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http://dx.doi.org/10.4196/kjpp.2019.23.2.141

Far-infrared radiation stimulates platelet-derived growth factor mediated skeletal muscle cell migration through extracellular matrix-integrin signaling  

Lee, Donghee (Department of Physiology, Chung-Ang University College of Medicine)
Seo, Yelim (Department of Physiology, Chung-Ang University College of Medicine)
Kim, Young-Won (Department of Physiology, Chung-Ang University College of Medicine)
Kim, Seongtae (Department of Physiology, Chung-Ang University College of Medicine)
Bae, Hyemi (Department of Physiology, Chung-Ang University College of Medicine)
Choi, Jeongyoon (Department of Physiology, Chung-Ang University College of Medicine)
Lim, Inja (Department of Physiology, Chung-Ang University College of Medicine)
Bang, Hyoweon (Department of Physiology, Chung-Ang University College of Medicine)
Kim, Jung-Ha (Department of Family Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine)
Ko, Jae-Hong (Department of Physiology, Chung-Ang University College of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.23, no.2, 2019 , pp. 141-150 More about this Journal
Abstract
Despite increased evidence of bio-activity following far-infrared (FIR) radiation, susceptibility of cell signaling to FIR radiation-induced homeostasis is poorly understood. To observe the effects of FIR radiation, FIR-radiated materials-coated fabric was put on experimental rats or applied to L6 cells, and microarray analysis, quantitative real-time polymerase chain reaction, and wound healing assays were performed. Microarray analysis revealed that messenger RNA expressions of rat muscle were stimulated by FIR radiation in a dose-dependent manner in amount of 10% and 30% materials-coated. In 30% group, 1,473 differentially expressed genes were identified (fold change [FC] > 1.5), and 218 genes were significantly regulated (FC > 1.5 and p < 0.05). Microarray analysis showed that extracellular matrix (ECM)-receptor interaction, focal adhesion, and cell migration-related pathways were significantly stimulated in rat muscle. ECM and platelet-derived growth factor (PDGF)-mediated cell migration-related genes were increased. And, results showed that the relative gene expression of actin beta was increased. FIR radiation also stimulated actin subunit and actin-related genes. We observed that wound healing was certainly promoted by FIR radiation over 48 h in L6 cells. Therefore, we suggest that FIR radiation can penetrate the body and stimulate PDGF-mediated cell migration through ECM-integrin signaling in rats.
Keywords
Cell movement; Infrared rays; Integrins; Microarray analysis; Platelet-derived growth factor;
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