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Risk factors and clinical characteristics of necrotizing enterocolitis in full-term newborns  

Jeoung, Young Mi (Department of Pediatrics, Il Sin Christian Hospital)
Je, Hyun Gon (Department of Pediatrics, Il Sin Christian Hospital)
Son, Sang Hee (Department of Pediatrics, Il Sin Christian Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.49, no.5, 2006 , pp. 489-493 More about this Journal
Abstract
Purpose : The purpose of this study was to determine those factors which could contribute to the development of necrotizing enterocolitis(NEC) in fullterm. Methods : We retrospectively reviewed the medical record of 20 full-terms with NEC(${\geq}$modified Bell's staging criteria IIa) who were admitted to the Neonatal Intensive Care Unit of Il Sin Christian hospital from January 1998 through July 2005, and for each case, the next 2 healthy newborns were matched as controls. Results : Mean gestational age and birth weight in the fullterm with NEC group was 38.42 weeks and 2,915 g; in the healthy fullterm without NEC group, it was 38.61 weeks and 3,148 g. When compared with the control group, NEC infants had a significantly higher frequency of chorioamnionitis, protracted diarrhea. As for Apgar score at 1 min <7, respiratory problem, congenital heart disease. there were no differences in frequency of preeclampsia, maternal diabetes, maternal drug abuse, meconium-stained amniotic fluid, polycythemia or exchange transfusion. Conclusion : Most of these full term infants have a predisposing factor before developing NEC. Our study suggested that NEC in fullterm infants was significantly associated with protracted diarrhea, and congenital heart disease.
Keywords
Necrotizing enterocolitis; Full-term newborn;
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1 Choi JH, Shim SY, Jung KE, Kim ES, Lee JA, Kim EK, et al. Clinical charicteristics and predisposing factors in full-term and preterm neonates with necrotizing enterocolitis. Korean J Pediatr 2005;12:79-86
2 Walsh MC, Kilegman RM. Necrotizing enterocolitis : treatment based on staging criteria. Pediatr Clin North Am 1986;33:179-201   DOI
3 Book LS, Herbst JJ, Jung AL. Comparison of fast-and slow-feeding rate schedules to the development of necrotizing enterocolitis. J Pediatr 1976;89:463-6   DOI
4 Lucey JF. Colonic perforation after exchange transfusion. N Engl J Med 1969;282:724
5 Super M. Enterocolitis following exchange transfusion. Lancet 1971;2:1203-4
6 Michael C. Necrotizing enterocolitis. In : Richard JM, Avery AF, Mjchele CW, editors. Neonatal perinatal medicine. 8th ed. Philadelphia : ST Mosby Co, 2005:1403-17
7 Wilson SE, Wodley MM. Primary necrotizing enterocolitis in infants. J Pediatr 1976;88:1026-31   DOI
8 Engum SA, Grosfeld JL. Necrotizing enterocolitis. Curr Opin Pediatr 1998;10:123-30   DOI
9 Peter CS, Feuerhahn M, Bohnhorst B, Schlaud M, Ziesing S, von der Hardt H, et al. Necrotizing enterocolitis : is there a relationship to specific pathogen? Eur J Pediar 1999;158: 67-70   DOI
10 Ng SCY. Necrotizing enterocolitis in the fullterm neonate. Pediatr Child Health 2001;37:1-4
11 Friedman AB, Abellera RM, Lidsky I, Lubert M. Perforation of the colon after exchange transfusion in the twoborn. N EngI J Med 1970;282:796-7   DOI   ScienceOn
12 Kliegman RM. Neonatal necrotizing enterocolitis : implications for an infectous disease. Pediatr Clin North Am 1979;26:327-44   DOI
13 Mizrahi A, Barlow O, Berdon W, Blanc WA, Silnerman WA. Necrotizing enterocolitis in premature infant. J Pediatr 1965;66:679-706
14 Polin RA, Pollack PF, Barlow B, Wigger HJ, Slovis TL, Santuli TV. Necrotizing enterocolitis in term infants. J Pediatr 1976;89:460-2   DOI
15 Bolisetty S, Lui K, Oei J, Wojulewia J. A regional study of underlying congenital diseases in term neonate with necrotizing entercolitis. Acta Paediatr 2000;89:1226-30   DOI
16 McElhinney DB, Hedric HL, Bush DM, Pereira GR, Stafford PW, Gaynor JW, et al. Necrotizing enterocolitis in neonates with congenital heart disease : risk factors and outcomes. J Pediatr 2000;106:1080-7   DOI   ScienceOn
17 McKeown RE, Marsh TD, Amarnath U, Garrison CZ, Addy CL, Thompson SJ. Role of delayed feeding and of feeding increments in necrotizing enterocolitis. J Pediatr 1992;121: 764-70   DOI
18 Emilia M, Nelson C, Eduardo B. Necrotizing enterocolitis in fullterm or near-term infant : risk factors. Biol Neonate 1997;71:292-8   DOI   ScienceOn
19 Dunn L, Halman S, Weiner J, Kijegman R. Beneficial effects of early hypocaloric enteral feeding on neonatal gastrointestinal function : preliminary report of a randomized trial. J Pediatr 1988;112:622-9   DOI
20 Hartmen GZ, Boyajian MJ, Choi SS, Eichelberger MR, Newman KD, Powell DM, et al. General surgery. In : Avery GB, Fletcher MA, MacDonald MG, editors. Neonatology. pathophysiology and management of the newborn. 5th ed. Philadelphia : Lippncot Williams & Wilkins. 1999;158:1030-2
21 Choi JH, Yun CK. Clinical observation on necrotizing enterocolitis. J Korean Pediatr Soc 1985;28:423-33
22 Barbara N. Part 1. Currrent controversies in the understanding of necrotizing enterocolitis. Adv Neonatal Care 2003;3:107-20   DOI   ScienceOn
23 Caplan MS, Mackendrick W. Inflammatory mediators and intestinal injury. Clin Perinatol 1994;21:235-46   DOI
24 Caplan MS, Jilling T. New concepts in necrotizing enterocolitis. Curr Opin Pediatr 2001;13:111-5   DOI   ScienceOn
25 Kosloske AM. Pathogenesis and prevention of necrotizing enterocolitis, a hypothesis based on personel observation and review of literature. J Pediatr 1984;74:1086-92
26 Joshi VV, Dryer DA, Batesk RD. Neonatal necrotizing enterocolitis. occurrence secondary to thrombosis of abdominal aorta following umbilical arterial catheterization. Arch Pathol 1975;99:540-3
27 Kamitsuka MD, Horton MK, Wiliams MA. The incidence of necrotizing enterocolitis after introducing standardized feeding schedules for infants between 1,250 g and 2,500 g and less than 35 weeks of gestation. Pediartics 2000;105: 379-84
28 Overturf GD, Marcy MSS. Focal bacterial infection. In : Remington JS, Klein JO, editors. Infectious diseases of the fetus and newborn infants. 5th ed. Philadelphia : WB saunders Co, 2001;1058-63
29 Llyod JR. The etiology of gastro-intestinal perforations in the newborn. J Pediatr Surg 1969;4:77-84   DOI   ScienceOn
30 Martinez TE, Claure N, Bancalari E. Necrotizing enterocolitis in full-term or near-term infants : risk factors. Biol Neonate 1997;71:292-8   DOI   ScienceOn
31 Santulli TV, Schullinger JN, Heird WC, Gongaware RD, Wigger J, Bariow B, et al. Acute necrotizing enterocolitis in infancy, review 64 cases. J Pediatr 1975;55:6-87
32 Touloukian RJ, Posch JN, Spencer R. The pathogenesis of ischemic gastroenterocolitis of the neonate : selective gut mucosal ischemia in asphyxiated neonatal piglet. J Pediatr Surg 1972;7:194-201   DOI   ScienceOn