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http://dx.doi.org/10.4196/kjpp.2015.19.4.309

Chronic Alcohol Consumption Results in Greater Damage to the Pancreas Than to the Liver in the Rats  

Lee, Seong-Su (Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea)
Hong, Oak-Kee (Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea)
Ju, Anes (Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany DFG Center for Nanoscale Microscopy & Molecular Physiology of the Brain (CNMPB))
Kim, Myung-Jun (Department of Physiology, College of Medicine, The Catholic University of Korea)
Kim, Bong-Jo (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health)
Kim, Sung-Rae (Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea)
Kim, Won-Ho (Division of Metabolic Disease, Center for Biomedical Sicence, National Institutes of Health)
Cho, Nam-Han (Department in Preventive Medicine, Ajou University School of Medicine)
Kang, Moo-Il (Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea)
Kang, Sung-Koo (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine)
Kim, Dai-Jin (Department of Psychiatry, College of Medicine, The Catholic University of Korea)
Yoo, Soon-Jib (Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.19, no.4, 2015 , pp. 309-318 More about this Journal
Abstract
Alcohol consumption increases the risk of type 2 diabetes. However, its effects on prediabetes or early diabetes have not been studied. We investigated endoplasmic reticulum (ER) stress in the pancreas and liver resulting from chronic alcohol consumption in the prediabetes and early stages of diabetes. We separated Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type-2 diabetic animal model, into two groups based on diabetic stage: prediabetes and early diabetes were defined as occurrence between the ages of 11 to 16 weeks and 17 to 22 weeks, respectively. The experimental group received an ethanol-containing liquid diet for 6 weeks. An intraperitoneal glucose tolerance test was conducted after 16 and 22 weeks for the prediabetic and early diabetes groups, respectively. There were no significant differences in body weight between the control and ethanol groups. Fasting and 120-min glucose levels were lower and higher, respectively, in the ethanol group than in the control group. In prediabetes rats, alcohol induced significant expression of ER stress markers in the pancreas; however, alcohol did not affect the liver. In early diabetes rats, alcohol significantly increased most ER stress-marker levels in both the pancreas and liver. These results indicate that chronic alcohol consumption increased the risk of diabetes in prediabetic and early diabetic OLETF rats; the pancreas was more susceptible to damage than was the liver in the early diabetic stages, and the adaptive and proapoptotic pathway of ER stress may play key roles in the development and progression of diabetes affected by chronic alcohol ingestion.
Keywords
Alcohol; Endoplasmic reticulum stress; OLETF rat;
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