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Serum Insulin, Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 Levels in Obese Adolescents  

Kwon, Jung Hyun (Department of Pediatrics, College of Medicine, Ewha Womans University)
Kim, Hyun Jin (Department of Pediatrics, College of Medicine, Ewha Womans University)
Hong, Young Mi (Department of Pediatrics, College of Medicine, Ewha Womans University)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.11, 2005 , pp. 1172-1178 More about this Journal
Abstract
Purpose : Childhood Obesity is increasing throughout the world, and it is known to incur many diseases especially in later life such as diabetes and cardiovascular disorders. The purpose of this study was to investigate the association between obesity and insulin, insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3(IGFBP-3) and know if these factors are useful in predicting cardiovascular diseases. Methods : The study group consisted of 64 moderate and severe obese adolescents and the controls were normal adolescents of the same age. body mass index(BMI) was calculated by height and weight; systolic and diastolic blood pressure was measured at resting state. After 10-hour fasting period, blood cholesterol, triglyceride, high density lipoprotein(HDL) cholesterol, low density lipoprotein(LDL) cholesterol, glucose, insulin, free fatty acid, IGF-I and IGFBP-3 were measured. Results : Insulin was significantly higher in the obese adolescent group than the control group(obese group $15.6{\pm}7.0{\mu}IU/mL$, P<0.01). IGF-I was also significantly higher in the obese adolescent group than the control group(obese group $498.1{\pm}122.2ng/mL$, P<0.05). In addition, IGFBP-3 was significantly higher in the obese adolescent group than the control group(obese group $3,777{\pm}4,721ng/mL$, P<0.05). Insulin showed significantly positive correlation with BMI(r=0.3944) and obesity index(r=0.34). IGFBP-3 were significantly correlated with obesity index(r=0.419), diastolic blood pressure (r=0.264) and BMI(r=0.247). Insulin resistance index significantly positive correlation with BMI(r=0.595), blood triglycerid level(r=0.515) and obesity index(r=0.469). Conclusion : Serum insulin, insulin resistance index, IGF-I and IGFBP-3 levels may be useful to predict cardiovascular diseases in adolescent obesity.
Keywords
Obesity; Insulin; Insulin resistance index; IGF-1; IGFBP-3;
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1 Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics 2001;107:E55   DOI   ScienceOn
2 Hong YM, Moon KR, Seo JW, Sim JG, Yoo KW, Jeong BJ, et al. National wide study on body mass index, skinfold thickness, arm circumference in Korean children. Korean J Pediatr 1999;42:1186-206
3 Schulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000;106:171-6   DOI   ScienceOn
4 Gascon F, Valle M, Martos R, Zafra M, Morales R, Castano MA. Childhood obesity and hormonal abnormalities associated with cancer risk. Eur J Cancer Prev 2004;13: 193-7   DOI
5 Ben-shlomo Y, Holly J, McCarthy A, Savage P, Davies D, Gunnell D, et al. An investigation of fetal, postnatal and childhood growth with insulin-like growth factor-I and binding protein 3 in adulthood. Clinical Endocrinol 2003;59: 366-73   DOI   ScienceOn
6 Diez J, Ruilope LM, Rodicio JL. Insulin response to oral glucose in essential hypertensives with increased circulating levels of insulin growth factor 1. J Hypertens Suppl 1991;9:S174-5
7 Gomez JM, Maravall FJ, Gomez N, Navarro MA, Casamitjana R, Soler J. The IGF-1 system component concentrations that decrease with aging are lower in obesity in relationship to body mass index and body fat. Growth Horm IGF Res 2004;14:91-6.   DOI   ScienceOn
8 Teramukai S, Rohan T, Eguchi H, Oda T, Shinchi K, Kono S. Anthropometric and behavioral correlates of insulin- like growth factor I and insulin-like growth factor binding protein 3 in middle-aged Japanese men. Am J Epidemiol 2002;156:344-8   DOI   ScienceOn
9 Schoen RL, Schragin J, Weissfeld JL, Thaete FL, Evans RW, Rosen CJ, et al. Lack of association between adipose tissue distribution and IGF-1 and IGFBP-3 in men and women. Cancer Epidemiol Biomark Prev 2002;11:581-6
10 Probst-Hensch NM, Yuan JM, Stanczyk FZ, Gao YT, Ross RK, Yu MC. IGF-1, IGF-2 and IGPBP-3 in prediagnostic serum : association with colorectal cancer in a cohort of Chinese men in Shanghi. Br J Cancer 2001;85:1695-9   DOI   ScienceOn
11 Wolk K, Larsson SC, Vessby B, Wolk A, Brismar K. Metabolic, anthropometric, and nutritional factors as predictors of circulating insulin-like growth factor binding protein-1 levels in middle-aged and elderly men. J Clin Endocrinol Metab 2004;89:1879-84   DOI   ScienceOn
12 Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Inves 1996;97:2601-10   DOI   ScienceOn
13 Sigal RJ, EL-Hashimy M, Martin BC, Soeldner JC, Krolewski AS, Warram JH, et al. Acute postchallenge hyperinsulinemia predicts weight gain : A prospective study. Diabetes 1997;46:1025-9   DOI   ScienceOn
14 Gayet C, Bailhache E, Dumon H, Martin L, Siliart B, Nguyen P. Insulin resistance and changes in plasma concentration of TNF alpha, IGF1, and NEFA in dogs during weight gain and obesity. J Anim Physiol Anim Nutr 2004;88:157- 65   DOI   ScienceOn
15 Andronico G, Mangano MT, Nardi E, Mule G, Piazza G, Cerasola G, et al. Insulin-like growth factor 1 and sodiumlithium countertransport in essential hypertensioin and in hypertensive left ventricular hypertrophy. J Hypertens 1993; 11:1097-101.   DOI   ScienceOn
16 Casbi G, Torok K, Jeges S, Molnar D. Presence of metabolic cardiovascular syndrome in obese children. Eur J Pediatr 2000;159:91-4   DOI   ScienceOn
17 Decsi T, Molnar D. Insulin resistance syndrome in children : pathophysiology and potential management strategies. Pediatr Drugs 2003;5:291-9   DOI
18 Bayes-Genis A, Conover CA, Schwarz RS. The insulin-like growth factor axis : a review of atherosclerosis and restenosis. Cir Res 2000;86:125-30   DOI   ScienceOn
19 Baumann G, Shaw MA, Ambum K. Circulating growth hormone binding proteins. J Endocrinol Invest 1994;17:67- 81   DOI
20 Sabin MA, Crowne EC, Shield JPH. The prognosis in childhood obesity. Curr Paediatr 2004;14:110-4   DOI   ScienceOn
21 Molnar D, Torok K, Erhardt E, Jeges S. Safety and efficacy of treatment with an ephedrine/caffeine mixture : the first double-blind placebo-controlled pilot study in adolescents. Int J Obes Relat Metab Disord 2000;24:1573-8   DOI   ScienceOn
22 Yamamoto H, Kato Y. Relationship between plasma insulin- like growth factor I(IGF-1) levels and body mass indices( BMI) in adults. Endocr J 1993;40:41-5   DOI   ScienceOn
23 Vaccaro F, Cianfarani S, Pasquino AM, Boscherini B. Is obesity-related insulin status the cause of blunted growth hormone secretion in Turner's syndrome? Metabolism 1995; 44:1033-7   DOI   ScienceOn
24 Kunitomi M, Wada J, Takahashi K, Tsuchiyama Y, Mimura Y, Hida K, et al. Relationship between reduced serum IGF-1 levels and accumulation of visceral fat in Japanese men. Int J Obes Relat Metab Disord 2002;26:361-9   DOI   ScienceOn
25 Sandhu MS, Gibson JM, Heald AH, Dunger DB, Wareham NJ. Association between insulin-like growth factor-1: insulin- like growth factor-binding protein-1 ratio and metabolic and anthropometric factors in men and women. Cancer Epidemiol Biomarkers Prev 2004;13:166-70   DOI   ScienceOn
26 Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, Rosseto R, et al. Relationships between IGF-1 and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes Relat Metab Disor 1999;23:612-8   DOI   ScienceOn
27 Heald AH, Anderson SG, Ivison F, Laing I, Gibson JM, Cruickshank K. C-reactive protein and the insulin-like growth factor(IGF)-system in relation to risk of cardiovascular disease in different ethnic groups. Atherosclerosis 2003;170:79-86   DOI   ScienceOn