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Clinical characteristics of acute renal failure of rhabdomyolysis in children  

Kim, Jae Hui (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Goo, Min Ji (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Yeom, Jung Sook (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Park, Eun Sil (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Seo, Ji Hyun (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Lim, Jae Young (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Park, Chan Hoo (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Woo, Hyang Ok (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Youn, Hee Shang (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.3, 2007 , pp. 277-283 More about this Journal
Abstract
Purpose : Acute renal failure (ARF) is an important complication of rhabdomyolysis. The purpose of this study was to identify the major causes of rhabdomyolysis in children and to identify the factors associated with the developmet of ARF. Methods : A retrospective chart review between January 1997 to June 2005 was conducted of 60 patients with a diagnosis of rhabdomyolysis. Rhabdomyolysis was defined by an elevation of serum creatine phosphokinase (CK) greater than 1,000 IU/L with a MM fraction more than 95% or serum myoglobin>300 mg/dL or positive urine myoglobin. Patients were excluded if they had evidence of myocardial ischemia, or cerebrovascular insufficiency. Results : Sixty patients (37 males, 23 females) were enrolled, with the median age of 4.25 year. The most common causes of rhabdomyolysis were repiratory tract infection (9), seizure (7), hypoxia or asphyxia (6). Fifteen patients (25.0%) developed ARF and ten of them (66.0%) died. The initial serum creatinine, uric acid, potassium, pH and peak serum creatinine, initial systolic blood pressure, and mental status were statistically correlated with the development of ARF. The peak serum CK was associated with mortality of rhabdomyolysis. Conclusion : Acute renal failure was significant complication of rhabdomyolysis in children. Several clinical and laboratory factors were statistically associated with the development of ARF and death.
Keywords
Acute renal failure; Rhabdomyolysis; Child;
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