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http://dx.doi.org/10.4196/kjpp.2020.24.4.349

Analysis of temperature-dependent abnormal bursting patterns of neurons in Aplysia  

Hyun, Nam Gyu (Department of Physics, Jeju National University)
Hyun, Kwangho (Jeju Eastern Health Center)
Oh, Saecheol (Department of Anesthesiology and Pain Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Lee, Kyungmin (Laboratory for Behavioral Neural Circuitry and Physiology, Department of Anatomy, Brain Science and Engineering Institute, School of Medicine, Kyungpook National University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.24, no.4, 2020 , pp. 349-362 More about this Journal
Abstract
Temperature affects the firing pattern and electrical activity of neurons in animals, eliciting diverse responses depending on neuronal cell type. However, the mechanisms underlying such diverse responses are not well understood. In the present study, we performed in vitro recording of abdominal ganglia cells of Aplysia juliana, and analyzed their burst firing patterns. We identified atypical bursting patterns dependent on temperature that were totally different from classical bursting patterns observed in R15 neurons of A. juliana. We classified these abnormal bursting patterns into type 1 and type 2; type 1 abnormal single bursts are composed of two kinds of spikes with a long interspike interval (ISI) followed by short ISI regular firing, while type 2 abnormal single bursts are composed of complex multiplets. To investigate the mechanism underlying the temperature dependence of abnormal bursting, we employed simulations using a modified Plant model and determined that the temperature dependence of type 2 abnormal bursting is related to temperature-dependent scaling factors and activation or inactivation of potassium or sodium channels.
Keywords
Aplysia; Bursting; Electrical signals; Plant model; Temperature dependence;
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1 Money TG, Anstey ML, Robertson RM. Heat stress-mediated plasticity in a locust looming-sensitive visual interneuron. J Neurophysiol. 2005;93:1908-1919.   DOI
2 Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honore E. TREK-1 is a heat-activated background $K^{+}$ channel. EMBO J. 2000;19:2483-2491.   DOI
3 Finke C, Freund JA, Rosa E Jr, Braun HA, Feudel U. On the role of subthreshold currents in the Huber-Braun cold receptor model. Chaos. 2010;20:045107.   DOI
4 Rinzel J, Lee YS. Dissection of a model for neuronal parabolic bursting. J Math Biol. 1987;25:653-675.   DOI
5 Picardo MC, Weragalaarachchi KT, Akins VT, Del Negro CA. Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice. J Physiol. 2013;591:2687-2703.   DOI
6 Pace RW, Mackay DD, Feldman JL, Del Negro CA. Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice. J Physiol. 2007;582(Pt 1):113-125.   DOI
7 Paton JF, Abdala AP, Koizumi H, Smith JC, St-John WM. Respiratory rhythm generation during gasping depends on persistent sodium current. Nat Neurosci. 2006;9:311-313.   DOI
8 Rubin JE, Hayes JA, Mendenhall JL, Del Negro CA. Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations. Proc Natl Acad Sci U S A. 2009;106:2939-2944.   DOI
9 Dalton JC, Hendrix DE. Effects of temperature on membrane potentials of lobster giant axon. Am J Physiol. 1962;202:491-494.   DOI
10 Burrows M. Effects of temperature on a central synapse between identified motor neurons in the locust. J Comp Physiol A. 1989;165:687-695.   DOI
11 Hyun NG, Hyun KH, Hyun KB, Han JH, Lee K, Kaang BK. A computational model of the temperature-dependent changes in firing patterns in Aplysia neurons. Korean J Physiol Pharmacol. 2011;15:371-382.   DOI
12 Hou N, Armstrong GA, Chakraborty-Chatterjee M, Sokolowski MB, Robertson RM. $Na^{+}$-$K^{+}$-ATPase trafficking induced by heat shock pretreatment correlates with increased resistance to anoxia in locusts. J Neurophysiol. 2014;112:814-823.   DOI
13 Money TG, Rodgers CI, McGregor SM, Robertson RM. Loss of potassium homeostasis underlies hyperthermic conduction failure in control and preconditioned locusts. J Neurophysiol. 2009;102:285-293.   DOI
14 Plant RE, Kim M. Mathematical description of a bursting pacemaker neuron by a modification of the Hodgkin-Huxley equations. Biophys J. 1976;16:227-244.   DOI
15 Frankenhaeuser B, Moore LE. The effect of temperature on the sodium and potassium permeability changes in myelinated nerve fibres of Xenopus laevis. J Physiol. 1963;169:431-437.   DOI
16 Heitler WJ, Edwards DH. Effect of temperature on a voltage-sensitive electrical synapse in crayfish. J Exp Biol. 1998;201(Pt 4):503-513.   DOI
17 Hodgkin AL, Katz B. The effect of temperature on the electrical activity of the giant axon of the squid. J Physiol. 1949;109:240-249.   DOI
18 Kerkut GA, Ridge RM. The effect of temperature changes on the activity of the neurones of the snail Helix aspersa. Comp Biochem Physiol. 1962;5:283-295.   DOI
19 Hyun NG, Hyun KH, Hyun KB, Lee K. Temperature-dependent bursting pattern analysis by modified Plant model. Mol Brain. 2014;7:50.   DOI
20 Hyun NG, Hyun KH, Lee K, Kaang BK. Temperature dependence of action potential parameters in Aplysia neurons. Neurosignals. 2012;20:252-264.   DOI
21 Lim CS, Chung DY, Kaang BK. Partial anatomical and physiological characterization and dissociated cell culture of the nervous system of the marine mollusc Aplysia kurodai. Mol Cells. 1997;7:399-407.
22 Lee SH, Lim CS, Park H, Lee JA, Han JH, Kim H, Cheang YH, Lee SH, Lee YS, Ko HG, Jang DH, Kim H, Miniaci MC, Bartsch D, Kim E, Bailey CH, Kandel ER, Kaang BK. Nuclear translocation of CAMassociated protein activates transcription for long-term facilitation in Aplysia. Cell. 2007;129:801-812.   DOI
23 Plant RE. Bifurcation and resonance in a model for bursting nerve cells. J Math Biol. 1981;11:15-32.   DOI
24 Pulver SR, Griffith LC. Spike integration and cellular memory in a rhythmic network from $Na^{+}$/$K^{+}$ pump current dynamics. Nat Neurosci. 2010;13:53-59.   DOI