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http://dx.doi.org/10.4196/kjpp.2015.19.3.197

Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model  

Sharma, Naveen (Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University)
Sim, Yun-Beom (Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University)
Park, Soo-Hyun (Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University)
Lim, Su-Min (Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University)
Kim, Sung-Su (Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University)
Jung, Jun-Sub (Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University)
Hong, Jae-Seung (Department of Physical Education, College of Natural Medicine, College of Medicine, Hallym University)
Suh, Hong-Won (Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.19, no.3, 2015 , pp. 197-202 More about this Journal
Abstract
Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min and returned to the cage. The blood glucose level was measured 30, 60, and 120 min after immobilization stress initiation. We found that intracerebroventricular (i.c.v.) injection with $30{\mu}g$ of glyburide, glipizide, glimepiride or tolazamide attenuated the increased blood glucose level induced by immobilization stress. Immobilization stress causes an elevation of the blood corticosterone and insulin levels. Sulfonylureas pretreated i.c.v. caused a further elevation of the blood corticosterone level when mice were forced into the stress. In addition, sulfonylureas pretreated i.c.v. alone caused an elevation of the plasma insulin level. Furthermore, immobilization stress-induced insulin level was reduced by i.c.v. pretreated sulfonylureas. Our results suggest that lowering effect of sulfonylureas administered supraspinally against immobilization stress-induced increase of the blood glucose level appears to be primarily mediated via elevation of the plasma insulin level.
Keywords
Blood glucose; Brain; Immobilization stress; Sulfonylurea;
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1 Uresin Y, Erbas B, Ozek M, Ozkok E, Gurol AO. Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress. J Renin Angiotensin Aldosterone Syst. 2004;5:93-96.   DOI
2 Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW. Repaglinide, but not nateglinide administered supraspinally and spinally exerts an anti-diabetic action in d-glucose fed and streptozotocintreated mouse models. Korean J Physiol Pharmacol. 2013;17: 493-497.   DOI
3 Ricart-Jane D, Rodriguez-Sureda V, Benavides A, Peinado-Onsurbe J, Lopez-Tejero MD, Llobera M. Immobilization stress alters intermediate metabolism and circulating lipoproteins in the rat. Metabolism. 2002;51:925-931.   DOI
4 Suh HW, Song DK, Huh SO, Kim YH. Involvement of dynorphin in immobilization stress-induced antinociception in the mouse. Eur Neuropsychopharmacol. 2000;10:407-413.
5 Surwit RS, Schneider MS, Feinglos MN. Stress and diabetes mellitus. Diabetes Care. 1992;15:1413-1422.   DOI
6 Chen Y, Kramar EA, Chen LY, Babayan AH, Andres AL, Gall CM, Lynch G, Baram TZ. Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry. 2013;18:485-496.   DOI
7 Glavin GB, Pare WP, Sandbak T, Bakke HK, Murison R. Restraint stress in biomedical research: an update. Neurosci Biobehav Rev. 1994;18:223-249.   DOI
8 Honkaniemi J. Colocalization of peptide- and tyrosine hydroxylase-like immunoreactivities with Fos-immunoreactive neurons in rat central amygdaloid nucleus after immobilization stress. Brain Res. 1992;598:107-113.   DOI
9 Honkaniemi J, Kainu T, Ceccatelli S, Rechardt L, Hokfelt T, Pelto-Huikko M. Fos and jun in rat central amygdaloid nucleus and paraventricular nucleus after stress. Neuroreport. 1992;3:849-852.   DOI
10 Seo YJ, Kwon MS, Shim EJ, Park SH, Choi OS, Suh HW. Changes in pain behavior induced by formalin, substance P, glutamate and pro-inflammatory cytokines in immobilizationinduced stress mouse model. Brain Res Bull. 2006;71:279-286.   DOI
11 Gadek-Michalska A, Tadeusz J, Rachwalska P, Spyrka J, Bugajski J. Effect of prior stress on interleukin-1${\beta}$ and HPA axis responses to acute stress. Pharmacol Rep. 2011;63:1393-1403.   DOI
12 Kalantaridou SN, Zoumakis E, Makrigiannakis A, Lavasidis LG, Vrekoussis T, Chrousos GP. Corticotropin-releasing hormone, stress and human reproduction: an update. J Reprod Immunol. 2010;85:33-39.   DOI
13 Fagerholm V, Haaparanta M, Scheinin M. ${\alpha}$2-adrenoceptor regulation of blood glucose homeostasis. Basic Clin Pharmacol Toxicol. 2011;108:365-370.   DOI
14 Groop LC. Sulfonylureas in NIDDM. Diabetes Care. 1992;15: 737-754.
15 Lebovitz HE, Feinglos MN. Sulfonylurea drugs: mechanism of antidiabetic action and therapeutic usefulness. Diabetes Care. 1978;1:189-198.   DOI
16 Groop L, Wahlin-Boll E, Groop PH, Totterman KJ, Melander A, Tolppanen EM, Fyhrqvist F. Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics. Eur J Clin Pharmacol. 1985;28:697-704.   DOI
17 Skillman TG, Feldman JM. The pharmacology of sulfonylureas. Am J Med. 1981;70:361-372.   DOI
18 Haley TJ. Pharmacological effects produced by intracerebral administration of drugs of unrelated structure to conscious mice. Arch Int Pharmacodyn Ther. 1957;110:239-244.
19 Chari M, Lam CK, Wang PY, Lam TK. Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance. Diabetes. 2008;57: 836-840.   DOI
20 Park SH, Sim YB, Kang YJ, Kim SM, Lee JK, Jung JS, Suh HW. Characterization of blood glucose level regulation in mouse opioid withdrawal models. Neurosci Lett. 2010;476: 119-122.   DOI
21 Glick D, Vonredlich D, Levine S. Fluorometric determination of corticosterone and cortisol in 0.02-0.05 milliliters of plasma or submilligram samples of adrenal tissue. Endocrinology. 1964;74:653-655.   DOI
22 Kim JG, Jung HS, Kim KJ, Min SS, Yoon BJ. Basal blood corticosterone level is correlated with susceptibility to chronic restraint stress in mice. Neurosci Lett. 2013;555:137-142.   DOI
23 Nooshinfar E, Akbarzadeh-Baghban A, Meisami E. Effects of increasing durations of immobilization stress on plasma corticosterone level, learning and memory and hippocampal BDNF gene expression in rats. Neurosci Lett. 2011;500:63-66.   DOI
24 Pitman DL, Ottenweller JE, Natelson BH. Plasma corticosterone levels during repeated presentation of two intensities of restraint stress: chronic stress and habituation. Physiol Behav. 1988;43:47-55.   DOI
25 Magarinos AM, Verdugo JM, McEwen BS. Chronic stress alters synaptic terminal structure in hippocampus. Proc Natl Acad Sci U S A. 1997;94:14002-14008.   DOI
26 Muller G, Wied S. The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro. Diabetes. 1993;42:1852-1867.   DOI
27 Amoroso S, Schmid-Antomarchi H, Fosset M, Lazdunski M. Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive $K^+$ channels. Science. 1990;247:852-854.   DOI
28 Bernardi H, De Weille JR, Epelbaum J, Mourre C, Amoroso S, Slama A, Fosset M, Lazdunski M. ATP-modulated $K^+$ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release. Proc Natl Acad Sci U S A. 1993;90:1340-1344.   DOI
29 Levin BE, Brown KL, Dunn-Meynell AA. Differential effects of diet and obesity on high and low affinity sulfonylurea binding sites in the rat brain. Brain Res. 1996;739:293-300.   DOI