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An epidemiologic study on the seropositive rate of hepatitis A virus among a selected group of children and adults in Busan  

Kwon, Young Ok (Department of Pediatrics, Maryknol Hospital)
Choi, Im Jeong (Department of Pediatrics, Maryknol Hospital)
Jung, Jin Wha (Department of Pediatrics, Maryknol Hospital)
Park, Ji Hyun (Department of Pediatrics, Maryknol Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.3, 2007 , pp. 262-267 More about this Journal
Abstract
Purpose : The prevalence of hepatitis A virus (HAV) in a certain community reflects that community's living standards and hygienic conditions. And the pattern of HAV infection differs over time and geography. Recently, a shift in prevalence has been observed in cases from chilhood to adulthood. We studied the HAV antibody prevalence in the general population in Busan. Methods : From October 2004 to March 2005, total 472 subjects were tested for HAV antibodies. All samples were collected from patients in Maryknol Hospital. Results : The overall seropositive rate was 22.8% (108/472). The seropositive rates were 1.7% in subjects aged 2-5 years, 1.7% in 6-10 years, 0% in 11-20 years, 40.5% in 21-30 years, 82.1% in 31-40 years, 94.7% in 41-50 years, and 100% in subjects aged over 50 years. There was no significant gap between gender groups. Conclusion : As the socioeconomic conditions in Korea have improved, the HAV seropositive rate in school-aged children has dramatically decreased in the last 20 years. But, the seropositive rate of HAV didn't differ according to gender. The seropositive rate of HAV in the pediatric group was very low, which suggests the increasing possibility of clinical HAV infection in adults in the near future. Therefore, we should actively prevent the spread of hepatits A virus. In order to do that, we need to reorganize our lifestyle and personel hygiene and carry out active and passive immunization to high risk groups.
Keywords
Hepatitis A; Seroepidemiologic study;
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1 Stocks J Jr, Neefe JR. The prevention and attenuation of infectious hepatitis by gamma globulin. JAMA 1945;127: 144-5   DOI
2 Fujiyama S, Sasaki Y. Immune serum globulin and its usefulness for prevention of hepatitis A. Nippon Rinsho 2004; 62:496-8
3 Hong WS, Kim JR. A seroepidemiologic study of hepatitis A and B infection in Seoul. Korean J Int Med 1982;25:19-26
4 Lee SD. Asian prospectives on viral hepatitis A. Journal of gastroenterology and hepatology 2000;15:94-9   DOI   ScienceOn
5 Yang DU, Lee YA, Sim JY, Park JY, Jung HL. Park MS, et al. A seroepidemiologic study on hepatitis A in Seoul, Korea. J Korea Pediatr Soc 1999;42:180-5
6 Derya A, Necmi A, Emre A, Akgun Y. Decline of maternal hepatitis a antibody during the first 2 years of life in infants born in Turkey. Am J Trop Med Hyg 2005;73:457-9
7 Feinstone SM, Kapikian AZ, Purcell RH. Hepatitis A; detection by immune electron microscopy of a virus-like antigen associated with acute illness. Science 1973;182:1026-8   DOI   ScienceOn
8 Watson JC, Fleming DW, Borella AJ, Olcott ES, Conrad RE, Baron RC. Vertical transmission of hepatitis A resulting in an outbreak in a neonatal intensive care unit. J Infect Dis 1993;167:567-71   DOI   ScienceOn
9 Rosenblum LS, Villarino ME, Nainan OV. Hepatitis A outbreak in a neonatal intensive care unit; risk factors for transmission and evidence of prolonged viral excretion among preterm infants. J Infect Dis 1991;164:476-82   DOI   ScienceOn
10 Serkan O, Selcen O, Serhan S. Hepatitis A and B seropisivity among medical students. Health Policy 2005;74:39-45   DOI   ScienceOn
11 Locarnini SA, Garland SM, Lehmann NL, Pringle RC, Gist ID. Solid-phase enzyme-linked immunosorbent assay for detection of hepatitis A virus. J Clin Microbiol 1978;8:277-82
12 Decker RH, Overby LR, Ling CM, Frosner G, Deinharder F, Boggs J. Serologic studies of transmission of hepatitis A in humans. J Infect Dis 1979;139:74-82   DOI   ScienceOn
13 Lee CH. Hepatitis vaccination. Program and Abstract, the 48th Annual Fall Meeting of the Korean Association of Internal Medicine; 1996 Oct 25-26; Seoul. Seoul : The Korean Association of Internal Medicine, 1996:82-9
14 Jung PJ, Kim DH, Joo IK, Park CH, Lee WS, Joo YE, et al. Clinical characteristics of sporadic hepatitis A in Gwangju- Jeonnam province. Korean J Hepatol 2005;11:65
15 Provost PJ, Itteson OL, Villarejos VM. A specific complement fixation test for human hepatitis A employing CR 326 virus antigen; diagnosis and epidemiology. Proc Soc Exp Biol Med 1975;149:263-4
16 Melnick JL. History and epidemiology of hepatitis A virus. J Infect Dis 1995;171:2-8   DOI
17 Duval B, De Serres G, Ochnio J, Scheifele D, Gilca V. Nationwide Canadian study of hepatitis A antibody prevalence among children eight to thirteen years old. J Pediatr Infect Dis 2005;24:514-9   DOI   ScienceOn
18 Bradely DW, Maynard JE, Kindman SH. Serodiagnosis of viral hepatitis A; detection of acute phase immunoglobulin M antihepatitis A virus by radioimmunoassay. J Clin Microbiol 1977;5:521-30
19 Korean Society of Pediatrics. Hepatitis A, Guidelines for vaccination, 5th ed. Kwangmoon Co 2002:223-32
20 Provost PJ, Wolanski BS, Muller IVJ, Ittensohn OL, McAleer WJ, Hillman MR. Physical, chemical, and morphological dimensions of human hepatitis A virus strain CR 326(38578). Proc Soc Exp Biol Med 1975;148:532-9
21 Skidmore SJ, Gully PR, Middleton JD, Hassam ZA, Singal GM. An outbreak of hepatitis A on a hospital ward. J Med Virol 1985;17:175-7   DOI   ScienceOn
22 Jung PJ, Kim DH, Joo IK, Park CH, Lee WS, Joo YE, et al. Clinical characteristics of sporadic hepatitis A in Gwangju- Jeonnam province. Korea J Hepatol 2005;11:65
23 McMahon BJ, Williams J, Bulkow L. Immunogenecity of and inactivated hepatitis A vaccine in Alaska native children and native and non-native adults. J Infect Dis 1995;171: 676-9   DOI   ScienceOn
24 Kim H, Kim JH, Kim DH, Heo JK, Lee WB, Seo BK, et al. Epidemiologic changes and clinical features of hepatitis A in children; living in Kyung-gi province, since 1988 to 1998. Korea J Pediatr Infect Dis 1998;5:230-6
25 Choi JW, Lee KI, Lee DZ, Han JH, Hang SS, Lee KS. Outbreak of hepatitis A in Taejon in 1996; clinical and epidemiologic study in children. Korean J Int Med 1997;4: 90-6
26 De Silvestri A, Avanzini MA, Terulla V, Zucca S, Polatti F, Belloni C. Decline of maternal hepatitis A virus antibody levels in infants. Acta Paediatr 2002;91:882-4   DOI
27 Purcell RH, Wong DC, Moritizu Y, Dienstag JL, Routenberg JA, Boggs JD. A microtiter solid-phase radioimmunoassay for hepatitis antigen and antibody. J Immunol 1976;116:349-56
28 Clemens R, Safary A, Hepburn A, Roche C, Stanbury WJ, Andre FE. Clinical experience with an inactivated hepatitis A vaccine. J Infect Dis 1995;171:44-9   DOI
29 Van Damme P, Banatvala J, Fay O. Hepatitis A booster vaccination: is there a need? Lancet 2003;362:1065-71   DOI   ScienceOn
30 Im DS, Jo KH, Kim HC. A epidemiologic study of hepatitis A in the northwest area of Jeonbuk, Korea 1989. Korea J Internal Medicine 1992;43:57-63
31 Winokur PL, Stepleton JT. Immunoglobulin prophylaxis for hepatitis A. Clin Infect Dis 1992;14:580-6   DOI   ScienceOn
32 Aszkenasy OM. A community outbreak of hepatitis A in a religious community in Indiana: failure of immune serum globulin to prevent the spread of infection. Epidemiol Infect. 2000;124:309-13   DOI   ScienceOn
33 Chodick G, Ashkenazi S, Aloni H, Peled T, Lerman Y. Hepatitis A virus seropositivity among hospital and community healthcare workers in Israel:the role of occupation, demography and socioeconomic background. J Hosp Infect 2003; 54:135-40   DOI   ScienceOn
34 Zachoval R, Kroener M, Deinharlt F. Serology and interferone production in patient with acute hepatitis A. J Infect Dis 1990;161:353-4
35 Ashur Y, Adler R, Rowe M, Shouval D. Comparison of immunogenicity of two hepatitis A vaccines-VAQTA and HAVRIX-in young adults. Vaccine 1999;17:2290-6   DOI   ScienceOn