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http://dx.doi.org/10.4196/kjpp.2018.22.3.301

Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation  

Jin, Zhen (Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Jung, Yohan (Department of Neurology, Changwon Fatima Hospital)
Yi, Chin-ok (Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Lee, Jong Youl (Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Jeong, Eun Ae (Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Lee, Jung Eun (Department of Thoracic and Cardiovascular Surgery, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Park, Ki-Jong (Department of Neurology, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Kwon, Oh-Young (Department of Neurology, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Lim, Byeong Hoon (Department of Neurology, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Choi, Nack-Cheon (Department of Neurology, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Roh, Gu Seob (Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.22, no.3, 2018 , pp. 301-309 More about this Journal
Abstract
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cyclooxygenase-2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.
Keywords
Atorvastatin; Hippocampal cell death; Kainic acid; Lipocalin-2; Seizures;
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