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http://dx.doi.org/10.4196/kjpp.2014.18.2.163

Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood  

Choi, Jeong Kyu (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
Moon, Ki Myung (Department of Surgery, Pusan National University Yangsan Hospital)
Jung, Seok Yun (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
Kim, Ji Yong (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
Choi, Sung Hyun (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
Kim, Da Yeon (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
Kang, Songhwa (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
Chu, Chong Woo (Department of Surgery, Pusan National University Yangsan Hospital)
Kwon, Sang Mo (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.18, no.2, 2014 , pp. 163-168 More about this Journal
Abstract
Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC-CFUs) and plasma homocysteine levels in healthy men (r=-0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men.
Keywords
Endothelial progenitor cells; EPC; Exercise; Homocysteine; Regular exercise training;
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