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Correlation of Body Mass Index, Body Fat Distribution, Aminotranferases and Computed Tomography in Obese Children with Fatty Liver  

Park, So Eun (Department of Pediatrics, Seoul National University College of Medicine)
Yang, Hye Ran (Department of Pediatrics, Seoul National University College of Medicine)
Chang, Ju Young (Department of Pediatrics, Seoul National University College of Medicine)
Ko, Jae Sung (Department of Pediatrics, Seoul National University College of Medicine)
Seo, Jeong Kee (Department of Pediatrics, Seoul National University College of Medicine)
Lee, Whal (Department of Radiology, Seoul National University College of Medicine)
Kim, Woo Sun (Department of Radiology, Seoul National University College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.3, 2005 , pp. 276-283 More about this Journal
Abstract
Purpose : Visceral fat accumulation plays a major role in metabolic complications of obesity. It is known that nonalcoholic fatty liver in obese adults is associated with visceral fat accumulation. Body mass index(BMI) is used as the index of obesity in children. The aim of this study is to evaluate the correlation of BMI and visceral adipose tissue(VAT), and the correlation of BMI, body fat distribution, aminotransferases, and severity of fatty liver. Methods : Twenty three obese children with fatty liver diagnosed by non-contrast abdominal computed tomography(CT) were included in this study. Data on BMI, aminotransferase levels were collected from clinical records. Visceral adipose area was evaluated with CT. Results : BMI had a singnificant correlation with VAT(r=0.51719, P=0.0115). The severity of fatty liver had no significant correlations with BMI(r=-0.11938, P=0.5876), VAT(r=-0.31234, P=0.1468), aspartate aminotransferase(AST)(r=0.12729, P=0.5628) or alanine aminotransferase(ALT)(r=-0.00179, P=0.9935). Conclusion : BMI in obese children was correlated with VAT. But the severity of fatty liver cannot be assessed by BMI, VAT or aminotransferase levels.
Keywords
Obesity; Fatty liver; Body mass index; Fat distribution; Computed tomography;
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1 Siegelman ES, Rosen MA. Imaging of hepatic steatosis. Semin Liver Dis 2001;21:71-80   DOI   ScienceOn
2 Lee DH. The incidence of complications in severely obese children. J Korean Pediatr Soc 1991;34:445-53
3 Maynard LM, Wisemandle W, Roche AF, Chumlea WC, Guo SS, Siervogel RM. Childhood body composition in relation to body mass index. Pediatrics 2001;107:344-50   DOI   PUBMED   ScienceOn
4 Figueroa-Colon R, Mayo MS, Treuth MS, Aldridge RA, Hunter GR, Berland L, et al. Variability of abdominal adipose tissue measurements using computed tomography in prepubertal girls. Int J Obes Relat Metab Disord 1998;22:1019-23   DOI   ScienceOn
5 McCullough AJ. Update on nonalcoholic fatty liver disease. J Clin Gastroenterol 2002;34:255-62   DOI   PUBMED   ScienceOn
6 Alba LM, Lindor K. Review article : non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2003;17:977-86   DOI   ScienceOn
7 Lee SH, Kim HJ, Oh JC, Han HJ, Kim HS, Tchach H, et al. Diagnosis of fatty liver complicated by simple obesity in children : serum ALT and its correlation with abdominal CT and liver biopsy. Korean J Pediatr Gastroenterol Nutr 1999;2:153-63
8 Guzzaloni G, Grugni G, Minocci A, Moro D, Morabito F. Liver steatosis in juvenile obesity : correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test. Int J Obes Relat Metab Disord 2000;24:772-6   DOI   ScienceOn
9 Bydder GM, Kreel L, Chapman RW, Harry D, Sherlock S, Bassan L. Accuracy of computed tomography in diagnosis of fatty liver. Br Med J 1980;281:1042   DOI   PUBMED
10 Fox K, Peters D, Armstrong N, Sharpe P, Bell M. Abdominal fat deposition in 11-year-old children. Int J Obes Relat Metab Disord 1993;17:11-6
11 Enzi G, Gasparo M, Biondetti PR, Fiore D, Semisa M, Zurlo F. Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography. Am J Clin Nutr 1986;44:739-46
12 Piekarski J, Goldberg HI, Royal SA, Axel L, Moss AA. Difference between liver and spleen CT numbers in the normal adult : its usefulness in predicting the presence of diffuse liver disease. Radiology 1980;137:727-9
13 Goto T, Onuma T, Takebe K, Kral JG. The influence of fatty liver on insulin clearance and insulin resistance in non-diabetic Japanese subjects. Int J Obes Relat Metab Disord 1995;19:841-5
14 Pietrobelli A, Faith MS, Allison DB, Gallagher D, Chiumello G, Heymsfield SB. Body mass index as a measure of adiposity among children and adolescents : a validation study. J Pediatr 1998;132:204-10   DOI   ScienceOn
15 Goran MI, Nagy TR, Treuth MS, Trowbridge C, Dezenberg C, McGloin A, et al. Visceral fat in white and African American prepubertal children. Am J Clin Nutr 1997;65:1703-8
16 Fisberg M, Baur L, Chen W, Hoppin A, Koletzko B, Lau D, et al. Obesity in children and adolescents : Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2004;39 Suppl 2:S678-87   DOI   ScienceOn
17 Tominaga K, Kurata JH, Chen YK, Fujimoto E, Miyagawa S, Abe I, et al. Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey. Dig Dis Sci 1995;40:2002-9   DOI   ScienceOn
18 de Ridder CM, de Boer RW, Seidell JC, Nieuwenhoff CM, Jeneson JA, Bakker CJ, et al. Body fat distribution in pubertal girls quantified by magnetic resonance imaging. Int J Obes Relat Metab Disord 1992;16:443-9
19 Kim HJ, Huh BY, Seo JK, Moon HR, Ji JK, Kim IW, et al. A case of fatty liver and fatty hepatitis in a obese child. Fam Physician 1988;9:22-6
20 Mahmood S, Taketa K, Imai K, Kajihara Y, Imai S, Yokobayashi T, et al. Association of fatty liver with increased ratio of visceral to subcutaneous adipose tissue in obese men. Acta Med Okayama 1998;52:225-31
21 Kral JG, Schaffner F, Pierson RN Jr, Wang J. Body fat topography as an independent predictor of fatty liver. Metabolism 1993;42:548-51   DOI   ScienceOn
22 Gates GF, Dore EK. Streamline flow in the human portal vein. J Nucl Med 1973;14:79-83
23 Brambilla P, Manzoni P, Sironi S, Simone P, Del Maschio A, di Natale B, et al. Peripheral and abdominal adiposity in childhood obesity. Int J Obes Relat Metab Disord 1994;18:795-800
24 Goran MI. Measurement issues related to studies of childhood obesity : assessment of body composition, body fat distribution, physical activity, and food intake. Pediatrics 1998;101:505-18
25 Lemieux S, Prud'homme D, Bouchard C, Tremblay A, Despres JP. Sex differences in the relation of visceral adipose tissue accumulation to total body fatness. Am J Clin Nutr 1993;58:463-7
26 Noguchi H, Tazawa Y, Nishinomiya F, Takada G. The relationship between serum transaminase activities and fatty liver in children with simple obesity. Acta Paediatr Jpn 1995;37:621-5   DOI
27 Hong YM, Seo JW, Sim JG, Yoo KW, Jeong BJ, Choe YH, et al. Guideline of diagnosis and treatment in childhood obesity. J Korean Pediatr Soc 1999;42:1338-65
28 Daniels SR, Khoury PR, Morrison JA. The utility of body mass index as a measure of body fatness in children and adolescents : differences by race and gender. Pediatrics 1997;99:804-7   DOI   ScienceOn
29 Nam SO. Correlation of obesity index, biochemical, histological, radiological study in obese children with fatty liver change. Seoul : Seoul National University, 1995
30 Goran MI, Kaskoun M, Shuman WP. Intra-abdominal adipose tissue in young children. Int J Obes Relat Metab Disord 1995;19:279-83
31 Slyper AH. Childhood obesity, adipose tissue distribution, and the pediatric practitioner. Pediatrics 1998;102:e4   DOI   ScienceOn
32 Caprio S, Hyman LD, McCarthy S, Lange R, Bronson M, Tamborlane WV. Fat distribution and cardiovascular risk factors in obese adolescent girls : importance of the intraabdominal fat depot. Am J Clin Nutr 1996;64:12-7
33 Fishbein MH, Miner M, Mogren C, Chalekson J. The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis. J Pediatr Gastroenterol Nutr 2003;36:54-61   DOI   ScienceOn
34 Kim HM, Hong YM, Kim GH, Yu JH. Predictor of fatty liver in obese children. J Korean Pediatr Soc 1996;39:803-10
35 Tazawa Y, Noguchi H, Nishinomiya F, Takada G. Serum alanine aminotransferase activity in obese children. Acta Paediatr 1997;86:238-41   DOI   ScienceOn
36 Grauer WO, Moss AA, Cann CE, Goldberg HI. Quantification of body fat distribution in the abdomen using computed tomography. Am J Clin Nutr 1984;39:631-7
37 Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002;123:745-50   DOI   ScienceOn
38 Scheen AJ, Luyckx FH. Obesity and liver disease. Best Practice Res Clin Endocrinol Metab 2002;16:703-16   DOI   ScienceOn
39 Kim SK, Kim SH, Rhee YM, Choi SH, You LC, Ahn CW, et al. The comparison of intra-abdominal fat distance(I-A Fat Distance) and visceral adipose tissue area(VAT) or visceral fat to skeletal muscle area ratio(VMR) measured by computed tomography(CT). Korean J Med 2003;64:49-59
40 Lim SW, Jeon MW, Park SA, Choi KD. The clinical usefulness of serum aminotrasnferse activities for predicting fatty liver in obese children. Korean J Pediatr Gastroenterol Nutr 2003;6:174-82
41 Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S. A novel technique for the determination of body fat by computed tomography. Int J Obes 1983;7:437-45
42 Brunt EM. Nonalcoholic steatohepatitis. Semin Liver Dis 2004;24:3-20
43 Borkan GA, Gerzof SG, Robbins AH, Hults DE, Silbert CK, Silbert JE. Assessment of abdominal fat content by computed tomography. Am J Clin Nutr 1982;36:172-7