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Pulmonary Function Test and Body Composition Analysis in Obese Children  

Shin, Jee Seon (Department of Pediatrics, College of Medicine, Ewha Womans University)
Park, Ji Hye (Department of Pediatrics, College of Medicine, Ewha Womans University)
Kim, Ji Young (Department of Pediatrics, College of Medicine, Ewha Womans University)
Kim, Su Jung (Department of Pediatrics, College of Medicine, Ewha Womans University)
Hong, Young Mi (Department of Pediatrics, College of Medicine, Ewha Womans University)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.6, 2005 , pp. 588-593 More about this Journal
Abstract
Purpose : Obesity is associated with disturbances of ventilatory functions in adults. But few studies have evaluated the pulmonary complications of obesity in the pediatric population. The purpose of this study is to clarify the effects of obesity on pulmonary function and body composition in obese children. Methods : Forty seven obese children whose ages ranged from nine to twelve years were evaluated for their body composition(intracellular fluid, extracellular fluid, protein mass, mineral mass, soft lean mass, fat mass, percent body fat, fat distribution) by bioelectrical impedance analysis. Hemoglobin, serum glucose, aspartate aminotransferase(AST), alanine aminotransferase(ALT), total cholesterol and triglycerides were measured. Pulmonary function test was performed by spirometer. Results : Intracellular fluid, protein mass, fat mass, percent body fat and fat distribution were significantly higher in severely obese children with an obesity index of more than 150 percent compared with those with an index of less than 150 percent. Peak expiratory flow rate(PEFR) was significantly lower in severely obese children with obesity index of more than 150 percent compared with those with less than 150 percent($241.7{\pm}14.6L/sec$ vs $276.8{\pm}64.3L/sec$). PEFR, forced expiratory flow 25 percent($FEF_{25}$), mid expiratory flow rate(MEFR), forced expiratory flow 50 percent($FEF_{50}$), forced expiratory volume in 1st second($FEV_1$) and forced vital capacity(FVC) were decreased in 37.0 percent, 14.8 percent, 14.8 percent, 11.1 percent, 3.7 percent and 3.7 percent of obese children, respectively. Conclusion : PEFR was significantly decreased in obese children. Pulmonary function test must be performed in severely obese children and more extended study is needed in other age groups.
Keywords
Obesity; Pulmonary function test; Body composition;
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1 Carey IM, Cook DG, Strachan DP. The effects of adiposity and weight change on forced expiratory volume decline in a longitudinal study of adults. Int J Obese Relat Metab Disord 1999;23:979-85   DOI   ScienceOn
2 Svendsen OL, Hassager C, Bergmann I, Christiansen C. Measurement of abdominal and intra-abdominal fat in postmenopausal women by dual energy X-ray absorptiometry and anthropometry : comparision with computerized tomography. Int J Obes Relat Metab Disord 1993;17:45-51
3 Schoenberg JB, Beck CJ, Bouhuys A. Growth and decay of pulmonary function in healthy blacks and whites. Respir Physiol 1978;33:367-93   DOI   ScienceOn
4 Gonen B, O'Donnell P, Post TJ, Quinn TJ, Schulman ES. Very low lipoproteins(VLDL) trigger the release of histamine from human basophils. Biochim Biophys Acta 1987; 917:418-24   DOI   ScienceOn
5 Marcus CL, Curtis S, Koerner CB, Joffe A, Serwint JR, Loughlin GM. Evaluation of pulmonary function and polysomnography in obese children and adolescents. Pediatr Pulmonol 1996;21:176-83   DOI   ScienceOn
6 De Lorenzo A, Maiolo C, Mohamed EI, Andreoli A, Petrone-De Luca P, Rossi P. Body composition analysis and changes in airways function in obese adults after hypocaloric diet. Chest 2001;119:1409-15   DOI   ScienceOn
7 Lazarus R, Sparrow D, Weiss ST. Effect of obesity and fat distribution on ventilation function : the normative aging study. Chest 1997;11:891-8
8 Lazarus R, Colditz G, Berkey CS, Speizer FE. Effects of body fat on ventilatory function in children and adolescents: Cross-sectional findings from a random population sample of school children. Pediatr Pulmonol 1997;24:187-94   DOI   ScienceOn
9 Hyatt RE, Schilder DP, Fry DL. Relationship between maximum expiratory flow and degree of lung inflation. J Appl Physio 1958;13:331-6
10 Ferretti A, Giampiccolo P, Cavalli A, Milic-Emili J, Tantucci C. Expiratory flow limitation and orthopnea in massively obese subjects. Chest 2001;119:1401-8   DOI   ScienceOn
11 Kushiner RF, Schoeller DA. Estimation of total body water by bioelectrical impedance analysis. Am J Clin Nutr 1986; 44:417-24
12 Lee DH, Lee C, Lee CG, Hwang YS, Cha SH, Choi Y. The incidence of complication in severely obese children. J Korean Pediatr Soc 1991;34:445-53
13 Gaensler EA. Clinical pulmonary physiology. N Engl J Med 1995;252:177-84   DOI   ScienceOn
14 Lee JE, Park KW, Cho SJ, Whang IT, Hong YM. Body composition by bioelectrical impedance analysis in obese children. J Korean Pediatr Soc 2001;44:992-1001
15 Kim WD. Pulmonary function test. In : Han YC, editors. Clinical pulmonology. 2nd ed. Seoul : Ilchokak, 1990:69-83
16 Hoffer EC, Meador CK, Simpson DC. Correlation of wholebody impedance with total water volume. J Appl Physiol 1969;27:531-4.
17 Park SW, Kim HM, Kim JS, Cha JK, Lee HR. Effects of obesity on pulmonary function in children. J Korean Pediatr Soc 2002;45:588-93
18 Lopata M, Onal E. Mass loading, sleep apnea and the pathogenesis of the obesity hypoventilation. Am Rev Respir Dis 1982;126:640-5
19 Kotler DP, Burastero S, Wang J, Richard RN Jr.. Prediction of body cell mass, fat-free mass, and total body water with bioelectrical impedance analysis : effects of race, sex, and disease. Am J Clin Nutr 1996;64(3 suppl):489S-97S
20 Zerah F, Harf A, Perlemuter L, Lorino H, Lorino AM, Atlan G. Effects of obesity on respiratory resistance. Chest 1993;103:1470-6   DOI   ScienceOn
21 Hong YM, Moon KR, Seo JW, Shim JG, Yoo KH, Jeong BJ, et al. Guideline of diagnosis and treatment in childhood obesity. J Korean Pediatr Soc 1999;42:1338-45
22 Bosisio E, Sergi M, di Natale B, Chiumello G. Ventilatory volumes, flow rates, transfer factor and its components (membrane component, capillary volume) in obese adults and children. Respiration 1984;45:321-6   DOI   ScienceOn
23 Hyatt RE, Flath RE. Relationship of air flow to pressure during maximal respiratory effort in man. J Appl Physio 1966;21:477-82
24 Ray RM, Senders CW. Airway management in the obese child. Pediatr Clin North Am 2001;48:1055-63   DOI   ScienceOn
25 Koenig SM. Pulmonary complication of obesity. Am J Med Sci 2001;321:249-79   DOI   PUBMED   ScienceOn
26 Guilleminault C, Simmons FB, Motta J, Cummiskey J, Rosekind M, Schoreder JS, et al. Obstructive sleep apnea syndrome and tracheostomy. Long-term follow up experience. Arch Intern Med 1981;141:985-8   DOI   ScienceOn
27 Lukaski HC, Bolonchuk WW. Estimation of body fluid volumes using tetrapolar bioelectrical impedance measurements. Aviot Space Environ Med 1988;59:1163-9
28 Yom HW, Kim SJ, Whang IT, Hong YM. Correlation between body fat percent estimated by bioelectrical impedance analysis and other variable methods. J Korean Pediatr Soc 2003;46:751-7
29 Segal KR, Gutin B, Presta E, Wang J, Van Itallic TB. Estimation of human body composition by electrical impedance methods : comperative study. J Appl Physol 1985;58: 1565-71
30 Derenne JP, Macklem PT, Roussos C. The respiratory muscles : mechanics, control and pathophysiology. Part III. Am Rev Respir Dis 1978;118:581-601
31 Ray CS, Sue DY, Bray G, Hansen JE, Wasserman K. Effects of obesity on respiratory function. Am Rev Respir Dis 1983;128:501-6
32 Unterborn J. Pulmonary fuction testing in obesity, pregnancy, and extremes of body habitus. Clin Chest Med 2001;22:759-67   DOI   PUBMED   ScienceOn