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Clinical Effects of Oseltamivir in Children with Influenza in Busan, in the First Half of 2004  

Park, Soo Kyoung (Department of Pediatrics, Maryknoll Hospital)
Choi, So Young (Department of Pediatrics, Maryknoll Hospital)
Kim, Sung Mi (Department of Pediatrics, Maryknoll Hospital)
Kim, Gil Heun (Department of Pediatrics, Maryknoll Hospital)
Jung, Jin Hwa (Department of Pediatrics, Maryknoll Hospital)
Choi, Im Jung (Department of Pediatrics, Maryknoll Hospital)
Cho, Kyung Soon (Institute of Health & Environment, Busan)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.9, 2005 , pp. 976-985 More about this Journal
Abstract
Purpose : Although influenza is one of the most important causes of acute respiratory tract infections in children, effective antiviral therapies are not common and there are only a few clinical studies on treatment of influenza in children. We evaluated the efficacy of oseltamivir in the treatment of naturally aquired influenza in children during the first half of 2004 in Busan. Methods : From January 2004 to June 2004, throat swabs and nasal washes were performed and cultured for the isolation of influenza virus and tested by rapid antigen detection test(QuickVue influenza test) in children with suspected influenza infections. The children who responded positively to the QuickVue influenza test, we divided into two groups : an oseltamivir treatment group and a control group. We compared their clinical symptoms(including fever duration) and diagnosis. The medical records of patients with influenza virus infection were reviewed retrospectively. Results : A total of 621 individuals were suspected of influenza infection. Influenza viruses were isolated in 79(17.2 percent) out of 621 patients examined. QuickVue influenza tests were positive in 181 cases. The treatment group(83 individuals) received oseltamivir twice daily for 5 days, and the control group(99 individuals) were administered only symptom relief medicine. There was no differences between the two groups in clinical diagnosis and symptoms. Oseltamivir treatment reduced the fever duration and other respiratory symptoms. There were no adverse events associated with oseltamivir treatment. Conclusion : Our data suggest that oral oseltamivir treatment reduces the fever duration and other respiratory symptoms of acute influenza without side effects in children.
Keywords
Influenza; Children; Antigen; Test; Oseltamivir;
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1 Treanor JJ, Hayden FG, Vrooman PS, Barbarash R, Bettis R, Riff D, et al. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza : a randomized, controlled trial. JAMA 2000;283:1016-24   DOI   PUBMED   ScienceOn
2 Nicholson KG, Aoki FY, Ostelhaus ADME, Trottier S, Carexicz O, Mercier H, et al. Efficacy and safety of oseltamivir in treatment of acute influenza : a randomized, controlled trial. Lancet 2000;355:1845-50   DOI   ScienceOn
3 Centers for Disease Control and Prevention. Prevention and control of influenza : recommendations of the Advisory Committee on Immunization Practices(ACIP). MMWR 1998; 48:1-28
4 Hyden FG, Osterhaus ADME, Treanor JJ, Felming DM, Aoki FY, Nicholson KG, et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. N Engl J Med 1997;337:874-80   DOI   ScienceOn
5 MIST. Randomized trial of efficiacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections. N Engl J Med 1998;352:1877-81
6 Poehling KA, Griffin MR, Daoust G, Rubin E, McDonal J. QuickVue influenza test for the rapid detection of influenza A and B viruses in a pediatric population. Clin Diagn Lab Immunol 2002;9:925-6
7 Yamazaki M, Mitamura K, Kimura K. Clinical evaluation of an immunochromatography test for rapid diagnosis of influenza. Kansenshogaku Zasshi 2001;75:1047-53
8 Uyeki TM. Influenza diagnosis and treatment in children : a review of studies on clinically useful tests and antiviral treatment for influenza. Pediatr Infect Dis J 2003;22:164-77
9 Lee PY, Matchar DB, Clements D, Huber J, Hamilton JD, Peterson ED. Economic analysis of influenza vaccination and antiviral treatment for healthy working adults. Ann Intern Med 2002;137:225-31   DOI   ScienceOn
10 Muennig PA, Khan K. Cost-effectiveness of vaccination versus treatment of influenza in healthy adolescents and adults. Clin Infect Dis 2001;33:1879-85   DOI   ScienceOn
11 Mitamura K, Sugaqa N, Nirasawa M, Shinjoh M, Takeuchi Y. Effectiveness of oseltamivir treatment against influenza type A and type B infection in children. Kansenshogaku Zasshi 2002;76:946-52
12 Oo C, Barrett J, Hill G, Mann J, Dorr A, Dutkowski R, et al. Pharmacokinetics and dosage recommendations for an oseltamivir oral suspension for the treatment of influenza in children. Pediatr Drugs 2001;3:229-30   DOI   ScienceOn
13 Kiso M, Mitamura K, Sakai-Tagawa Y, Shiraishi K, Kawakami C, Kimura K, et al. Resistant influenza A viruses in children treated with oseltamivir : descriptive study. Lancet 2004;364:759-65   DOI   ScienceOn
14 Mcclellan K, Perry CM. Oseltamivir : A review of its use in influenza. Drugs 2001;61:263-83   DOI   ScienceOn
15 Hayden FG, Atmar RL, Schilling M, Johnson C. Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza. N Engl J Med 1999;341:1336-43   DOI   ScienceOn
16 Hayden FG, Belshe RM, Clover RD, May AJ, Oakes MG, Soo W. Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. N Engl J Med 1989;321:1696-702.   DOI   ScienceOn
17 Hayden FG, Gwaltney JM Jr, Van de Castle RL, Adams KF, Giodani B. Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrob Agents Chemother 1981;19:226-33   DOI   ScienceOn
18 Glezen WP. Influenza and hospitalizations in children. N Engl J Med 2000;342:1752-3   DOI   ScienceOn
19 Smith KJ, Roberts MS. Cost-effectiveness of newer treatment strategies for influenza. Am J Med 2002;113:300-7   DOI   ScienceOn
20 Kawai N. Iwaki N, Kawashima T, Satoh I, Tsuchimoto T, Shigematsu T, et al. Effectiveness of oseltamivir on influenza and influencing factors : age of patients, type of influenza virus and timing of initial administration. Kansenshogaku Zasshi 2003;77:428-9
21 Rothberg MB, Bellantonio S, Rose DN. Management of influenza in adults older than 65 years of age : cost effectiveness of rapid testing and antiviral therapy. Ann Intern Med 2003;139:321-9
22 Quach C, Newby D, Daoust G, Rubin E, McDonald J. QuickVue influenza test for rapid detection of influenza A and B viruses in a pediatric population. Clin Diagn Lab Immunol 2002;9:925-6
23 Kashiwagi S. Criteria for the use of antiinfluenza agent. Nippon Rinsho 2003;61:1963-6
24 Simonsen L, Fukuda K. The impact of influenza on hospitalization. J Infect Dis 2000;181:831-7   DOI   ScienceOn
25 Vtakova T, Nermut MV, Hay AJ. The NB protein is an integral component of the membrane of influenza B virus. J Gen Virol 1996;77:1689-94
26 Kawakami C, Shimizu H, Watanabe S. Evaluation of immunochromatography method for rapid detection of influenza A and B viruses in Japanese. Kansenshogaku Zasshi 2001;75:792-9
27 Lin JT, Yu XZ, Cui DJ, Chen XY, Zhu JH, Wang YZ, et al. A multicenter randomized controlled study of the efficacy and safety of oseltamivir in the treatment of influenza in a high risk population. Zhonghua Jie He He Hu Xi Za Zhi 2004;27:455-9
28 Hall CB, Dolin R, Gala CL. Children with influenza A infection : treatment with rimantadine. Pediatrics 1987;80:275-82
29 Doller G, Tjhen KY, Schuy W, Gerth HJ. Rapid diagnosis of influenza virus infections from nasopharyngeal secretions. Monatsschr Kinderheilkd 1991;139:287-91
30 Bettes R, Mandell GL, Bennet J, Dolin R. Principles and practice of infectious disease. 4th ed. New York : Churchill Livingstone Inc. 1995:1546-67
31 Choi YH. Prevention and treatment of influenza. J Korean Med Assoc 2002;45:1487-95
32 Carr J, Ives J, Kelly L, Lambkin R, Oxford J, Mendel D, et al. Influenza virus carrying neuraminidase with reduced sensitivity to oseltamivir carboxylate has altered properties in vitro and is compromised for infectivity and replicative ability in vivo. Antivir Res 2002;54:79-88   DOI   ScienceOn
33 Couch RB. Prevention and treatment of influenza. N Engl J Med 2000;343:1778-87   DOI   ScienceOn
34 Wrigh P, Behrman RE, Kliegman RM, Jenson HB. Nelson textbook of pediatrics. 16th ed. philadelphia : WB Saunders Co, 2000:987-90
35 Englund JA. Antiviral therapy of influenza. Semin Pediatr Infect Dis 2002;13:120-8   DOI   ScienceOn
36 Schmidt AC. Antiviral therapy for influenza : a clinical and economic comparative review. Drugs 2004;64:2031-46   DOI   PUBMED   ScienceOn
37 Aoki FY. Early administration of oral oseltamivir increases the benefits of influenza treatment. J Antimicrob Chemother 2003;51:123-9   DOI   ScienceOn
38 Wang MZ, Tai CY, Mendel DB. Mechanism by which mutations at His 274 alter sensitivity of influenza A virus N1 neuraminidase to oseltamivir carboxylate and zanamivir. Antimicrob Agents Chemother 2002;46:3809-16   DOI   ScienceOn