Browse > Article

Type 2 diabetes mellitus and metabolic syndrome  

Hwang, Jin Soon (Department of Pediatrics, Ajou University School of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.49, no.7, 2006 , pp. 710-717 More about this Journal
Abstract
Type 2 diabetes mellitus in children and adolescents has been increasing for last 10 years. The increase in frequency of type 2 diabetes appears to parallel the increase in prevalence and severity of obesity in children and adolescents. The metabolic syndrome, cluster of potent risk factors for atherosclerotic cardiovascular disease and type 2 diabetes, consists of insulin resistance, obesity, hypertension and hyperlipidemia. The atherosclerotic cardiovascular disease are rarely seen in the young, but the pathologic processes and risk factors are associated its development have been shown to begin during childhood. In pediatrician it is important to recognize early and treat aggressively for prevention of future cardiovascular disease in children and adolescents with metabolic syndrome.
Keywords
Type 2 diabetes mellitus; Metabolic syndrome; Obesity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607   DOI   ScienceOn
2 American Diabetes Association. Type 2 diabetes in children and adolescents. Pediatrics 2000;105:671-80   DOI   ScienceOn
3 Kaufman FR. Type 2 diabetes mellitus in children and youth : a new epidemic. J Pediatr Endocrinol Metab 2002; 15:737-44
4 Ronnemaa T, Koskenvuo M, Marniemi J, Kolvunen T, Sajantila A, Rissanen A, et al. Glucose metabolism in identical twins discordant for obesity : the critical role of visceral fat. J Clin Endocrinol Metab 1997;82:383-7   DOI
5 Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346:802-10   DOI   ScienceOn
6 McGill H, McMahan CA, Deteminants of atherosclerosis in the young; pathobiological determinants of atherosclerosis in youth(PDAY) research group. Am J Cardiol 1998;82: 30T-6T
7 American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care 2000;23:381-9   DOI   ScienceOn
8 Meigs JB. Epidemiology of cardiovascular complications in type 2 diabetes mellitus. Acta Diabetol 2003;40(Suppl 2): S358-61   DOI
9 Hardin DS, Hebert JD, Bayden T, Dehart M, Mazur L. Treatment of childhood syndrome X. Pediatrics 1997;100:e5
10 Raustrop A, Pangrazi RP, Stahle A. Physical activity level and body mass index among schoolchildren in south-eastern Sweden. Acta Paediatr 2004;93:400-4   DOI
11 Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics 2001;107:e55   DOI   ScienceOn
12 Berenson GS, Bao W, Srinivasan SR. Abnormal characteristics in young offspring of parents with non-insulindependent diabetes mellitus. The Bogalusa Heart Study. Am J Epidemiol 1996;144:962-7   DOI   ScienceOn
13 Zieske AW, Malcom GT, Strong JP. Natural history and risk factors of atherosclerosis in children and youth : the PDAY study. Pediatr Pathol Mol 2002;21:213-37   DOI
14 Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC, et al. UKPDS 26 : sulfonylurea failure in non-insulin dependent diabetic patients over six years. Diabet Med 1998;15:297-303   DOI   ScienceOn
15 Csabi G, Torok K, Jeges S, Molnar D. Presence of metabolic cardiovascular syndrome in obese children. Eur J Pediatr 2000;159:91-7   DOI
16 Chatelain P. Children born with intra-uterine growth retardation( IUGR) or small for gestational age(SGA) : long term growth and metabolic consequences. Endocr Regul 2000; 34:33-6
17 Vanhala M, Vanhala P, Kumpusalo E, Halonen P, Takala J. Relation between obesity from childhood to adulthood and the metabolic syndrome: population based study. Br Med J 1998;317:319   DOI   ScienceOn
18 Morales PA, Mitchell BD, Valdez RA, Hazuda HP, Stern MP, Haffner SM. Incidence of NIDDM and impaired glucose tolerance in hypertensive subjects. The San Antonio Heart Study. Diabetes 1993;42:154-61   DOI   ScienceOn
19 Steinberger J, Moorehead C, Katch V, Rocchini AP. Relationship between insulin resistance and abnormal lipid profile in obese adolescents. J Pediatr 1995;126:690-5   DOI   ScienceOn
20 Valente AM, Strong W, Sinaiko A. Obesity and insulin resistance in young people. Am Heart J 2001;142:440-4   DOI   ScienceOn
21 Goran MI, Ball GDC, Cruz ML. Cardiovascular endocrinology 2; obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. J Clin Endocrinol Metab 2003;88:1417-27   DOI
22 Cook S, Weitzman M, Auinger MS, Nguyen M, Dietz WH. Prevalence of metabolic syndrome phenotype in adolescents. Arch Pediatr Adolesc Med 2003;157:821-7   DOI   ScienceOn
23 Harrell JS, Gansky SA, McMurray RG, Bungdiwala SI, Frauman AC, Bradley CB. School-based interventions improve health in children with multiple cardiovascular risk factors. Pediatrics 1998;102:371-80   DOI   ScienceOn
24 Glaser B, Cerasi E. Early intensive insulin treatment for induction of long-term glycaemic control in type 2 diabetes. Diabetes Obes Metab 1999;1:67-74   DOI   ScienceOn
25 Yngve A, Sjostrom M. Breastfeeding in countries of the European Union and EFTA : current and proposed recommendations, rationale, prevalence, duration and trends. Public Health Nutr 2001;4:631-45
26 Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin dependent diabetes mellitus among adolescents. J Pediatr 1996;128:608-15   DOI   ScienceOn
27 Berenson GS. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease : the Bogalusa Heart Study. Am J Cardiol 2002;90:3L-7L   DOI   ScienceOn
28 Bitsori M, Kafatos A. Dysmetaolic syndrome in childhood and adolescence. Acta Paediatr 2005;94:995-1005   DOI
29 Bacha F, Saad R, Gungor N, Janosky J, Arslanian SA. Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents : race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab 2003;88:233-40
30 Gungor N, Arslanian S. Progressive beta cell failure in type 2 diabetes mellitus of youth. J Pediatr 2004;144:656-9   DOI   ScienceOn
31 Ogden Cl, Flegal KM, Caroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002;288:1728-32   DOI
32 Haffner SM, Valdez RA, Hazuda HP, Michell BD, Morales PA, Stern MP. Prospective analysis of the insulin resistance syndrome(syndrome x). Diabetes 1992;41:715-22   DOI   ScienceOn
33 Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001;345:790-7   DOI   ScienceOn
34 The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993: 329:977-86   DOI   ScienceOn
35 Gungor N, Bacha F, Saad R, Janosky J, Arslanian S, et al. Youth type 2 diabetes : insulin resistance, beta-cell failure, or both? Diabetes Care 2005;28:638-44   DOI   ScienceOn
36 Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, et al. Type 2 diabetes among North American children and adolescents; an epidemiologic review and a public health perspective. J Pediatr 2000;136: 664-72   DOI   ScienceOn
37 American Diabetes Association. Management of dyslipidemia in children and adolescents with diabetes. Diabetes Cared 2003;26:2194-7   DOI   ScienceOn
38 Hales CN, Barker Dj, Clark PM, Cox LJ, Fall C, Osmond C, et al. Fetal and infant growth and impaired glucose tolerance at age 64. Br Med J 1991;303:1019-22   DOI
39 Hattersley AT, Tooke JE. The fetal insulin hypothesis : an alternative explanation of the association of low birth weight with diabetes and cardiovascular disease. Lancet 2002;359:46-7   DOI   ScienceOn
40 Bao W, Srinivasan SR, Valdez R, Greenlund KJ, Wattigney WA, Berenson GS. Longitudinal changes in cardiovascular risk from childhood to young adulthood in offspring of parents with coronary artery disease : the Bogalusa Heart Study. JAMA 1997;278:1749-54   DOI
41 Reaven GM, Lithell H, Landberg L. Hypertension and associated metabolic abnormalities-the role of insulin resistance and the sympathoadrenal system. New Engl J Med 1996; 334:374-81   DOI   ScienceOn
42 Defronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 2000;133:73-4   DOI   ScienceOn
43 Das UN. Obesity, metabolic syndrome X, and inflammation. Nutrition 2002;18:430-2   DOI   ScienceOn
44 Webber LS, Srinivasan SR, Wattigney WA, Berenson GS. Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study. Am J Epidemiol 1991;133:884-99   DOI
45 Steinberger J, Daniels SR. Obesity, Insulin resistance, diabetes, and cardiovascular risk in children : an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee( Council on Cardiovascular Disease in the Young) and the Diabetes Committee(Council on Nutrition, Physical Activity, and Metabolism). Circulation 2003;107:1448-53   DOI   ScienceOn
46 Krebs NF, Jacobson MS, American Academy of Pediatrics Committee on Nutrition. Prevention of pediatric overweight and obesity. Pediatrics 2003;112:424-30   DOI   ScienceOn
47 Sondike SB, Copperman N, Jacobson MS. Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents. J Pediatr 2003;142: 253-8   DOI   ScienceOn
48 Hollander P. The case for tight control in diabetes. Postgrad Med 1984;75:80-7   DOI
49 Rosenbloom Al, Joe JR, Young RS, Winter WE, et al. Emerging epidemic of type 2 diabetes in youth. Diabetes Care 1999;22:345-54   DOI   ScienceOn
50 Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403   DOI   ScienceOn
51 Kavey RE, Daniels SR, Lauer RM, Atkins DL, Hayman LL, Taubert K, et al. American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. J Pediatr 2003;142: 368-72   DOI   ScienceOn
52 Khaw KT, Wareham N, Luben R, Bingham S, Oakes S, Welch A, et al. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European prospective investigation of cancer and nutrition(EPIC-Norfolk). BMJ 2001;322:15-8   DOI
53 Gil-Campos M, Canete RR, Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 2004;23: 963-74   DOI   ScienceOn
54 Jones KL, Arslanian S, Peterokova VA, Park JS, Tomlinson MJ, et al. Effect of metformin in pediatric patients with type 2 diabetes : a randomized controlled trial. Diabetes Care 2005;25:89-94   과학기술학회마을   DOI
55 Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome(syndrome X) in young adulthood. The Bogalusa Heart Study. Diabetes 2002;51:204-9   DOI   ScienceOn
56 Fagot-Campagna A, Knowler WC, Pettitt DJ. Type 2 diabetes in Pima Indian children : cardiovascular risk factors at diagnosis and 10 years later [abstract]. Diabetes 1998;47 (Suppl l):A155   DOI
57 Liese AD, Mayer-Davis EJ, Haffner SM. Development of the multiple metabolic syndrome : an epidemiologic perspective. Epidemiol Rev 1998;20:157-72   DOI   ScienceOn
58 Stinivasan SR, Elkasabani A, Dalferes ER Jr, Bao W, Berenson GS. Characteristics of young offspring of type 2 diabetic parents in a biracial(black-white) community-based sample : the Bogalusa Heart Study. Metabolism 1998;47: 998-1004   DOI   ScienceOn
59 McTerman Cl, McTerman PG, Harte AL, Levick PL, Barnett A, Kumar S. Resistin, central obesity, and type 2 diabetes. Lancet 2002;359:46-7   DOI   ScienceOn
60 Yokoyama H, Okudaira M, Otani T, Takaike H, Miura J, Saeki A, et al. Existence of early-onset NIDDM Japanese demonstrating severe diabetic complications. Diabetes Care 1997;20:844-7   DOI   ScienceOn
61 Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997;337:869-73   DOI   ScienceOn
62 Scott C, Smith J, Cradock M, Pihoker C. Characteristics of youth-onset non-insulin dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics 1997;100:84-91   DOI   ScienceOn
63 Despres JP. The insulin resistance-dyslipidemia syndrome : the most prevalent cause of coronary artery disease- Can Med Assoc J 1993;148:1339-40
64 Yokoyama H, Okudaira M, Otani T, Watanabe C, Takaike H, Miura J, et al. High incidence of diabetic nephropathy in earlyonset Japanese NIDDM patients : risk analysis. Diabetes Care 1998;21:1080-5   DOI   ScienceOn
65 Mayer EJ, Newman B, Austin Ma, Zhang D, Quesenberry CP Jr, Edwards K, et al. Genetic and environmental influences on insulin levels and the insulin resistance syndrome : an analysis of women twins. Am J Epidemiol 1996; 143:323-32   DOI   ScienceOn
66 Epstein LH, Wing RR, Penner BC, Kress MJ. Effect of diet and controlled exercise on weight loss in obese children. J Pediatr 1985;107:358-61   DOI
67 Kay JP, Alemzadeh R, Langley G, D'Angelo L, Smith P, Holshouser S. Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metabolism 2001;50: 1457-61   DOI   ScienceOn
68 Travers SH, Jeffers BW, Bloch CA, Hill JO, Eckel RH. Gender and Tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab 1995;80:172-8   DOI
69 Kishida K, Nagaretani H, Kondo H, Kobayashi H, Tanaka S, Maeda N, et al. Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochem Biophys Res Commun 2003;306:286-92   DOI   ScienceOn
70 Srinivasan SR, Frontoni MG, Berenson GS. Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes; the Bogalusa Heart Study. Metabolism 2003;52-443-50   DOI
71 Odeleye OE, de Courten M, Pettitt DJ, Ravussin E. Fastion hyperinsulinemia is a predictor of increased body weight gain and obesity in pima Indian children. Diabetes 1997; 46:1311-45
72 Martin BC, Warram JH, Rosner B, Rich SS, Soeldner JS, Krolewski AS. Familial clustering of insulin sensitivity. Diabetes 1992;41:850-4   DOI   ScienceOn
73 Din JN, Newby DE, Flapan AD. Omega 3 fatty acids and cardiovascular disease-fishing for a natural treatment. Br Med J 2004;328:30-5   DOI   ScienceOn
74 Guo SS, Wu W, Chumlea WC, Roche AF. Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr 2002; 76:653-8   DOI
75 Maki KC. Dietary factors in the prevention of diabetes mellitus and coronary artery disease associated with the metabolic syndrome. Am J Cardiol 2004;S93:12-7
76 Chen W, Srinivasan SR, Elkasabany A, Berenson GS. Cardiovascular risk factors clustering features of insulin resistance syndrome(syndrome X) in a biracial(black-white) population of children, adolescents, and young adults : the Bogalusa Heart Study. Am J Epidemiol 1999;150:667-74   DOI   ScienceOn
77 Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344: 1343-50   DOI   ScienceOn
78 Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. N Engl J Med 1998;338:1650-6   DOI   ScienceOn
79 Robinson T. Reducing children's television viewing to prevent obesity : a randomised controlled trial. JAMA 1999;282: 1561-7   DOI   ScienceOn
80 Falkner B, Hassink S, Ross J, Gidding S. Dysmetabolic syndrome : multiple risk factors for premature adult disease in an adolescent girl. Pediatrics 2002;110:e1-5   DOI   ScienceOn
81 Ng MC, So WY, Lam VK, Cockram CS, Bell GI, Cox NJ, et al. Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21- q25. Diabetes 2004;53:2676-83   DOI   ScienceOn
82 Barker DJP, Gluckman PD, Godrey KM, Harding J, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease. Lancet 1993;341:938-41   DOI   ScienceOn