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Clinical characteristics of acute renal failure of rhabdomyolysis in children  

Kim, Jae Hui (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Goo, Min Ji (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Yeom, Jung Sook (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Park, Eun Sil (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Seo, Ji Hyun (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Lim, Jae Young (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Park, Chan Hoo (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Woo, Hyang Ok (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Youn, Hee Shang (Department of Pediatrics, College of Medicine, The Gyeongsang National University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.3, 2007 , pp. 277-283 More about this Journal
Abstract
Purpose : Acute renal failure (ARF) is an important complication of rhabdomyolysis. The purpose of this study was to identify the major causes of rhabdomyolysis in children and to identify the factors associated with the developmet of ARF. Methods : A retrospective chart review between January 1997 to June 2005 was conducted of 60 patients with a diagnosis of rhabdomyolysis. Rhabdomyolysis was defined by an elevation of serum creatine phosphokinase (CK) greater than 1,000 IU/L with a MM fraction more than 95% or serum myoglobin>300 mg/dL or positive urine myoglobin. Patients were excluded if they had evidence of myocardial ischemia, or cerebrovascular insufficiency. Results : Sixty patients (37 males, 23 females) were enrolled, with the median age of 4.25 year. The most common causes of rhabdomyolysis were repiratory tract infection (9), seizure (7), hypoxia or asphyxia (6). Fifteen patients (25.0%) developed ARF and ten of them (66.0%) died. The initial serum creatinine, uric acid, potassium, pH and peak serum creatinine, initial systolic blood pressure, and mental status were statistically correlated with the development of ARF. The peak serum CK was associated with mortality of rhabdomyolysis. Conclusion : Acute renal failure was significant complication of rhabdomyolysis in children. Several clinical and laboratory factors were statistically associated with the development of ARF and death.
Keywords
Acute renal failure; Rhabdomyolysis; Child;
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1 Ward MM. Factors predictive of acute renal failure in rha-bdomyolysis. Arch Intern Med 1998;148:1553-7   DOI
2 Singh D, Chander K, Chopra K. Rhabdomyolysis. Methods Find Exp Clin Pharmachol 2005;27:39-48   DOI   ScienceOn
3 McGoldrick MD. Acute renal failure following trauma. In Anesthesiology Philadelphia: JB Lippincott 1989
4 Proulx F, Fayon M, Farrell CA, Lacroix J, Gauthier M. Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest 1996;109:1033-7   DOI   ScienceOn
5 Dell KM, Schulman SL. Rhabdomyolysis and acute renal failure in a child with influenza A infection. Pediatr Nephrol 1997;11:3635
6 Zager RA. Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 1996;49:314-26   DOI
7 Muckart DJ, Moodley M, Naidu AG, Reddy AD, Meineke KR. Prediction of acure renal failure following soft-tissue injury using the venous bicarbonate concentration. J Trauma 1992;33:813-7   DOI   ScienceOn
8 Gabow PA, Kaenhny WD, Kelleher SP. The spectrum of rhabdomyolysis. Medicine 1982;61:141-52   DOI
9 Fernandez WG, Hung O, Bruno GR, Galea S, Chiang WK. Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis. Am J Emerg Med 2005;23:1-7   DOI   ScienceOn
10 Nakamura C, Yorioka N, Taniguchi Y, Kanahara K, Shinkai Y, Naito Y, et al. Preliminary identification of prognostic factors from clinical outcome in 38 cases of rhabdomyolysis. Clin Exp Nephrol 1998;2:166-70   DOI   ScienceOn
11 Bywaters EG, Beall D. Crush injuries with impairment of renal function. J Am Soc Nephol 1998;9:322-32
12 Watanabe T. Rhabdomyolysis and acute renal failure in children. Pediatr Nephrol 2001;16:1072-5   DOI
13 Holt S, Moore K. Pathogenesis of renal failure in rhabdomyolysis: the role of myoglobin. Exp Nephrol 2000;8:72-6   DOI   ScienceOn
14 Watanabe T, Oda Y. Rhabdomyolysis and acute renal failure in acute necrotizing encephalopathy with influenza A. Pediatr Nephrol 1998;12:85
15 Woodrow G, Brouwnjohn AM, Turney JH. The clinical and biochemical features of acute renal failure due to rhabdomyolysis. Renal Failure 1995;17:467-74   DOI
16 Kang SW, Kim YW, Kim YH. Analysis of nontraumatic rhabdomyolysis during recent 2 years. Korean J Med 2004; 67:467-74