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Familial Adenomatous Polyposis Improved by COX-2 Inhibitor in a Child  

Oh, Ki Won (Department of Pediatrics, Kyungpook National University School of Medicine)
Kim, Se Young (Department of Pediatrics, Kyungpook National University School of Medicine)
Lee, Hwan Suk (Department of Pediatrics, Kyungpook National University School of Medicine)
Lee, Myung Hoon (Department of Pathology, Kyungpook National University School of Medicine)
Choe, Byung Ho (Department of Pediatrics, Kyungpook National University School of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.45, no.12, 2002 , pp. 1591-1595 More about this Journal
Abstract
Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of FAP in a 9-year-old female whose polyposis regressed markedly after six months-treatment with celecoxib.
Keywords
Familial adenomatous polyposis; NSAID; COX-2 inhibitor; Celecoxib;
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