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http://dx.doi.org/10.4196/kjpp.2014.18.6.457

Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization  

Park, Joo Min (Department of Physiology, Jeju National University School of Medicine)
Jung, Sung-Cherl (Department of Physiology, Jeju National University School of Medicine)
Eun, Su-Yong (Department of Physiology, Jeju National University School of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.18, no.6, 2014 , pp. 457-460 More about this Journal
Abstract
At central synapses, activity-dependent synaptic plasticity has a crucial role in information processing, storage, learning, and memory under both physiological and pathological conditions. One widely accepted model of learning mechanism and information processing in the brain is Hebbian Plasticity: long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD are respectively activity-dependent enhancement and reduction in the efficacy of the synapses, which are rapid and synapse-specific processes. A number of recent studies have a strong focal point on the critical importance of another distinct form of synaptic plasticity, non-Hebbian plasticity. Non-Hebbian plasticity dynamically adjusts synaptic strength to maintain stability. This process may be very slow and occur cell-widely. By putting them all together, this mini review defines an important conceptual difference between Hebbian and non-Hebbian plasticity.
Keywords
Hebbian Plasticity; Long-term depression; Long-term potentiation; Synapse; Synaptic Plasticity;
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Times Cited By KSCI : 6  (Citation Analysis)
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