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Airway Remodelling in Asthma  

Lim, Dae Hyun (Department of Pediatrics, College of Medicine, Inha University)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.10, 2005 , pp. 1038-1049 More about this Journal
Abstract
Asthma is characterized by a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodelling. Characteristic changes of airway remodelling in asthma include goblet cell hyperplasia, deposition of collagens in the basement membrane, increased number and size of microvessels, hypertrophy and hyperplasia of airway smooth muscle, and hypertrophy of submucosal glands. Apart from inflammatory cells, such as eosinophils, activated T cells, mast cells and macrophages, structural tissue cells such as epithelial cells, fibroblasts and smooth muscle cells can also play an important effector role through the release of a variety of mediators, cytokines, chemokines, and growth factors. Through a variety of inflammatory mediators, epithelial and mesenchymal cells cause persistence of the inflammatory infiltrate and induce airway structural remodelling. The end result of chronic airway inflammation and remodelling is an increased thickness of the airway wall, leading to a increased the bronchial hyperresponsiveness and fixed declined lung function.
Keywords
Asthma; Remodelling;
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1 Wiggs BR, Moreno R, Hogg JC, Hilliam C, Pare PD. A model of the mechanics of airway narrowing. J Appl Physiol 1990;69:849-60
2 Weiss ST, Van Natta ML, Zeiger RS for the Childhood Asthma Management Program Research Group. Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program. Am J Respir Crit Care Med 2000;162:50-6   DOI   ScienceOn
3 The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000;343:1054-63   DOI   ScienceOn
4 Palmans E, Kips JC, Pauwels RA. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Respir Crit Care Med 2000;161:627-35   DOI   ScienceOn
5 Awadh N, Muller NL, Park CS, Abboud RT, FitzGerald JM. Airway wall thickness in patients with near fatal asthma and control groups : assessment with high resolution computed tomographic scanning. Thorax 1998;53:248-53   DOI   ScienceOn
6 Niimi A, Matsumoto H, Amitani R, Nakano Y, Mishima M, Minakuchi M, et al. Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. Am J Respir Crit Care Med 2000;162:1518-23   DOI   ScienceOn
7 Huang J, Olivenstein R, Taha R, Hamid Q, Ludwig M. Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am J Respir Crit Care Med 1999;160:725-9   DOI   ScienceOn
8 Carroll NG, Perry S, Karkhanis A, Harji S, Butt J, James AL, et al. The airway longitudinal elastic fiber network and mucosal folding in patients with asthma. Am J Respir Crit Care Med 2000;161:244-8   DOI   ScienceOn
9 Brackel HJ, Pedersen OF, Mulder PG, Overbeek SE, Kerrebijn KF, Bogaard JM. Central airways behave more stiffly during forced expiration in patients with asthma. Am J Respir Crit Care Med 2000;162:896-904   DOI   ScienceOn
10 Salmon M, Walsh DA, Koto H, Barnes PJ, Chung KF. Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling. Eur Respir J 1999;14:633-41   DOI   ScienceOn
11 Krymskaya VP, Penn RB, Orsini MJ, Scott PH, Plevin RJ, Walker TR, et al. Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol 1999;277:L65-78
12 Hogg JC. Airway behavior and its regulation : How do structural changes affect airway behavior? Am J Respir Crit Care Med 1996;153:S16-8   DOI
13 Krymskaya VP, Hoffman R, Eszterhas A, Kane S, Ciocca V, Panettieri RA Jr. EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. Am J Physiol 1999;276:L246-55
14 Woolcock AJ, Salome CM, Yan K. The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am Rev Respir Dis 1984;130:71-5
15 Lambert RK, Codd SL, Alley MR, Pack RJ. Physical determinants of bronchial mucosal folding. J Appl Physiol 1994;77:1206-16
16 Lambert RK, Codd SL, Alley MR, Pack RJ. Physical determinants of bronchial mucosal folding. J Appl Physiol 1994;77:1206-16
17 Bramley AM, Roberts CR, Schellenberg RR. Collagenase increases shortening of human bronchial smooth muscle in vitro. Am J Respir Crit Care Med 1995;152:1513-7   DOI   ScienceOn
18 Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998;339:1194-200   DOI   ScienceOn
19 Bousquet J, Jeffery PK, Busse WB, Johnson M, Vignola AM. Asthma : from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720-45   DOI   ScienceOn
20 Weiss ST, Tosteson TD, Segal MR, Tager IB, Redline S, Speizer FE. Effects of asthma on pulmonary function in children. A longitudinal population-based study. Am Rev Respir Dis 1992;145:58-64   DOI   ScienceOn
21 Vanacker NJ, Palmans E, Pauwels RA, Kips JC. Fluticasone inhibits the progression of allergen-induced structural airway changes. Clinical & Experimental Allergy 2002;32:914-20   DOI   ScienceOn
22 Niimi A, Matsumoto H, Minakuchi M, Kitaichi M, Amitani R. Airway remodelling in cough variant asthma [letter]. Lancet 2000;356:564-5.   DOI   ScienceOn
23 Macklem PT. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med 1996;153:83-9   DOI   ScienceOn
24 Macklem PT. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med 1996;153:83-9   DOI   ScienceOn
25 Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000;105:193-204   DOI   ScienceOn
26 Demoly P, Maly FE, Mautino G, Grad S, Gougat C, Sahla H, et al. VEGF levels in asthmatic airways do not correlate with plasma extravasation. Clin Exp Allergy 1999;29:1390-4   DOI   ScienceOn
27 Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Pare PD. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993;74:2771-81   DOI   ScienceOn
28 Huber HL, Koessler KK. The pathology of bronchial asthma. Arch Int Med 1922;30:689-760   DOI
29 Dunnill MS, Massarella GR. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 1969;24:176-9   DOI   ScienceOn
30 Jeffery PK, Laitinen A, Venge P. Biopsy markers of airway inflammation and remodelling. Respir Med 2000;Suppl 1:S9-15
31 Hoshino M, Takahashi M, Takai Y, Sim J. Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. J Allergy Clin Immunol 1999;104:356-63   DOI   ScienceOn
32 Palmans E, Kips JC, Pauwels RA. The effect of chronic allergen exposure on airway structure and responsiveness in rats. Am J Respir Crit Care Med 2000;161:627-35   DOI   ScienceOn
33 James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-6   DOI   ScienceOn
34 Ulrik CS, Backer V, Dirksen A. A 10 year follow up of 180 adults with bronchial asthma : factors important for the decline in lung function. Thorax 1992;47:14-8   DOI   ScienceOn
35 Cassino C, Berger KI, Goldring RM, Norman RG, Kammerman S, Ciotoli C, et al. Duration of asthma and physiologic outcomes in elderly nonsmokers. Am J Respir Crit Care Med 2000;162:1423-8   DOI   ScienceOn
36 Mautino G, Henriquet C, Jaffuel D, Bousquet J, Capony F. Tissue inhibitor of metalloproteinase-1 levels in bronchoalveolar lavage fluid from asthmatic subjects. Am J Respir Crit Care Med 1999;160:324-30   DOI   ScienceOn
37 Sterk PJ, Bel EH. The shape of the dose-response curve to inhaled bronchoconstrictor agents in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991;143:1433-7   DOI   ScienceOn
38 Moreno RH, Hogg JC, Pare PD. Mechanics of airway narrowing. Am Rev Respir Dis 1986;133:1171-80
39 Hamann KJ, Dorscheid DR, Ko FD, Conforti AE, Sperling AI, Rabe KF, et al. Expression of Fas(CD95) and FasL(CD95L) in human airway epithelium. Am J Respir Cell Mol Biol 1998;19:537-42   DOI   ScienceOn
40 Wiggs BR, Hrousis CA, Drazen JM, Kamm RD. On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol 1997;83:1814-21
41 Hamann KJ, Ko FD, Padrick ML, Leff AR. Expression of Fas(CD95/APO-1), Bcl-2 and ICE proteins, CPP32 and Ich-1L in developing human cord blood-derived eosinophils(CDE) (Abstract). Am J Respir Crit Care Med 1997;155:A62
42 Gillis HL, Lutchen KR. Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness. J Appl Physiol 1999;86:2001-12   DOI   ScienceOn
43 Saetta M, Di-Stefano A, Maestrelli P, De Marzo N, Milani GF, Pivirotto F, et al. Airway mucosal inflammation in occupational asthma induced by toluene diisocyanate. Am Rev Respir Dis 1992;145:160-8   DOI   ScienceOn
44 James AL, Pare PD, Moreno RH, Hogg JC : Quantitative measurement of smooth muscle shortening in isolated pig trachea. J Appl Physiol 1987;63:1360-5
45 Gelb AF, Zamel N. Unsuspected pseudophysiologic emphysema in chronic persistent asthma. Am J Respir Crit Care Med 2000;162:1778-82   DOI   ScienceOn
46 Battegay EJ. Angiogenesis : mechanistic insights, neovascular diseases, and therapeutic prospects. J Mol Med 1995;73:333-46
47 Naureckas ET, Ndukwu IM, Halayko AJ, Maxwell C, Hershenson MB, Solway J. Bronchoalveolar lavage fluid from asthmatic subjects is mitogenic for human airway smooth muscle. Am J Respir Crit Care Med 1999;160:2062-6   DOI   ScienceOn
48 Sont JK, Luuk NA, Willems LN, Bel EH, van Krieken HM, Vandenbroucke JP, et al., and the AMPUL Study Group. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 1999;159:1043-51   DOI
49 Hamann KJ, Vieira JE, Halayko AJ, Dorscheid D, White SR, Forsythe SM, et al. Fas cross-linking induces apoptosis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2000;278:L618-24
50 Johnson S, Knox A. Autocrine production of matrix metal-loproteinase -2 is required for human airway smooth muscle. proliferation. Am J Physiol 1999;277:L1109-17
51 Brown RH, Zerhouni EA, Mitzner W. Airway edema potentiates airway reactivity. J Appl Physiol 1995;79:1242-8
52 Gizycki MJ, Adelroth E, Rogers AV, O'Byrne PM, Jeffery PK. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 1997;16:664-73   DOI   ScienceOn
53 Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, Laurent GJ, et al. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Cell Mol Physiol 2000;278:L193-201
54 Cho SH, Tam SW, Demissie-Sanders S, Filler SA, Oh CK. Production of plasminogen activator inhibitor-1 by human mast cells and its possible role in asthma. J Immunol 2000;165:3154-61
55 Backman KS, Greenberger PA, Patterson R. Airways obstruction in patients with long-term asthma consistent with 'irreversible asthma'. Chest 1997;112:1234-40   DOI   ScienceOn
56 Laitinen LA, Laitinen A, Widdicombe J. Effects of inflammatory and other mediators on airway vascular beds. Am Rev Respir Dis 1987;135:S67-70
57 Bramley AM, Roberts CR, Schellenberg RR. Collagenase increases shortening of human bronchial smooth muscle in vitro. Am J Respir Crit Care Med 1995;152:1513-7   DOI   ScienceOn
58 James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-6   DOI   ScienceOn
59 James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-6   DOI   ScienceOn
60 Meiss RA. Influence of intercellular tissue connections on airway muscle mechanics. J Appl Physiol 1999;86:5-15
61 Wilkinson MG, Millar JB. Control of the eukaryotic cell cycle by MAP kinase signaling pathways. FASEB J 2000;14:2147-57   DOI   ScienceOn
62 Mauad T, Xavier AC, Saldiva PH, Dolhnikoff M. Elastosis and fragmentation of fibers of the elastic system in fatal asthma. Am J Respir Crit Care Med 1999;160:968-75   DOI   ScienceOn
63 Moreno RH, Hogg JC, Pare PD. Mechanics of airway narrowing. Am Rev Respir Dis 1986;133:1171-80
64 Meiss RA. Influence of intercellular tissue connections on airway muscle mechanics. J Appl Physiol 1999;86:5-15
65 Tanaka H, Miyazaki N, Oashi K, Tanaka S, Ohmichi M, Abe S. Sputum matrix metalloproteina se-9:tissue inhibitor of metalloproteinase-1 ratio in acute asthma. J Allergy Clin Immunol 2000;105:900-5   DOI   ScienceOn
66 Brusasco V, Crimi E, Barisione G, Spanevello A, Rodarte JR, Pellegrino R. Airway responsiveness to methacholine : effects of deep inhalations and airway inflammation. J Appl Physiol 1999;87:567-73
67 Vignola AM, Kips J, Bousquet J. Tissue remodeling as a feature of persistent asthma. J Allergy Clin Immunol 2000;105:1041-53   DOI   ScienceOn
68 Becky Kelly EA, Busse WW, Jarjour NN. Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am J Respir Crit Care Med 2000;162:1157-61   DOI   ScienceOn
69 Wiggs BR, Hrousis CA, Drazen JM, Kamm RD. On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol 1997;83:1814-21
70 Wagner EM, Liu MC, Weinmann GG, Permutt S, Bleecker ER. Peripheral lung resistance in normal and asthmatic subjects. Am Rev Respir Dis 1990;141:584-8   DOI   ScienceOn
71 Teran LM, Mochizuki M, Bartels J, Valencia EL, Nakajima T, Hirai K, et al. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am J Respir Cell Mol Biol 1999;20:777-86   DOI   ScienceOn
72 King GG, Pare PD, Seow CY. The mechanics of exaggerated airway narrowing in asthma : the role of smooth muscle. Respir Physiol 1999;118:1-13   DOI   ScienceOn
73 Orsida BE, Li X, Hickey B, Thien F, Wilson JW, Walters EH. Vascularity in asthmatic airways : relation to inhaled steroid dose. Thorax 1999;54:289-95   DOI   ScienceOn
74 Kuhn C, Homer RJ, Zhu Z, Ward N, Flavell RA, Geba GP, et al. Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin(IL)-11 and IL-6 in the lung. Am J Respir Cell Mol Biol 2000;22:289-95   DOI   ScienceOn
75 Chu HW, Halliday JL, Martin RJ, Leung DY, Szefler SJ, Wenzel SE. Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am J Respir Crit Care Med 1998;158:1936-44   DOI   ScienceOn
76 Mautino G, Henriquet C, Gougat C, Le Cam A, Dayer JM, Bousquet J, et al. Increased expression of tissue inhibitor of metalloproteinase -1 and loss of correlation with matrix metalloproteinase-9 by macrophages in asthma. Lab Invest 1999;79:39-47
77 Boulet LP, Turcotte H, Laviolette M, Naud F, Bernier MC, Martel S, et al. Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids. Am J Respir Crit Care Med 2000;162:1308-13   DOI   ScienceOn
78 Holgate ST. Epithelial damage and response. Clin Exp Allergy 2000;30(Suppl 1):37-41   DOI   ScienceOn