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Helper T Cell Polarizing Through Dendritic Cells  

Han, Manyong (Department of Pediatrics, College of Medicine, Pochon CHA University)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.1, 2005 , pp. 6-12 More about this Journal
Abstract
In the last few years, a spectrum of dendritic cells(DCs), including toll like receptors(TLRs), might play a critical role in regulating allergy and asthma. DC plays a central role in initiating immune responses, linking innate and adaptive responses to pathogen. Human peripheral blood has three non-overlapping dendritic subset that expressed various 11 TLRs. These dendritic subsets and TLR contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. A better understanding of DC immunobiology may lead to the comprehension of allergy pathophysiology to prevent early stage allergic march.
Keywords
Toll like receptor; Plasmacytoid dendritic cell; Myeloid dendritic cell; Th1/Th2 deviation;
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