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Normal antistreptolysin O titers of children by age group in the Gyeonggi-Incheon region  

Lee, Jihun (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Kim, Yoo Jung (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Bin, Joong Hyun (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Hwang, Ja Young (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Hahn, Seong Hoon (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Kim, So Young (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Kim, Hyun Hee (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Lee, Wonbae (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.10, 2007 , pp. 965-969 More about this Journal
Abstract
Purpose : Measurement of antistreptolysin O (ASO) is often necessary to confirm a clinical diagnosis of recent streptococcal infection, especially in patients suspected of rheumatic fever and acute glomerulonephritis. Standard normal ranges for ASO should be established locally for each age group. We analyzed ASO to determine the upper limit of normal (ULN) ASO in children in the Gyeonggi-Incheon area. Methods : ASO in normal individual concentrations were measured quantitatively by nephelometry on sera from 753 children (Male : 381, Female : 372). ULN were determined by separating the upper 20% from the lower 80% of the group (80 percentile). Results : The mean ASO concentration calculated in a total cases was $149.9{\pm}7.2IU/mL$. The ASO concentration in neonates was $83.4{\pm}10.7IU/mL$, and lowest in the 1 year of age group, $26.7{\pm}6.6IU/mL$, and increased to $318.0{\pm}33.2IU/mL$ gradually in the 9 years of age group. Thereafter, ASO concentration decreased. The ULN for neonates was 122 IU/mL, for 0-3 years, 40 IU/mL; for 4-6 years, 113 IU/ mL; for 7-9 years, 489 IU/mL; for 10-19 years, 433 IU/mL; for 20-29 years, 122 IU/mL. Conclusion : The age-specific ULN for children in the Gyeonggi-Incheon area were determined. The distribution of ASO concentration according to age groups was different from previous reports. These results should be of clinical value to physicians to interprete the ASO results of their patients.
Keywords
Antistreptolysin O; Pediatrics; Reference Values;
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