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http://dx.doi.org/10.5021/ad.2018.30.6.662

Increasing Prevalence of the Sensitization to Cat/Dog Allergens in Korea  

Park, Bok Won (Department of Dermatology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University)
Park, Jun Yeong (Department of Dermatology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University)
Cho, Eun Byul (Department of Dermatology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University)
Park, Eun Joo (Department of Dermatology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University)
Kim, Kwang Ho (Department of Dermatology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University)
Kim, Kwang Joong (Department of Dermatology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University)
Publication Information
Annals of dermatology / v.30, no.6, 2018 , pp. 662-667 More about this Journal
Abstract
Background: Recently, the number of domestic pets has increased. As a consequence, sensitization to animal allergens, such as cat or dog allergens, has become a problem. Objective: We studied the annual trends of sensitization to cats or dogs, and the characteristics of the patients. Methods: We retrospectively analyzed the medical records of 7,469 patients who visited a dermatology clinic and underwent an allergic profile test, from January 2011 to December 2015. Specific immunoglobulin E (IgE) levels to cat or dog antibody greater than 3.50 IU/ml were regarded as positive results. Results: In all, 274 patients showed significant increase in levels of specific IgE antibody to dog, and 307 revealed increase in levels of of specific IgE antibody to cat. The prevalence of these specific IgEs increased from 2011 to 2015. Independent risks for sensitization to cat allergens were sensitization to dog, but not to house dust, Dermatophagoides pteronyssinus, and D. farinae. Independent risks for sensitization to dog allergens were sensitization to cat, but not to house dust, D. pteronyssinus, and D. farinae. Total IgE level was not related to specific IgE level against either cats or dogs. Conclusion: In conclusion, the prevalence of sensitization to cat or dog has increased. Sensitization to cat or dog is related to each other, but is irrelevant to the total IgE level.
Keywords
Atopic dermatitis; Cat; Dog; Specific immunoglobulin E;
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1 Calabria CW, Dietrich J, Hagan L. Comparison of serumspecific IgE (ImmunoCAP) and skin-prick test results for 53 inhalant allergens in patients with chronic rhinitis. Allergy Asthma Proc 2009;30:386-396.   DOI
2 Jung YG, Cho HJ, Park GY, Min JY, Kim HY, Dhong HJ, et al. Comparison of the skin-prick test and Phadia Immuno-CAP as tools to diagnose house-dust mite allergy. Am J Rhinol Allergy 2010;24:226-229.   DOI
3 Koh HS, Lee KS, Han DH, Rah YH, Choi SH. Relationship between serum total IgE, specific IgE, and peripheral blood eosinophil count according to specific allergic diseases. Allergy Asthma Respir Dis 2013;1:123-128.   DOI
4 Yilmaz I, Oner Erkekol F, Secil D, Misirligil Z, Mungan D. Cat and dog sensitization in pet shop workers. Occup Med 2013;63:563-567.   DOI
5 Custovic A, Hallam CL, Simpson BM, Craven M, Simpson A, Woodcock A. Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol 2001;108:537-539.   DOI
6 Custovic A, Simpson BM, Simpson A, Hallam CL, Marolia H, Walsh D, et al. Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults. J Allergy Clin Immunol 2003;111:402-407.   DOI
7 Enberg RN, Shamie SM, McCullough J, Ownby DR. Ubiquitous presence of cat allergen in cat-free buildings: probable dispersal from human clothing. Ann Allergy 1993;70:471-474.
8 D'Amato G, Liccardi G, Russo M, Barber D, D'Amato M, Carreira J. Clothing is a carrier of cat allergens. J of Allergy Clin Immunol 1997;99:577-578.   DOI
9 Patchett K, Lewis S, Crane J, Fitzharris P. Cat allergen (Fel d 1) levels on school children's clothing and in primary school classrooms in Wellington, New Zealand. J Allergy Clin Immunol 1997;100:755-759.   DOI
10 Almqvist C, Larsson PH, Egmar AC, Hedren M, Malmberg P, Wickman M. School as a risk environment for children allergic to cats and a site for transfer of cat allergen to homes. J Allergy Clin Immunol 1999;103:1012-1017.   DOI
11 Custovic A, Simpson A, Chapman MD, Woodcock A. Allergen avoidance in the treatment of asthma and atopic disorders. Thorax 1998;53:63-72.   DOI
12 Partti-Pellinen K, Marttila O, Makinen-Kiljunen S, Haahtela T. Occurrence of dog, cat, and mite allergens in public transport vehicles. Allergy 2000;55:65-68.   DOI
13 Chan-Yeung M, McClean PA, Sandell PR, Slutsky AS, Zamel N. Sensitization to cat without direct exposure to cats. Clin Exp Allergy 1999;29:762-765.   DOI
14 Kim TB, Kim KM, Kim SH, Kang HR, Chang YS, Kim CW, et el. Sensitization rates for inhalant allergens in Korea; a multi-center study. J Asthma Allergy Clin Immunol 2003;23:483-493.
15 Svanes C, Zock JP, Anto J, Dharmage S, Norback D, Wjst M, et al. Do asthma and allergy influence subsequent pet keeping? An analysis of childhood and adulthood. J Allergy Clin Immunol 2006;118:691-698.   DOI
16 Kim J, Hahm MI, Lee SY, Kim WK, Chae Y, Park YM, et al. Sensitization to aeroallergens in Korean children: a populationbased study in 2010. J Korean Med Sci 2011;26:1165-1172.   DOI
17 Lee SE, Kim JY, Kim YA, Cho SH, Ahn HJ, Woo HM, et al. Prevalence of Toxoplasma gondii infection in stray and household cats in regions of Seoul, Korea. Korean J Parasitol 2010;48:267-270.   DOI
18 Spitzauer S, Pandjaitan B, Muhl S, Ebner C, Kraft D, Valenta R, et al. Major cat and dog allergens share IgE epitopes. J Allergy Clin Immunol 1997;99:100-106.
19 Linneberg A, Nielsen NH, Madsen F, Frolund L, Dirksen A, Jorgensen T. Pets in the home and the development of pet allergy in adulthood. The Copenhagen allergy study. Allergy 2003;58:21-26.   DOI
20 Madhurantakam C, Nilsson OB, Uchtenhagen H, Konradsen J, Saarne T, Hogbom E, et al. Crystal structure of the dog lipocalin allergen can f 2: implications for cross-reactivity to the cat allergen Fel d 4. J Mol Biol 2010;401:68-83.   DOI
21 Erwin EA, Ronmark E, Wickens K, Perzanowski MS, Barry D, Lundback B, et al. Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence. J Allergy Clin Immunol 2007;119:359-365.   DOI
22 Yoo KY, Cho SH, Gin Y, Lee YJ. Strategic guidelines to protect and manage pet animals in Seoul (SDI 04-R-21). Seoul: The Seoul Institute, 2004.
23 Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI. Global variations in prevalence of eczema symptoms in children from ISAAC phase three. J Allergy Clin Immunol 2009;124:1251-1258.   DOI
24 Lee JH, Han KD, Kim KM, Park YG, Lee JY, Park YM. Prevalence of atopic dermatitis in Korean children based on data from the 2008-2011 Korean national health and nutrition examination survey. Allergy Asthma Immunol Res 2016;8:79-83.   DOI
25 Plaschke P, Janson C, Norrman E, Bjornsson E, Ellbjar S, Jarvholm B. Association between atopic sensitization and asthma and bronchial hyperresponsiveness in Swedish adults: pets, and not mites, are the most important allergens. J Allergy Clinl Immunol 1999;104:58-65.   DOI
26 Korean gallup. Pet ownership status and awareness survey in Korea. Seoul: Korea Pet Food Association; 2017. 58 p.