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A case of dapsone syndrome  

Won, Yoo Jong (Department of Pediatrics, School of Medicine, Wonkwang University)
Kim, Ok Lan (Department of Pediatrics, School of Medicine, Wonkwang University)
Yu, Seung Taek (Department of Pediatrics, School of Medicine, Wonkwang University)
Yoon, Young Wook (Department of Pediatrics, School of Medicine, Wonkwang University)
Choi, Du Young (Department of Pediatrics, School of Medicine, Wonkwang University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.5, 2007 , pp. 493-496 More about this Journal
Abstract
Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the initial administration of the drug and results in unpredictable, sometimes fatal outcomes. This report deals with a 13-year-old girl's case with typical features of dapsone syndrome that included fever, exfoliative dermatitis, jaundice, hemolytic anemia and pleural effusion after being treated with dapsone for four weeks.
Keywords
Dapsone syndrome; Hemolytic anemia;
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1 Chiodini P. The chemoprophylaxis of malaria. J Antimicrob Chemother 1987;2:297-302
2 Mills J, Leoung G, Medina I, Hopewell PC, Hughes WT, Wofsy C. Dapsone treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Antimicrob Agents Chemother 1988;32:1057-60   DOI   ScienceOn
3 Prussick R, Shear NH. Dapsone hypersensitivity syndrome. J Am Acad Dermatol 1996;35:346-9   DOI   ScienceOn
4 Lowe J. Treatment of leprosy with diamino-diphenyl sulphone by mouth. Lancet 1950;1:145-50
5 Kumar RH, Kumar MV, Thappa DM. Dapsone syndrome-a five year retrospective analysis. Indian J Lepr 1998;70:271-6
6 Tomecki KJ, Catalano CJ. Dapsone hypersensitivity. The sulfone syndrome revisited. Arch Dermatol 1981;117:38-9   DOI
7 Seoh JK, Bae HK, Yang JS, Choi ED, Lim BK, Kim JS. A Case of Dapsone Syndrome. J Korean Pediatr 1988;31:1376- 80
8 Gruchalla RS. Drug allergy. J Allergy Clin Immunol 2003; 111(2suppl):548-59   DOI   ScienceOn
9 Puri AS, Gupta R, Ghoshal UC, Khan E, Aggarwal R, Naik SR. Hepatic injury in sulfone syndrome: hepatitis or cholestasis? Indian J Gastroenterol 1995;14:20
10 Kim JW, Kim JS. Two Cases of Dapsone Syndrome. Korean J Dermatol 2005;43:655-9
11 Bernstein J, Lorincz A. Sulfonamides and sulfones in dermatologic therapy. Int J Dermatol 1981;20:81-8   DOI
12 Wolf R, Matz H, Orion E, Tuzun B, Tuzun Y. Dapsone: unapproved uses or indications. Clin Dermatol 2000;18:37- 53   DOI   ScienceOn
13 Zuidema J, Hilbers-Modderman ES, Merkus FW. Clinical pharmacokinetics of dapsone. Clin Pharmacokinet 1986;11: 299-315   DOI   ScienceOn
14 Saito S, Ikezawa Z, Miyamoto H, Kim S. A case of the 'dapsone syndrome'. Clin Exp Dermatol 1994;19:152-6   DOI   ScienceOn
15 Choi HW, Song IK, Chung EA, Cha DY, Lim MK, Na DJ, et al. A case of Sulfone syndrome hypersensitivity associated with dapsone. J Asthma Allergy Clin Immunol 2001;21:1206-10
16 Allday EJ, Barnes J. Toxic effects of diaminodiphenylsulphone in the treatment of leprosy. Lancet 1951;2:205-6
17 Ghislain PD, Roujeau JC. Treatment of severe drug reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity syndrome. Dermatol online J 2002; 8:5