor WR, Holden KR. Interferon beta-1b and childhood multiple sclerosis. Pediatr Neurol 1999;21:481-3   DOI   ScienceOn
5 Ross C, Clemmesen KM, Svenson M, Sorensen PS, Koch-Henriksen N, Skovgaard GL, et al. Immunogenicity of interferon-$\beta$ in multiple sclerosis patients: influence of preparation,dosage, dose frequency and route of administration. Ann Neurol 2000;48:706-12   DOI   ScienceOn
6 Godoth N. Multiple sclerosis in children. Brain Dev 2003;25:229-32   DOI   ScienceOn
7 Lampert PW. Autoimmune and virus induced demyelinating disease. Am J Pathol 1978;91:176-97
8 Poser CM, Party DW, Scheinberg L, Mcdonald WI, Davis FA, Ebers GC, et al. New diagnostic criteria for multiple sclerosis; guidelines for research protocols. Ann Neurol 1983;13:227-31   DOI   ScienceOn
9 Smith ME, Eller NL, McFarland HF, Racke MK, Raine CS. Age depedence of clinical and pathological manifestation of autoimmune demylination. Implications for multiple sclerosis. Am J Pathol 1999;155:1147-61   DOI   ScienceOn
10 McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the Hnternational Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50: 121-7   DOI   ScienceOn
11 Kupersmith MJ, Kaufmann D, Paty DW, Ebers G, Mcfarland H, Johnson K, et al. Megadose corticosteroids in multiple sclerosis. Neurology 1994;44:1-4   DOI   ScienceOn
12 Kesslring J, Miller DH, Robb SA, Kendall BE, Moseley IF, Kingsley D, et al. Acute disseminated encephalomyelitis; MRI findings and distinction from multiple sclerosis. Brain 1990;113:291-302   DOI   ScienceOn
13 Ozakbas S, Idiman E, Baklan B, Yulug B. Childhood and juvenile onset multiple sclerosis: clinical and paraclinical features. Brain Dev 2003;25:233-6   DOI   ScienceOn
14 Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG. Acute disseminated encephalomyelitis and multiple sclerosis in children. Brain 2000;123:2407-22   DOI   ScienceOn
15 Mikaeloff Y, Moreau T, Debouverie M, Pelletier J, Lebrun C, Gout O, et al. Interferon-$\beta$ treatment in paitents with childhood-onset multiple sclerosis. J Pediatr 2001;139:443-6   DOI   ScienceOn
16 Kaye EM, vander Knaop MS. Disorders primarily of white matter. In: Swaiman KF, editor. Pediatric Neurology: principles & practice. 4th ed. Volume 2, Philadelphia: Mosby, 2006:1346-72
17 Barnes MP, Bateman DE, Cleland PG, Dick DJ, Walls TJ, Newman PK, et al. Intravenous methylprednisolone for multiple sclerosis in relapse. J Neurol Neurosurg Psychiatry 1985;48:157-9   DOI