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Topiramate can reduce the number of episodic attacks in cyclic vomiting syndrome : a case report  

Yum, Mi-Sun (Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan)
Bae, Keun Wook (Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan)
You, Su Jeong (Department of Pediatrics, Epilepsy Center, College of Medicine, Inje University)
Ko, Tae Sung (Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.4, 2007 , pp. 386-389 More about this Journal
Abstract
Cyclic vomiting syndrome (CVS) is a paroxysmal, recurrent vomiting disorder of unknown pathophysiology and target organ. It has been hypothesized that CVS shares the same mechanism as migraine. We describe here a 5-year-old boy with CVS characterized by episodic vomiting attacks. These recurrent vomiting episodes began at 3 years of age, occurred every month and lasted for 5 days at a time. At the time of admission, no abnormal physical or neurological findings were observed and laboratory findings, including brain MRI and endoscopic examination, revealed nothing specific. The vomiting episodes were self-limited but recurrent and severely interrupted his daily life. When this patient was treated with topiramate, he showed a marked increase of symptom-free periods.
Keywords
Vomiting; Topiramate; Migraine; Child;
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