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Steroid and enalapril therapy - possible cause of toxic epidermal necrolysis  

Kim, Dong Wook (Department of Pediatrics, Sanggye Paik Hospital, Inje University, College of Medicine)
Jung, Da Eun (Department of Pediatrics, Sanggye Paik Hospital, Inje University, College of Medicine)
Koo, Ja Wook (Department of Pediatrics, Sanggye Paik Hospital, Inje University, College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.49, no.3, 2006 , pp. 332-336 More about this Journal
Abstract
Toxic epidermal necrolysis (TEN) is a rare, acute and life-threatening cutaneous drug reaction. TEN is characterized by the sudden onset of extensive necrosis in the epidermis and frequent mucous membrane involvement. The pathogenesis has not yet been elucidated. In addition, no particular treatment for TEN has been established. We report a case of TEN in a 14-year-old-boy, which might have been caused by steroids with enalapril treatment for membranous nephropathy. He recovered after intravenous immunoglobulin therapy.
Keywords
Steroid; Enalapril; Toxic epidermal necrolysis; Intravenous immunoglobulin;
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