Browse > Article

Expression of Nerve Growth Factor during Urinary Bladder Development  

Lee, Kyoung Eun (Department of Pediatrics, College of Medicine, Hallym University)
Hong, Chang Hee (Department of Urology, College of Medicine, Hallym University)
Kang, Hee Jung (Department of Laboratory Medicine, College of Medicine, Hallym University)
Kim, Dug Ha (Department of Pediatrics, College of Medicine, Hallym University)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.4, 2005 , pp. 411-415 More about this Journal
Abstract
Purpose : This study was performed to determine the developmental expression pattern of nerve growth factor(NGF) in the urine of healthy children. It was hypothesized that NGF may contribute to the development of the spinobulbospinal micturition reflex that represents the adult micturition pattern. Methods : Voided urine was collected in 60 healthy children during the first 5 years of life(0-1 month, n=10; 1 month-1 year, n=10; 2 years, n=10; 3 years, n=10; 4 years, n=10). The urinary NGF was analyzed by using an enzyme linked immunosorbent assay. Results were normalized based on creatinine or total protein in urine. Results : NGF was significantly greater among neonates compared to other age groups(P<0.05). NGF levels declined during 1 month to 1 year and increased by age 2 years. NGF levels at age 3 years were less than in neonates examined. When comparing the NGF levels according to continence in children over 1 year old, NGF levels were significantly lower in children with continence than in children with incontinence(P<0.05). Conclusion : These data suggest that NGF is involved in the achievement of continence and in mechanisms of bladder nerve growth and in the reorganization of bladder reflex pathway.
Keywords
Nerve growth factor; Development; Urinary bladder;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Fitzgerald M. Development of pain mechanisms. Br Med Bull 1991;47:667-75
2 Lewin GR, Barde YA. Physiology of the neurotrophins. Annu Rev Neurosci 1996;19:289-317   DOI   ScienceOn
3 Bachelard M, Sillen U, Hansson S, Hermansson G, Jodal U, Jacobsson B. Urodynamic pattern in asymptomatic infants : siblings of children with vesicoureteral reflux. J Urol 1999;162;1733-8   DOI   ScienceOn
4 Lommatzsch M, Braun A, Mannsfeldt A, Botchkarev VA, Botchkareva NV, Paus R, et al. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia : implication for paracrine and target-derived neurotrophic functions. Am J Pathol 1999;155:1183-93   DOI   ScienceOn
5 Okragly AJ, Niles AL, Saban R, Schmidt D, Hoffman RL, Warner TF, et al. Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients. J Urol 1999;161:438-41   DOI   ScienceOn
6 Thor KB, Blais DP, de Groat WC. Behavioral analysis of the postnatal development of micturition in kittens. Brain Res Dev Brain Res 1989;46:137-44   DOI   ScienceOn
7 Vizzard MA, Erdman SL, Forstermann U, de Groat WC. Ontogeny of nitric oxide synthase in the lumbosacral spinal cord of the neonatal rat. Brain Res Dev Brain Res 1994; 81:201-17   DOI   ScienceOn
8 Bregman BS. Development of serotonin immunoreactivity in the rat spinal cord and its plasticity after neonatal spinal cord lesions. Brain Res 1987;431:245-63
9 Kawakami T, Wakabayashi Y, Aimi Y, Isono T, Okada Y. Developmental expression of glial cell-line derived neurotrophic factor, neurturin, and their receptor mRNA in the rat urinary bladder. Neurourol Urodyn 2003;22:83-8   DOI   ScienceOn
10 Marti E, Gibson SJ, Polak JM, Facer P, Springall DR, Van Aswegen G, et al. Ontogeny of peptide and amine containing neurones in motor, sensory, and autonomic regions of rat and human spinal cord, dorsal root ganglia and rat skin. J Comp Neurol 1987;266:332-59   DOI   ScienceOn
11 Lee KW, Kim JH, Kim YJ, Lee CH, Jeon YS, Lee NK. Voiding patterns in healthy korean children below 3 years old. Korean J Urol 2004;45:209-14
12 Maggi CA, Santicioli P, Geppeti S, Frilli MG, Spillantini MG, Nediani C, et al. Biochemical, anatomical and functional correlates of postnatal development of the capsaicinsensitive innervation of the rat urinary bladder. Brain Res 1988;471:183-90
13 Dines KC, Powell HC. Mast cell interactions with the nervous system : relationship to mechanisms of disease. J Neuropathol Exp Neurol 1997;56:627-40
14 Kruse MN, Tanowitz M, Chent C, de Groat WC. Postnatal development of the sensory innervation of the urinary bladder in the rat. Soc Neurosci 1990;16:1064
15 Steers WD, Kolbeck S, Creedon D, Tuttle JB. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 1991;88:1709-15   DOI   ScienceOn
16 de Groat WC, Nadelhaft I, Miline RJ, Booth AM, Morgan C, Thor K. Organization of the sacral parasympathetic reflex pathways to the urinary bladder and large intestine. J Auton Nerv Syst 1981;3:135-60   DOI   PUBMED   ScienceOn
17 Vizzard MA, Wu KH, Jewett IT. Developmental expression of urinary bladder neurotrophic factor mRNA and protein in the neonatal rat. Brain Res Dev Brain Res 2000;119:217-24   DOI   ScienceOn
18 de Groat WC. Plasticity of bladder reflex pathways during postnatal development. Physiol Behav 2002;77:689-92   DOI   PUBMED   ScienceOn
19 Vizzard MA. Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol 2000;161:273-84   DOI   PUBMED   ScienceOn
20 Jansson UB, Hanson M, Hanson E, Hellstrom AL, Sillen U. Voiding pattern in healthy children 0 to 3 years old : a longitudinal study. J Urol 2000;164:2050-4   DOI   ScienceOn
21 Wakabayashi Y, Kawakami T, Aimi Y, Okada Y. Development of growth-associated protein-43 and neurotrophin receptor immunoreactivities in the rat urinary bladder. Anat Embryol 2002;205:255-61   DOI   ScienceOn
22 Dupont MC, Persson K, Spitsbergen J, Tuttle JB, Steers WD. The neuronal response to bladder outlet obstruction, a role for NGF. Adv Exp Med Biol 1995;385:41-54
23 Kawakami T, Wakabayashi Y, Isono T, Aimi Y, Okada Y. Expression of neurotrophin messenger RNAs during rat urinary bladder development. Neurosci Lett 2002;329:77-80   DOI   ScienceOn
24 Oddiah D, Anand P, McMahon SB, Rattray M. Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder. Neuroreport 1998;9:1455-8   DOI   ScienceOn
25 Kim JC, Seo SI, Park YH, Hwang TK. Changes in detrusor and urinary growth factors according to detrusor function after partial bladder obstruction in the rat. Urology 2001;57:371-5   DOI   ScienceOn
26 Yeung CK, Godley ML, Dhillon HK, Duffy PG, Ransley PG. Urodynamic patterns in infants with normal lower urinary tracts or primary vesico-ureteric reflux. Br J Urol 1998;81:461-7   DOI