Browse > Article

Cause of enteroviral infection in children in chungnam area summer, 2005  

Jeon, Se Yun (Department of Pediatrics College of Medicine, Soonchunhyang University)
Choi, Suk Joo (Department of Pediatrics College of Medicine, Soonchunhyang University)
Kim, Yong Bae (Department of preventive medicine, Soonchunhyang University)
Nam, Hae Seon (Department of clinical parasitology, Soonchunhyang University)
Park, Kwi Sung (Chungcheongnam-Do Health and Environment Research Institute)
Baek, Kyung Ah (Chungcheongnam-Do Health and Environment Research Institute)
Park, Joon Soo (Department of Pediatrics College of Medicine, Soonchunhyang University)
Publication Information
Clinical and Experimental Pediatrics / v.49, no.11, 2006 , pp. 1186-1193 More about this Journal
Abstract
Purpose : Enterovirus infection is a type of viral infection that occurs relatively frequently in children during summer. It has clinical symptoms of non-specific fever, aseptic encephalomeningitis, gastrointestinal diseases, skin rash and, hand-foot-mouth disease. However, it can also occcaisionally, result in fatal symptoms like myocarditis, epicardial inflammation, transverse myelitis, quadriplegia and etc. There have been epidemic enterovirus studies, but not in the Chungnam area. Therefore, we undertook this study in order to comprehend the cause viruses in this area. Methods: We enlisted 157 children hospitalized with enteroviral infections at Soonchunhyang University hospital in Cheonan between May and August 2005. Cerebrospinal fluids or feces were collected during the acute phase after hospitalization, and observed the cytopathic effects caused by enterovirus and using reverse transcription polymerase chain reaction (RT-PCR). Results : The number of children hospitalized due to possible enteroviral infection during the period of study was 157. The number of children who tested positive with the reverse transcription polymerase chain reaction totalled 32 cases (20.4 percent). Among the children with entroviral diseases, 20 were male and 12 were female, thus the sex ratio of male to female was 1.67:1. Their clinical symptoms included fever most frequently (93.7 percent), was followed by headaches (90.0 percent), meningeal irritation signs (65.0 percent), and abdominal pain (30.0 percent). As for the type of isolated enterovirus, there were 17 cases of echovirus 18 and 6 cases of coxsackievirus B5. Furthermore, there were 2 cases of echovirus 9, 1 case of coxsackievirus A6 and coxsackievirus B3, respectively. But 5 cases were not determined by genotype. Conclusion : Echovirus 18 is circulating in Korea. We reported on identified enteroviruses, including echovirus 18, using RT-PCR in the Chungnam area during the summer of 2005.
Keywords
Enterovirus; Echoviruses; Children; Reverse transcription polymerase chain reaction;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Oberste MS, Nix WA, Maher K, Pallansch MA. Improved molecular identification of enteroviruses by RT-PCR and amplicon sequencing. J Clin Virol 2003;26:375-7   DOI   ScienceOn
2 Van Biervliet S, De Waele K, Van Winckel M, Robberecht E. Transient exocrine pancreatic insufficiency as a possible complication of an enterovirus infection. Eur J Pediatr 2003;162:872-4   DOI   ScienceOn
3 Rotbart HA. Diagnosis of enteroviral meningitis with the polymerase chain reaction. J Pediatr 1990;117:85-9   DOI
4 Cho JY, Kim HJ, Jung GY, Pang JK, Lee DB. Epidemic asepic meningitis in 1993. J Korean Pediatr Soc 1995;38:901-6
5 Andersson P, Edman K, Lindberg AM. Molecular analysis of the echovirus 18 prototype: evidence of interserotypic recombination with echovirus 9. Virus Res 2002;85:71-83   DOI   ScienceOn
6 Wilfert CM, Lauer BA, Cohen M, Costenbader ML, Myers E. An epidemic of echovirus 18 meningitis. J Infect Dis 1975;131:75-8   DOI   ScienceOn
7 Shah SS, Gallagher PG. Neonatal sepsis due to echovirus 18 infection. J Perinat Med 1997;25:381-4   DOI   ScienceOn
8 Feigin RD, Cherry JD, Demmler GJ, Kaplan SL. Enteroviruses and Parechoviruses In : Cherry JD, editor. Textbook of pediatric infectious disease. 5th ed. Philadelphia : Saunders 2004;1984-2041
9 Ishimaru Y, Nakano S, Yamaoka K, Takami S. Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system. Arch Dis Child 1980;55:583-8   DOI
10 Miyamura K, Yamashita K, Yamadera S, Kato N, Akatsuka M, Yamazaki S. An epidemic of echovirus 18 in 1988 in Japan high association with clinical manifestation of exanthem. A report of the National Epidemiological Surveillance of Infectious Agents in Japan. Jpn J Med Sci Biol 1990;43:51-8   DOI
11 Behrman RE, Kliegman RM, Jenson HB. Nonpolio enteroviruses In : Abzug MJ. Nelson textbook of pediatrics. 17th ed. Philadelphia : Saunders 2004;1042-8
12 Chumakov M, Voroshilova M, Shindarov L, Lavrova I, Gracheva L, Koroleva G, et al. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch Virol 1979;60:329-40   DOI
13 Drake JW. Rates of spontaneous mutation among RNA viruses. Proc Natl Acad Sci USA 1993;90:4171-5
14 Thoelen I, Moes E, Lemey P, Mostmans S, Wollants E, Lindberg AM, et al. Analysis of the serotype and genotype correlation of VP1 and the 5' noncoding region in an epidemiological survey of the human enterovirus B species. J Clin Microbiol. 2004;42:963-71   DOI   ScienceOn
15 Rotbart HA, Sawyer MH, Fast S, Lewinski C, Murphy N, Keyser EF, et al. Diagnosis of enteroviral meningitis by using PCR with a colorimetric microwell detection assay. J Clin Microbiol 1994;32:2590-2
16 Simoes EA, Sarnow P. An RNA hairpin at the extreme 5' end of the poliovirus RNA genome modulates viral translation in human cells. J Virol. 1991;65:913-21
17 Schlesinger Y, Sawyer MH, Storch GA. Enteroviral meningitis in infancy: potential role for polymerase chain reaction in patient management. Pediatrics 1994;94:157-62
18 Sawyer MH. Enterovirus infections: diagnosis and treatment. Semin Pediatr Infect Dis 2002;13:40-7   DOI   ScienceOn
19 Park SY, Kwon OS, Kim WY, Jung WJ, Ma SH, Kim SK, et al. Epidemics of aseptic meningitis in kyoungsangnamdo from march to October, 1997. Korean J Pediatr Infect Dis 1998;5:104-14
20 Abebe A., Johansson B., Abens J., Strannegard O. Detection of enteroviruses in faeces by polymerase chain reaction. Scand J Infect Dis 1992;24:265-73   DOI
21 Guney C, Ozkaya E, Yapar M, Gumus I, Kubar A, Doganci L. Laboratory diagnosis of enteroviral infections of the central nervous system by using a nested RT-polymerase chain reaction (PCR) assay. Diagn Microbiol Infect Dis 2003;47:557-62   DOI   ScienceOn
22 Wee JS, Lee Sk, Seon KJ. Paralytic disease related to enterovirus 71 infection. J Korean Acad Rehab Med 1999;23:1046-51
23 Park JS, Kim MR, Kim DH, Park CY, Lee KH, Lee HR, et al. Epidemiologic and clinical features of enteroviral infections in children; 1996-1998. Korean J Pediatr Infect Dis 1999;6:210-8
24 Miwa C, Watanabe Y. Epidemic of aseptic meningitis with echovirus type 18 in Gifu Prefecture in 1988. Kansenshogaku Zasshi 1990;64:815-21
25 Johansson ME, Holmstrom S, Abebe A, Jacobsson B, Ekman G, Samuelson A, et al. Intrauterine fetal death due to echovirus 11. Scand J Infect Dis 1992;24:381-5   DOI
26 Roivainen M. Enteroviruses: new findings on the role of enteroviruses in type 1 diabetes. Int J Biochem Cell Biol 2006;38:721-5   DOI   ScienceOn
27 Schlesinger Y, Sawyer MH, Storch GA. Enteroviral meningitis in infancy: potential role for polymerase chain reaction in patient management. Pediatrics 1994;94:157-62
28 Ehrenfeld E, Semler BL. Anatomy of the poliovirus internal ribosome entry site. Curr Top Microbiol Immunol. 1995;203: 65-83
29 Cho KS, Jung MJ. Outbreak pattern of isolated enterovirus causing aseptic meningitis in busan, 2002 years. Korea J Microbiol Biotechnol 2004;32:179-83
30 Cheon DS, Lee J, Lee K, Lee S, Park K, Ahn J, et al. Isolation and molecular identification of echovirus 13 isolated from patients of aseptic meningitis in Korea, 2002. J Med Virol 2004;73:439-42   DOI   ScienceOn
31 Chung JA, Kim YJ, Choi HJ, Chung WK. An epidemic of aseptic meningitis in summer 1996 and global analysis and comparison of it with 1993. J Korean Pediatr Soc 1997;40:1081-90
32 Takahashi S, Miyamoto A, Oki J, Azuma H, Okuno A. Acute transverse myelitis caused by echovirus type 18 infection. Eur J Pediatr 1995;54:378-80
33 Roivainen M. Enteroviruses: new findings on the role of enteroviruses in type 1 diabetes. Int J Biochem Cell Biol 2006;38:721-5   DOI   ScienceOn