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Iodixanol-Induced Fixed Drug Eruption Diagnosed by Systemic Provocation Test  

Jin, Sang Yun (Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University)
Kim, Do Hun (Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University)
Choi, Yun Seok (Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University)
Kwon, Jae Hyun (Department of Radiology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University)
Lee, Ai Young (Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University)
Lee, Seung Ho (Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University)
Publication Information
Korean journal of dermatology / v.50, no.12, 2012 , pp. 1073-1076 More about this Journal
Abstract
Most cases of delayed skin reactions attributed to non-ionic iodinated contrast media, reported to date, have been maculopapular rash, which frequently occurs on the trunk and proximal region of the extremities. Only few cases of fixed drug eruption caused by non-ionic iodinated contrast media have been reported. A 48-year-old man developed multiple sharply marginated, hyperpigmented, oval patches on the trunk and extremities after receiving iodixanol (Visipaque$^{(R)}$, GE healthcare, USA). The patch test was carried out with a panel of the available iodinated non-ionic contrast media, but did not induce a positive reaction to any of the tested contrast media. The provocation test was carried out with iodixanol as 1/10 of the amount administered during the procedure that caused the reaction. On the following morning, the lesions increased in size and number. We report a case of iodixanol-induced fixed drug eruption, diagnosed by a systemic provocation test.
Keywords
Contrast media; Delayed reactions; Fixed drug eruption; Iodixanol; Systemic provocation test;
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