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http://dx.doi.org/10.4196/kjpp.2014.18.3.249

KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model  

Li, Hailan (Department of Biochemistry, Chung-Ang University College of Medicine)
Kim, Jandi (Department of Biochemistry, Chung-Ang University College of Medicine)
Hahn, Hoh-Gyu (Organic Chemistry Laboratory, Korea Institute of Science & Technology)
Yun, Jun (Organic Chemistry Laboratory, Korea Institute of Science & Technology)
Jeong, Hyo-Soon (Department of Biochemistry, Chung-Ang University College of Medicine)
Yun, Hye-Young (Department of Biochemistry, Chung-Ang University College of Medicine)
Baek, Kwang Jin (Department of Biochemistry, Chung-Ang University College of Medicine)
Kwon, Nyoun Soo (Department of Biochemistry, Chung-Ang University College of Medicine)
Min, Young Sil (Department of Herb Industry, Jungwon University)
Park, Kyoung-Chan (Department of Dermatology, Seoul National University Bundang Hospital)
Kim, Dong-Seok (Department of Biochemistry, Chung-Ang University College of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.18, no.3, 2014 , pp. 249-254 More about this Journal
Abstract
The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase, the rate-limiting enzyme in melanogenesis, although tyrosinase was not inhibited directly. KHG26792 activated extracellular signal-regulated kinase (ERK), whereas an ERK pathway inhibitor, PD98059, rescued KHG26792-induced hypopigmentation. These results suggest that KHG26792 decreases melanin production via ERK activation. Moreover, the hypopigmentary effects of KHG26792 were confirmed in a pigmented skin equivalent model using Cervi cornus Colla (deer antler glue), in which the color of the pigmented artificial skin became lighter after treatment with KHG26792. In summary, our findings suggest that KHG26792 is a novel skin whitening agent.
Keywords
ERK; KHG26792; Melanogenesis; Skin equivalent; Tyrosinase;
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Times Cited By KSCI : 2  (Citation Analysis)
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