Browse > Article

The myocarditis and cardiomyopathy in children  

Kil, Hong Ryang (Department of Pediatrics, Chugnanm National University, College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.11, 2007 , pp. 1049-1054 More about this Journal
Abstract
Myocarditis represent an important condition encountered by general pediatricians & general practitioners. Its presentation is varied, and therefore a high index of suspicion must be maintained when the possibility of myocarditis is raised. A progression from viral myocarditis to dilated cardiomyopathy has long been hypothesized. Treatment is initially aimed at achieving hemodynamic stability and is largely supportive. There is currently little evidence to support the immunomodulatory or specific antiviral therapies. Pediatric cardiomyopathies are a heterogeneous group of disorders with diverse genetic, infectious, mitochodrial and metabolic etiologies. The timing and severity of presentation vary according to cardiomyopathy type as well as genetic and ethnic factors. The behavior of specific cardiomyopathies can be predicted by morphological and functional attributes, as well as underlying patient characteristics.
Keywords
Myocarditis; Cardiomyopathy; Treatment; Children;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wojnicz R, Nowalany-Kozielska E, Wodniecki J. SzczurekKatanski S, Nozynski J, Zembala M, et al. Immunohistological diagnosis of myocarditis: potential role of sarcolemmal induction of the MHC and ICAM-1 in the detection of autoimmune mediated myocyte injury. Eur Heart J 1998;19:156472
2 Bowles NE, Ni J, Kearney DL, Pauschinger M, Schultheiss HP, McCarthy R, et al. Detection of viruses in myocardial tissues by polymerase chain reaction: evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 2003;42:466-72   DOI   ScienceOn
3 Panhoweit S, Lamparter S, Schoppet M, Maisch B. Parvo virus B19 genome in endomyocardial biopsy specimens. Circulation 2004;109:e179   DOI
4 Mason JW, O' Connell JB, Herskowitz A, Rose NR, McManus BM, Billingham ME, et al. For the Myocarditis Treatment Trial Investigators. A clinical trial of immunosuppressive therapy for myocarditis. N Engl J Med 1995; 333:269-75   DOI   ScienceOn
5 Dec GW, Palacios IF, Fallon JT, Aretz HT, MillsJ, Lee DC, et al. Active myocarditis in the spectrum of acute dilated cardiomyopathies: clinical features, histologic correlates, and clinical outcome. N Engl J Med 1985;312:885-90   DOI   ScienceOn
6 Dec GW, Waldman H, Southern J, Fallon JT, Hutter AM, Palacios I. Viral myocarditis mimicking acute myocardial infarction. J Am Coll Cardiol 1992;20:85-9   DOI
7 Sarda L, Colin P, Boccara F, Daou D, Lebtahi R, Faraggi M, et al. Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms. J Am Coll Cardiol 2001;37:786-92   DOI   ScienceOn
8 McCarthy RE, Boehmer JP, Hruban RH, Hutchins GM, Kasper EK, Hare JM, et al. Long-term outcome of fulminant myocarditis as compared with acute (non-fulminant) myocarditis. N Engl J Med 2000;342:690-5   DOI   ScienceOn
9 Grogan M, Redfield MM, Bailey KR, Reeder GS, Gersh RJ, Edwards WD, et al. Long-term outcome of patients with biopsy-proved myocarditis: comparison with idiopathic di1ated cardiomyopathy. J Am Coll Cardiol 1995;26:80-4   DOI   ScienceOn
10 Parrillo JE, Cunnion RE, Epstein SE, Parker MM, Saffredini AF, Brenner M, et al. A prospective, randomized, controlled trial of prednisone for dilated cardiomyopathy. N Engl J Med 1989;321:1061-68   DOI   ScienceOn
11 Miric M, Vasiljevic J, Bojic M, Popovic Z, Keserovic N, Pesic M. Long-term follow up of patients with dilated heart muscle disease treated with human leucocytic interferon alpha or thymic hormones: initial results. Heart 1996;75:596-601   DOI
12 Towbin JA, Lowe AM, Colan SD, Sleeper LA, Orav EJ, Clunie S, et al. Incidence, cause, and outcomes of dilated cardiomyopathy in children. JAMA 2006;296:1867-76   DOI   ScienceOn
13 Lieberman EB, Hutchins GM, Herskowitz A, Rose NR, Baughman KL. Clinicopathologic description of myocarditis. J Am Coll Cardiol 1991;18:1617-26   DOI
14 Pollick C. Muscular sub aortic stenosis: hemodynamic and clinical improvement after disopyramide. N Engl J Med 1982;307:997-9   DOI   ScienceOn
15 Magnani JW, Dec W. Myocarditis-current trends in diagnosis and treatment. Circulation 2006;113:876-90   DOI   ScienceOn
16 Lieback E, Hardouin I, Meyer R, Bellach J. Hetzer R. Clinical value of echo cardiographic tissue characterization in the diagnosis of myocarditis. Eur Heart J 1996;17:135-42   DOI   ScienceOn
17 Pulerwitz TC, Cappola TP, Felker GM, Hare JM, Baughman KL, Kasper EK. Mortality in primary and secondary myocarditis. Am Heart J 2004;147:746-50   DOI   ScienceOn
18 Weintraub RG, Nugent AW, Daubeney PE. Pediatric cardiomyopathy: The Australian experience. Progress in Pediatric cardiology 2007;23:17-24   DOI   ScienceOn
19 Dec GW, Palacios I, Yasuda T, Fallon JT, Khaw BA, Strauss HW, et al. Antimyosin antibody cardiac imaging: its role in the diagnosis of myocarditis. J Am Coll Cardiol 1990;16:97-104   DOI
20 Lipshultz SE, Sleeper LA, Towbin JA. The incidence of pediatric cardiomyopathy in two regions of the United States. N Engl J Med 2003;348:1647-55   DOI   ScienceOn
21 Shanes JG, Ghali J, Billingham ME, Ferrans VJ, Fenoglio JJ, Edwards WD, et al. Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 1987;75:401-5   DOI   ScienceOn
22 Schulte HD, Borisov K, Gams E, Gramsch-Zabel H, Losse B, Schwartzkopff B. Management of symptomatic hypertrophic obstructive cardiomyopathy-long-term results after surgical therapy. Thorac Cardiovasc Surg 1999;47:213-8   DOI   ScienceOn
23 Arola A, Jokinen E, Ruuskanen O. Epidemiology of idiopathic cardiomyopathies in children and adolescents: a nationwide study in Finland. Am J Epidemiol 1997;146:385-93   DOI   ScienceOn
24 Pauschinger M, Bowles NE, Fuentes-Garcia FJ, Pham V, Kuhl U, Schwimmbeck PL, et al. Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. Circulation 1999;99:1348-54   DOI   ScienceOn
25 Baboonian C, Treasure T. Meta-analysis of the association of enteroviruses with human heart disease. Heart 1997;78:539-43
26 Braunwald E, Seidman CE, Sigwart U. Contemporary evaluation and management of hypertrophic cardiomyopathy. Circulation 2002;106:1312-6   DOI   ScienceOn
27 Liu PP, Mason JW, Advances in the understanding of myocarditis. Circulation 2001;104:1076-82   DOI   ScienceOn
28 Why HJ, Meany BT, Richardson PJ, Olsen EG, Bowles NE, Cunningham L, et al. Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy. Circulation 1994;89:2582-9   DOI   ScienceOn
29 Webb JG, Butany J, Langer G, Scott G, Liu PP. Myocarditis and myocardial hemorrhage associated with thrombotic thrombocytopenic purpura. Arch Intern Med 1990;150:1535-7   DOI
30 Triska AE, Trinkaus K, Chen SC. Improved outcomes of pediatric dilated cardiomyopathy with utilization of heart transplantation. J Am Coll Cardiol 2004;44:391-7   DOI   ScienceOn
31 Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. ACC/ AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). Circulation 2005;112:1825-52   DOI   ScienceOn
32 Doolan A, Langlois N, Semsarian C. Causes of sudden cardiac death in young Australians. Med J Aust 2004;180: 110-2
33 Cassling RS, Linder J, Sears TD, Waller BF, RogIer WC, Wilson JE, et al. Quantitative evaluation of inflammation in biopsy specimens from idiopathically failing or irritable hearts: experience in 80 pediatric and adult patients. Am Heart J 1985;110:713-20   DOI   ScienceOn
34 Nugent A W, Daubeney PEF, Chondros. The epidemiology of childhood cardiomyopathy in Australia. N Engl J Med 2003;348:1639-46   DOI   ScienceOn
35 Grogan M, Redfield MM, Bailey KR, Reeder GS, Gersh RJ, Edwards WD, et al. Long-term outcome of patients with biopsy-proved myocarditis: comparison with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 1995;26:80-4   DOI   ScienceOn
36 McNamara DM, Holubkov R, Starling RC, Dec GW, Loh E, Torre- Amione G, et al. Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy. Circulation 2001;103:2254-59   DOI   ScienceOn
37 Cooper LT, Berry GJ, Shabetai R. For the Multicenter Giant Cell Myocarditis Study Group Investigators. Idiopathic giantcell myocarditis: natural history and treatment. N Engl J Med 1997;336:1860-6   DOI   ScienceOn
38 Kawai C. From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future. Circulation 1999;99:1091-100.   DOI   ScienceOn
39 Feldman AM, McNamara D. Myocarditis. N Engl J Med 2000;343:1388-98   DOI   ScienceOn
40 Hofman P, Drici MD, Gibelin P, Michiels JF, Thyss A. Prevalence of toxoplasma myocarditis in patients with the acquired immunodeficiency syndrome. Br Heart J 1993;70: 376-81   DOI