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Carotid artery intima media thickness in obese children : relation with cardiovascular risk factors  

Lee, Jin (Department of Pediatrics, College of Medicine, Korea University)
Kwon, Hyo Jin (Department of Pediatrics, College of Medicine, Korea University)
Park, Moon Ho (Department of Neurology, College of Medicine, Korea University)
Jang, Ki Young (Department of Pediatrics, College of Medicine, Korea University)
Lee, Kee-Hyoung (Department of Pediatrics, College of Medicine, Korea University)
Lee, Kwang Chul (Department of Pediatrics, College of Medicine, Korea University)
Son, Chang Sung (Department of Pediatrics, College of Medicine, Korea University)
Lee, Joo Won (Department of Pediatrics, College of Medicine, Korea University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.11, 2007 , pp. 1091-1096 More about this Journal
Abstract
Purpose : The of common carotid artery intima media thickness (IMT) is an acknowledged noninvasive marker for early atherosclerotic changes. We investigate whether common carotid IMT is different between obese and normal-weight children and also evaluate the relationships IMT with cardiovascular risk factors. Methods : We collected the clinical data (age, sex, pubertal stage, body mass index) and measured blood pressure, glucose, insulin, lipid profiles and adiponectin in 49 obese children (mean age, 12 years) and 24 nonobese children as controls. The control group was composed of 24 nonobese children of the same age, sex and pubertal stage. We measured the carotid IMT of all subjects by B-mode ultrasound with a 7.5-MHz linear transducer and analyzed. Results : Obese children demonstrated a significantly thicker intima media (mean, 0.34 mm, peak, 0.42 mm) compared to the control group (mean, 0.31 mm, peak, 0.38 mm, P<0.01). IMT was significantly correlated to the BMI (r=0.431, P<0.01), age (r=0.317, P<0.01), total cholesterol (r=0.377, P< 0.01), triglyceride (r=0.253, P<0.05) and low-density lipoprotein cholesterol (r=0.289, P<0.05). Serum adiponectin was significantly lower in obese children than in controls (11.2 ng/mL vs. 14.7 ng/mL, P<0.05) and negatively related with IMT (r=-0.267, P<0.05). Conclusion : Obesity is associated with increased carotid artery IMT in children. Our results suggest vascular changes in obesity seem to occur already in childhood and vascular ultrasonography may helpful for screening cardiovascular complications in obese children.
Keywords
Aterial intima; Obesity; Child; Adiponectin;
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1 Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WHo Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med 1992;327:1350-5   DOI   ScienceOn
2 Wofford JL, Kahl FR, Howard GR, McKinney WM, Toole JF, Crouse JR, 3rd. Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioscler Thromb 1991;11;1786-94
3 Wong GW, Wang J, Hug C, Tsao TS, Lodish HF. A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci USA 2004;101:10302-7   DOI   ScienceOn
4 Park KO, Choi SJ, Yeom HH, Chung S, Yu JJ, Park Y, et al. Carotid intima-media thickness measurement in obese children. Korean J Pediatr 2005;48:935-8
5 Woo KS, Chook P, Yu CW, Sung RY, Qiao M, Leung SS, et al. Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation 2004;109:1981-6   DOI   ScienceOn
6 Reinehr T, Kiess W, de Sousa G, Stoffel-Wagner B, Wunsch R. Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006;55:113-8   DOI   ScienceOn
7 American Academy of Pediatrics. Committee on Nutrition. Cholesterol in childhood. Pediatrics 1998;101:141-7   DOI
8 Cho YL, Kim DJ, Kim HD, Choi SH, Kim SK, Kim HJ, et 31. Reference values of carotid artery intima-media thickness and association with atherosclerotic risk factors in healthy subjects in Korea. Korean J Med 2003;64:275-83
9 Jarvisalo MJ, Raitakari M, Toikka JO, Putto-Laurila A, Rontu R, Laine S, et al. Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes. Circulation 2004;109:1750-5   DOI   ScienceOn
10 Tounian P, Aggoun Y, Dubern B, Varille V, Guy-Grand B, Sidi D, et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 2001;358:1400-4   DOI   ScienceOn
11 Zhu W, Huang X, He J, Li M, Neubauer H. Arterial intima-media thickening and endothelial dysfunction in obese Chinese children. Eur J Pediatr 2005;164:337-44   DOI
12 Shimada K, Miyazaki T, Daida H. Adiponectin and atherosclerotic disease. Clin Chim Acta 2004;344:1-12   DOI   ScienceOn
13 Gnasso A, Irace C, Mattioli PL, Pujia A. Carotid intimamedia thickness and coronary heart disease risk factors. Atherosclerosis 1996;119:7-15   DOI   ScienceOn
14 Berenson GS, Srinivasan SR, Bao W, Newman WP, 3rd, Tracy RE, Wattigney W A. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998;338:1650-6   DOI   ScienceOn
15 Freedman DS, Dietz WH, Tang R, Mensah GA, Bond MG, Urbina EM, et al. The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2004;28:15966
16 Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al. Adiponectin, an adipocvte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000;102:1296-301   DOI   ScienceOn
17 Tonstad S, Joakimsen O, Stensland-Bugge E, Leren TP, Ose L, Russell D, et al. Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. Arterioscler Thromb Vasc BioI 1996;16:984-91   DOI   ScienceOn
18 Iannuzzi A, Licenziati MR, Acampora C, Salvatore V, Auriemma L, Romano ML, et al. Increased carotid intimamedia thickness and stiffness in obese children. Diabetes Care 2004;27:2506-8   DOI   ScienceOn
19 Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-5   DOI   ScienceOn
20 Lebuffe G, Boullier A, Tailleux A, Delfly B, Dupuis B, Fruchart JC, et al. Endothelial derived vasorelaxation is impaired in human APO A-I transgenic rabbits. Biochem Biophys Res Commun 1997;241:205-11
21 Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002;20:159-69   DOI   ScienceOn
22 Lavrencic A, Kosmina B, Keber I, Videcnik V, Keber D. Carotid intima-media thickness in young patients with familial hypercholesterolaemia. Heart 1996;76:321-5   DOI
23 Hurwitz Eller N, Netterstrom B. The intima media thickness and coronary risk factors. Int Angiol 2001;20:118-25
24 Markus RA, Mack WJ, Azen SP, Hodis HN. Influence of lifestyle modification on atherosclerotic progression determined by ultrasonographic change in the common carotid intima-media thickness. Am J Clin Nutr 1997;65:1000-4   DOI
25 Kim YJ, Shim YH, Yoo JH, Lee K, Hong YM. Measurement of the common carotid artery by ultrasound as a predictor of atherosclerosis in obese adolescents. Korean J Pediatr 2005;48:745-52
26 Davis PH, Dawson JD, Riley W A, Lauer RM. Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine Study. Circulation 2001;104:2815-9   DOI   ScienceOn
27 Gunnell DJ, Frankel SJ, Nanchahal K, Peters TJ, Davey Smith G. Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort. Am J Clin Nutr 1998;67:1111-8   DOI
28 Park YS, Lee DH, Choi JM, Kang YJ, Kim CH. Trend of obesity in school age children in Seoul over the past 23 years. Korean J Pediatr 2004;47:247-57