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A Study on Contents of Anti-impotence drug/drug-like compounds in Food  

Hong, Hae-Geun (North branch Gyeonggido Institute of Health & Environment)
Bang, Seon-Jae (North branch Gyeonggido Institute of Health & Environment)
Park, Kwang-Hee (North branch Gyeonggido Institute of Health & Environment)
Lee, In-Sook (North branch Gyeonggido Institute of Health & Environment)
Park, In-Jung (North branch Gyeonggido Institute of Health & Environment)
Park, Jeung-Hwa (North branch Gyeonggido Institute of Health & Environment)
Kim, Jong-Chan (North branch Gyeonggido Institute of Health & Environment)
Publication Information
Journal of environmental and Sanitary engineering / v.22, no.3, 2007 , pp. 89-96 More about this Journal
Abstract
To determine 8 anti-impotence drug/drug-like compounds such as sildenafil, vardenafil, tadalafil, homosildenafil, hydroxyhomosildenafil, aminotadalafil, pseudovardenafil and hongdenafil in foods, simultaneously, high performance liquid chromatography(HPLC) and liquid chromatography-mass spectrometry (LC/MS) were used. The HPLC/UV analysis was performed on a column of capcellpak $C_{18}$ with 0.1% sodium-1-hexansulfonate in 0.2M ammonium formate/acetonitrile as a mobile phase. Mass spectra of the compounds by LC/MS were investigated with SCAN mode(Mass range and Fragment voltage) and SIM(Selected Ion Monitoring) mode (Ion target and Fragment voltage). The results follow as; 1. The HPLC/UV analysis was detected from 5 out of 63 samples. The content of sildenafil was in the range of 32.80 ppm ${\sim}$ 60.13 ppm from 4 out of 5 samples. The contents of sildenafil, vardenafil, homosildenafil were in the range 47.14 ppm from 1 out of 5 samples. 2. The conformed result of LC/MS was equal of detected from 5 out of 63 samples in HPLC/UV analysis. An easily available, simultaneous determination of 8 standards in adulterated health related foods was established by using a combination of LC/MS methods.
Keywords
anti-impotence drug/drug-like compounds; HPLC/UV; LC/MS; foods;
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