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Genotype of rotavirus isolated from patients with rotaviral enteritis and neurological complications  

Choi, Jae Hyung (Department of Pediatrics, Hospital of Han Yang University)
Kim, Jeong-Mi (Department of Pediatrics, Hospital of Han Yang University)
Kim, Yong Joo (Department of Pediatrics, Hospital of Han Yang University)
Oh, Jae Won (Department of Pediatrics, Hospital of Han Yang University)
Kim, Chang Lyul (Department of Pediatrics, Hospital of Han Yang University)
Yum, Myung Kul (Department of Pediatrics, Hospital of Han Yang University)
Sul, In Joon (Department of Pediatrics, Hospital of Han Yang University)
Kang, Jung Oak (Department of Laboratory Medicine, Hospital of Han Yang University)
Publication Information
Clinical and Experimental Pediatrics / v.49, no.5, 2006 , pp. 513-518 More about this Journal
Abstract
Purpose : This study was undertaken to determine the differences in genotypes of rotavirus and their incidence between patients with acute rotaviral enteritis who suffered neurologic complications and those who did not suffer neurologic complications. Methods : Among the 82 patients with rotaviral enteritis whose genotype was analyzed, 71 patients were not associated with neurologic complications(neurology(-) group), and eleven patients were associated with neurologic complications(neurology(+) group). Four G genotypes and four P genotypes were determined by reverse trans cription and multiplex polymerase chain reaction. Results : In the neurology(-) group, the number of G4, G3, G2 and G1 was 24(35.3 percent), 23 (33.8 percent), 17(25.0 percent) and 4(5.6 percent), respectively and the number of P6, P4, P8 and P9 was 26(36.1 percent), 23(31.9 percent), 22(30.6 percent) and 1(1.4 percent), respectively. G2P4, and G4P6 were the most frequently found com bination genotypes, respectively. In the neurology(+) group, the number of G2, G3 and G4 was 9(75.0 percent), 2(16.7 percent) and 1(8.3 percent), respectively and the number of P4, P6, P8 and P9 was 8(66.7 percent), 2(16.7 percent), 1(8.3 percent) and 1(8.3 percent), respectively. G2P4 was the most frequently found combination genotype. The incidence of each of the G2, P4 and G2P4 was significantly higher in the neurology(+) group when compared to that of each of the G2, P4, and G2P4 in the neurology(-) group. Conclusion : In the patients with acute rotavirus gastroenteritis associated with neurologic complications, the G1 genotype was not found and genotypes of the G2, P4, and G2P4 were more frequently found.
Keywords
Rotavirus; G type; P type; Seizure; Encephalopathy; Neurologic abnormality;
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